For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics. Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses. Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the material.Biopharmaceutics and Clinical Pharmacokinetics features a growth-oriented format that systematicallydevelops and interrelates all subject matter .. . introduces basic theory and fields of application... emphasizes model-independent pharmacokinetic analyses ... presents biopharmaceutical aspectsof product design and evaluation .. . offers a unique approach to teaching dosage regimen design andindividualization . .. and considers structural modification of drug molecules for problems associatedwith pharmacokinetics. As a comprehensive coverage of the basic principles and the recent achievements in the field, noother textbook does as much for students of pharmacy, pharmacology, medicinal chemistry, andmedicine, or for scientists who desire a simple but thorough introduction to theory and application.

Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. - Uses individual drugs to explain molecular actions - Full color art program explains molecular and chemical concepts graphically - Logical structure reflecting the current state of pharmacology and translational research - Covers such intricacies as drug resistance and cell death - Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.

Pharmacologists can be considered pioneers of the study of kinetics of materials introduced into biological systems. The study of drug kinetics is particularly suited to a formulation of relatively simple models which make possible an interpretation of the time-dependent nature of various important phenomena (e. g. distribution by means of diffu sion through membranesl. The objective of the NATO ASI Course on Pharmacokinetics was that of presenting and dis cussing the mathematical and statistical approaches current ly available or being developed for the description, inter pretation and prediction of the fate of drugs and tracer substances administered to living beings. Different physi cal methods for measuring drugs and tracer substances were considered, but the emphasis was on the interpretation of the results of the measurements in terms of mathematical and statistical models. The present book contains all invit ed lectures given in this Course by outstanding internation al authorities and specialists from different fields. A great effort was made to keep a balance among the mathemati cal, physical, biological and clinical aspects of the prob lems; exchange of ideas and experiences between scientists with a physico-mathematical background and scientists with a biomedical background was encouraged and all participants were deeply involved in fruitful discussions. This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.

First multi-year cumulation covers six years: 1965-70.

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existi

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.

Since the first edition of this book was published in 2005, drug therapy has seen both breakthrough advances and sobering setbacks. The changes will continue. That's why every health care professional, hospital and health system, pharmacy, and medical school needs this invaluable reference. It will help you detect, prevent and manage drug-related diseases. And also remind you to always ask yourself the increasingly critical question: "Could this disease be drug-related?"

Clinical Pharmacokinetics: The MCQ Approach is a self-teaching guide to the subject. The reader is guided through the principles of the subject as they are applied to increasingly complex situations. The volume contains a number of single and multiple-choice questions, many requiring graphing and calculation techniques and is intended as an instructional tool both for the student and practicing professional. The volume aims to test to reader's analytical skills when presented with experimental data. It will be of interest to students of pharmacy, clinical pharmacology and biopharmaceutics as well as to instructors in those subjects, both in the teaching of the subject and in the design of examination material.