A thorough yet concise account of cancer biology, this book emphasizes the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It also defines the fundamental pathophysiological changes that occur in tumor tissue and in the host animal or patient. The approach throughout the book is to discuss the historical development of a field, citing the key experimental advances to the present day, and to evaluate the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well illustrated with schematic diagrams and actual research data to demonstrate points made in the text, and there is an extensive, up-to-date bibliography. In this revision, Dr. Ruddon has organized his text to provide more integrated discussion of the many topics covered in the third edition. At the same time, he has included much new material on molecular genetics and genetic diagnosis (e.g., DNA microarrays to mark tumors), RNA interference, stem cells, cell cycle regulation, angiogenesis, etc.

The press and other media constantly report news stories about dangerous chemicals in the environment, miracle cures, the safety of therapeutic treatments, and potential cancer-causing agents. But what exactly is actually meant by “increased risk”—should we worry if we are told that we are at twice the risk of developing an illness? And how do we interpret “reduced risk” to properly assess the benefits of noisily touted dietary supplements? Demonstrating the difficulty of separating the hype from the hypothesis, noted epidemiologist Michael Bracken clearly communicates how clinical epidemiology works. Using everyday terms, Bracken describes how professional scientists approach questions of disease causation and therapeutic efficacy to provide readers with the tools to help them understand whether warnings of environmental risk are truly warranted, or if claims of therapeutic benefit are justified.

The government is not a neutral arbiter of truth. It never has been. It never will be. Doubt everything. John Stossel does. A self-described skeptic, he has dismantled society’s sacred cows with unerring common sense. Now he debunks the most sacred of them all: our intuition and belief that government can solve our problems. In No, They Can’t, the New York Times bestselling author and Fox News commentator insists that we discard that idea of the “perfect” government—left or right—and retrain our brain to look only at the facts, to rethink our lives as independent individuals—and fast. With characteristic tenacity, John Stossel outlines and exposes the fallacies and facts of the most pressing issues of today’s social and political climate—and shows how our intuitions about them are, frankly, wrong: • the unreliable marriage between big business, the media, and unions • the myth of tax breaks and the ignorance of their advocates • why “central planners” never create more jobs and how government never really will • why free trade works—without government Interference • federal regulations and the trouble they create for consumers • the harm caused to the disabled by government protection of the disabled • the problems (social and economic) generated by minimum-wage laws • the destructive daydreams of “health insurance for everyone” • bad food vs. good food and the government’s intrusive, unwelcome nanny sensibilities • the dumbing down of public education and teachers’ unions • how gun control actually increases crime . . . and more myth-busting realities of why the American people must wrest our lives back from a government stranglehold. Stossel also reveals how his unyielding desire to educate the public with the truth caused an irreparable rift with ABC (nobody wanted to hear the point-by- point facts of ObamaCare), and why he left his long-running stint for a new, uncensored forum with Fox. He lays out his ideas for education innovation as well and, finally, makes it perfectly clear why government action is the least effective and desirable fantasy to hang on to. As Stossel says, “It’s not about electing the right people. It’s about narrowing responsibilities.” No, They Can’t is an irrefutable first step toward that goal.

What do we know about the possible poisons that industrial technologies leave in our air and water? How reliable is the science that federal regulators and legislators use to protect the public from dangerous products? As this disturbing book shows, ideological or economic attacks on research are part of an extensive pattern of abuse. Thomas O. McGarity and Wendy E. Wagner reveal the range of sophisticated legal and financial tactics political and corporate advocates use to discredit or suppress research on potential human health hazards. Scientists can find their research blocked, or find themselves threatened with financial ruin. Corporations, plaintiff attorneys, think tanks, even government agencies have been caught suppressing or distorting research on the safety of chemical products. With alarming stories drawn from the public record, McGarity and Wagner describe how advocates attempt to bend science or “spin” findings. They reveal an immense range of tools available to shrewd partisans determined to manipulate research. Bending Science exposes an astonishing pattern of corruption and makes a compelling case for reforms to safeguard both the integrity of science and the public health.

The only guide to understanding ethical challenges in engineering projects from both a technical and a social perspective What does it mean to be a "good" engineer, planner, or design professional in the ethical sense? Technical professionals must make daily decisions which impact upon the quality of life of those who live near the facilities, plants, structures, and thoroughfares they design, and in the cities and communities they plan and build. The questions of where these projects are built, who they are to serve, and how they will affect those who live near them are at the heart of Socially Responsible Engineering. Written from the perspective of the engineer, this new resource from two leading engineering authors is essential to professionals and students who must grapple with how solutions to engineering problems impact the people those solutions are meant to serve. The first book of its kind to focus on the environmental implications of engineering ethics and justice, Socially Responsible Engineering provides a wealth of tools for evaluating projects from an ethical perspective and properly assessing the inherent risk to communities affected by engineering projects. This thorough book provides a historical and philosophical foundation of environmental justice, as well as: Case studies highlighting real-world concepts of environmental justice Practical examples of investigations, resolutions when possible, and questions for further debate Biographical sketches of key scientists, engineers, and activists who have contributed to our growing sense of environmental justice