Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.

Completely revised and updated to contain the latest developments in combating cholesterol, a valuable guide shows how to lower cholesterol through menu plans, low-fat dietary regimens, and all-natural remedies; explains the new cholesterol guidelines released by the National Institute of Health; features new sections on vitamins and herbs; and much more. Original.

In recent years, researchers have accumulated a growing body of evidence linking cholesterol oxides with human diseases such as atherosclerosis and cancer. This book presents what is presently known about the biological activities of cholesterol oxides and is intended to stimulate thinking in new areas of diet-heart or diet-cancer research. Topics discussed include the oxidation of cholesterol, methods of analysis of cholesterol oxides, cholesterol oxide content in foods, effects of cholesterol oxides on cell membranes, and cytotoxicity of cholesterol oxides. The book will be an essential reference source for researchers working directly with cholesterol and cholesterol oxides, as well as researchers concerned with the wider aspects of chemistry, biology, and medicine.

Cholesterol is a soft, waxy substance found among the lipids (fats) in the bloodstream and in all the body's cells. It's an important part of a healthy body because it's used to form cell membranes, some hormones and is needed for other functions. But a high level of cholesterol in the blood -- hypercholesterolemia -- is a major risk factor for coronary heart disease, which leads to heart attack. Cholesterol and other fats can't dissolve in the blood. They have to be transported to and from the cells by special carriers called lipoproteins. There are several kinds, but the key ones are low-density lipoprotein (LDL) and high-density lipoprotein (HDL) Low-density lipoprotein is the major cholesterol carrier in the blood. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries feeding the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This field is alive with exciting new research in all areas including frontal advances in the areas of managing cholesterol as well as cholesterol lowering drugs. This new book focuses on cholesterol in atherosclerosis and coronary heart disease.

Advances in Cholesterol Research presents a range of topics which, for the most part, have not been reviewed in recent years in books published on cholesterol. The subject area can be divided into two main sections. The intracellular and extracellular dynamics of cholesterol. The intracellular dynamics of cholesterol includes the intracellular distributions of cholesterol, cellular functions of the sterol, cholesterol metabolism in steroidogenic tissues, the cholestryl ester cycle, relation between cholesterol and dolichol biosynthesis, and the role of cholesterol in tumor cell proliferation. The section on extracellular dynamics of cholesterol includes the biogenesis of high density lipoprotein subclasses, structure-function relation in lecithin: cholesterol acyltransferase, and the role of cholesterol in atherosclerosis and in membrane fusion.

Most components of the biosphere are continuously ex posed to oxygen from the atmosphere. Accordingly, the inex orable deterioration of all organic compounds by the slow attack of oxygen must occur. Despite this eventuality, a definitive treatment of oxygen-dependent decomposition of any single important natural product has not heretofore been made. The instant monograph attempts to provide a complete description of the autoxidation of one such impor tantnatural product, cholesterol, as the matter is currently understood. The autoxidation of cholesterol in Nature has been a matter of interest to others since the close of the nine teenth century and to me for the past three decades. In this monograph I present aspects of what I have learned about cholesterol autoxidation during that interval. Be cause of the diffuse ann troublesoae nature of the subject I have selected to cite references to the literature rather fully, so that all items discussed may be properly evaluated by the interested reader. Though such extensive citation of references makes for labored reading, I hope the text will serve as a definitive treatment of the subject from which other studies may be engendered without extensive recourse to the older material. An .attempt has been made to include much related in formation so that a detailed awareness of the interrelation ships between cholesterol autoxidation and other aspects of chemistry, metabolism, and toxicology may be had. I risk teaching more on the subject than any reader care to learn.

A review of the clinical trials evidence which was used to support the development of the National Cholesterol Education Program guidelines. Meant to provide evidence about the correlation between coronary heart disease (CHD) and high cholesterol levels and the need to create new guidelines for education and treatment in an effort to prevent cases of CHD. Findings of studies and clinical trials are included, along with charts and graphs which show the trends and correlations. The objectives, scope, and methodology used in each study is discussed.

In this updated version of the bestsellng cholesterol book, Roth and Streicher tell the truth about bad cholesterol and good cholesterol and how to read labels to discover hidden cholesterol levels, how to eat out, and the benefits and side effects of available medicine.