This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry. The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry. Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations: Extensive use of colour to highlight changes in structure and bonding during reactions Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

This new volume in a highly regarded, established series provides complete coverage of the heterocyclic chemistry of isoxazoles.

Advances in Heterocyclic Chemistry

Synthesis, Reactions, and Spectroscopy presents a comprehensive review of the literature from 1983 to the present covering oxazoles, mesoionic oxazoles, oxazolones, oxazolines, and chiral bisoxazolines. In-depth coverage includes synthesis, reactions, spectroscopic and physical properties for each class of compounds, as well as important developments related to the use of those compounds.

This new volume in a highly regarded, established series provides complete coverage of the heterocyclic chemistry of isoxazoles.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

This book serves as a supplement to The Pyrazines, Volume 41 of theChemistry of Heterocyclic Compounds series. It covers theliterature published between 1979 and 2000, and–together withVolume 41–provides a complete, up-to-date reference forheterocyclic chemists. It emphasizes practical approaches topyrazine chemistry, offers a full appendix of all simple pyrazinesup to 2000, and features detailed coverage of the following topics: Systematic descriptions of all primary synthetic routes topyrazines Other preparative routes to alkylpyrazines and theirreactions Halogenopyrazines and their synthetic uses Oxypyrazines and trivial names for pharmaceutical oragrochemical pyrazines Thiopyrazines Amino-, nitro-, and other similar pyrazines and theirreactions Pyrazinecarboxylic acids and their derivatives The supplement features extensive cross-references to theoriginal volume and uses chemical nomenclature as per current IUPACrecommendations

This volume in the Chemistry of Heterocyclic Compounds series presents a comprehensive review of the quinoxaline literature from 1975 to the present (2002), updating Volumes 5 and 35. It provides an alphabetical table of known simple quinoxalines, including new compounds discussed in this volume and their physical data, as well as the pyrazines from the original volumes. Biological activities, spectral or other physical studies, and other such materials appear at appropriate points in the text. The in-depth coverage includes synthesis, reactions, spectroscopic, and physical properties for each class of compounds. Chemistry of Heterocyclic Compounds, Volume 61: Supplement II provides the most up-to-date summation of knowledge of the synthetic chemistry of quinoxalines.

The Chemistry of Heterocyclic Compounds series attempts to make the extraordinarily complex and diverse field of heterocyclic chemistry as organized and readily accessible as possible, presenting a basic reference collection for practicing researchers. Volume 60, Oxazoles: Synthesis, Reactions, and Spectroscopy, Part A proves the sole comprehensive resource on the synthetic chemistry of oxazoles–heterocyclic compounds containing nitrogen and oxygen, specifically five-membered, unsaturated rings. Oxazoles have a wide variety of applications in synthetic organic chemistry and have been found in numerous natural products such as hennoxazole, thiangazole, calyculin, halicondrins, pyrenolide, virginiamycin, amphotericin, and phorboxazoles. This volume provides an authoritative review of the literature since 1983, highlights compounds of commerical importance, and includes in-depth coverage of the synthesis, reactions, and spectroscopic and physical properties for each class of compounds. It also discusses in detail the exciting developments on the use of chiral bioxazolines in asymmetric synthesis.