Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.

Check Point NGX VPN-1/Firewall-1 is the next major release of Check Point's flagship firewall software product, which has over 750,000 registered users. The most significant changes to this release are in the areas of Route Based VPN, Directional VPN, Link Selection & Tunnel Management, Multiple Entry Points, Route Injection Mechanism, Wire Mode, and SecurePlatform Pro. Many of the new features focus on how to configure and manage Dynamic Routing rules, which are essential to keeping an enterprise network both available *and* secure. Demand for this book will be strong because Check Point is requiring all of its 3rd party developers to certify their products for this release.* Packed full with extensive coverage of features new to the product, allowing 3rd party partners to certify NGX add-on products quickly* Protect your network from both internal and external threats and learn to recognize future threats* All yuou need to securly and efficiently deploy, troubleshoot, and maintain Check Point NXG

This book is a critical exploration of Israel's curfew-closure policy in the Occupied Palestinian Territories through the eyes of CheckpointWatch, an organization of Israeli women monitoring human rights abuses. The book combines observers' daily reports from the checkpoints and along the Separation Wall, with analysis of the bureaucracy that supports the ongoing occupation. Keshet demonstrates the link between Israeli bureaucracy and the closure system as integral to a wider project of ethnic cleansing. As co-founder of the group, Keshet critically reviews the organisation's transformation from a feminist, radical protest movement to one both reclaimed by, and reclaiming, the consensus. Illustrating the nature of Israeli mainstream discourse as both anodyne and cruel, the book also analyses Israeli media representation of Checkpoint Watch and human rights activism in general. Keshet contends that the dilemmas of these Israeli women, torn between opposition to the Occupation and their loyalty to the state, reflects political divisions within Israel society as a whole.

Check Point Software Technologies is the worldwide leader in securing the Internet. The company's Secure Virtual Network (SVN) architecture provides the infrastructure that enables secure and reliable Internet communications. Check Point recently announced a ground-breaking user interface that meets the industry's next generation Internet security requirements, including simplified security management for increasingly complex environments. Built upon Check Point's Secure Virtual Network (SVN) architecture, the Next Generation User Interface revolutionizes the way security administrators define and manage enterprise security by further integrating management functions into a security dashboard and creating a visual picture of security operations. The Next Generation User Interface delivers unparalleled ease-of-use, improved security and true end-to-end security management. Check Point's revenues have more than doubled in each of the last two years, while capturing over 50% of the VPN market and over 40% of the firewall market according to IDC Research. The explosive growth of the company is further evidenced by over 29,000 IT professionals becoming Check Point Certified so far. This book will be the complimentary to Syngress' best-selling Check Point Next Generation Security Administration, which was a foundation-level guide to installing and configuring Check Point NG. This book will assume that readers have already mastered the basic functions of the product and they now want to master the more advanced security and VPN features of the product. Written by a team of Check Point Certified Instructors (the most prestigious Check Point certification) this book will provide readers with a complete reference book to Check Point NG and advanced case studies that illustrate the most difficult to implement configurations. Although not a Study Guide, this book will cover all of the objectives on Check Point's CCSE Exam. · The reader will learn to design and configure a Virtual Private Network (VPN). · The reader will learn to configure Check Point NG for High Availability (HA), which is the ability of a system to perform its function continuously (without interruption) for a significantly longer period of time than the reliabilities of its individual components would suggest. · The reader will learn to use SeucureUpdate, which allows them to perform simultaneous, secure, enterprise-wide software updates.

Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal cells, checkpoint pathways are activated when genetic or cellular homeostasis is compromised, and signals are then transduced to re-stabilize homeostasis, and, failing this, to activate the apoptotic machinery to induce a cellular suicidal response. This implies that both survival and cell death pathways are induced following checkpoint activation, and that the final decision is dependant on the net result of integrating the two sets of signals. It is intriguing that checkpoint pathways are also critical in cancer therapy to provide an apoptotic stimulus when cellular damage induced by the therapeutic agent is detected by the sensor system. Therefore, it is not surprising that failure in pro-survival checkpoint response will render tumor cells hypersensitive to cytotoxics and, conversely, failure in pro-apoptotic checkpoint response will induce genetic instability and/or therapeutic resistance. Understanding the intricacies of checkpoint response is, therefore, central to the design of therapeutic regimen that will enhance antitumor effects. Although early versions of this design entail combination of cytotoxic agents with cell cycle or checkpoint inhibitors, a greater understanding of the concepts could make such combinations clinically more effective. The contributions in this book will consolidate the current state of knowledge on checkpoint responses that may lay the foundation for hypothesis-driven rational approaches in advancing the management of cancer. The immediate attraction of the book to the scientific community is that it represents a timely opportunity to build upon existing concepts of checkpoints to expand our understanding of the inner workings of the critical checkpoint machinery. The present understanding has provided ample appreciation that response to checkpoint activation is manifested through coordinated inhibition of cyclin-dependent kinase (CDK) complexes in G1, S and/or the G2 phase in order to arrest the cell cycle. Kinase inhibition can occur through several mechanisms, including inhibitory phosphorylation of CDK, destruction of the cognate cyclins, and recruitment of CDK inhibitors from the INK and WAF1/CIP1 families. However, the wealth of information from recent discoveries needs to be examined critically to consolidate our conceptual knowledge of checkpoints. At the same time, there is acute awareness in the diversity of checkpoint response between cytotoxic agents, and this serves as a reminder of the magnitude of complexity that is inherent in checkpoint regulation. This volume is intended to bring the cancer research community closer toward an improved understanding of this regulation, how checkpoint abnormalities can impact negatively on cancer therapy, and emerging strategies to target checkpoint response as a therapeutic end-point.

Check Point NGX R65 is the next major release of Check Point's flagship firewall software product, which has over 750,000 registered users. Check Point's NGX is the underlying security software platform for all of the company's enterprise firewall, VPN and management solutions. It enables enterprises of all sizes to reduce the cost and complexity of security management and ensure that their security systems can be easily extended to adapt to new and emerging threats. This title is a continuation of Syngress' best-selling references on Check Point's market leading Firewall and VPN products. - First book to market covering Check Point's new, flagship NGX R65 Firewall/VPN - Provides bonus coverage for Check Point's upcoming NGX R65 Certification exams - Companion Web site offers customized scripts for managing log files

Here's the book you need to prepare for Check Point's VPN-1/FireWall-1 Management II NG exam, 156-310. Written by two Check Point security experts who know exactly what it takes to pass the test, this Study Guide provides: Assessment testing to focus and direct your studies In-depth coverage of official exam objectives Hundreds of challenging practice questions, in the book and on the CD Authoritative coverage of all exam objectives, including: Installing and configuring VPN-1/FireWall-1 Gateway Administering post-installation procedures Configuring user tracking Using the VPN-1 SecureClient packaging tool Configuring an HTTP, CVP, and TCP security server Setting up a logical server for load balancing of HTTP traffic Configuring and testing VPN-1 SecuRemote and VPN-1 SecureClient Setting up VPN desktop policies and use Security Configuration Verification Enabling Java blocking, URL filtering and anti-virus checking Establishing trust relationships with digital certificates Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

This book constitutes the strictly refereed post-workshop proceedings of the International Workshop on Job Scheduling Strategies for Parallel Processing, held in conjunction with IPPS '96 symposium in Honolulu, Hawaii, in April 1996. The book presents 15 thoroughly revised full papers accepted for inclusion on the basis of the reports of at least five program committee members. The volume is a highly competent contribution to advancing the state-of-the-art in the area of job scheduling for parallel supercomputers. Among the topics addressed are job scheduler, workload evolution, gang scheduling, multiprocessor scheduling, parallel processor allocation, and distributed memory environments.

This book constitutes the refereed proceedings of the 16th International Conference on Analytical and Stochastic Modeling Techniques and Applications, ASMTA 2009, held in Madrid, Spain, in June 2009 in conjunction with ECMS 2009, the 23nd European Conference on Modeling and Simulation. The 27 revised full papers presented were carefully reviewed and selected from 55 submissions. The papers are organized in topical sections on telecommunication networks; wireless & mobile networks; simulation; quueing systems & distributions; queueing & scheduling in telecommunication networks; model checking & process algebra; performance & reliability analysis of various systems.

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.