Angiogenesis and lymphangiogenesis have become attractive targets for drug therapy because of their key roles in a broad spectrum of pathological disease states ranging from macular degeneration to tumor growth and metastasis. A substantial increase in the research effort over the past decade has deepened our understanding of the basic mechanisms underlying angiogenesis and lymphangiogenesis, promoting the development of promising therapeutics for the clinical management of vascular-related diseases. These extraordinary advancements have been built upon a vast array of diverse analytical techniques developed globally throughout the field. Over the years, these methods have evolved to suit the specific needs of different researchers and experimental scenarios, resulting in a myriad of technical variants of basic assay approaches. "The Textbook of Angiogenesis and Lymphangiogenesis: Methods and Applications" is an up-to-date comprehensive textbook on angiogenesis and lymphangiogenesis techniques and applications. This volume is designed to embody the collective works of experts in the clinical as well as the basic research arenas who have significantly contributed to the development and application of techniques in all areas of angiogenesis and lymphangiogenesis. Each chapter introduces and discusses one or a group of closely related techniques and convey step-by-step protocol information and detailed technical guidance to the reader. Emphasis has been placed on explanatory illustrations, critical technical steps as well as divulging information on the benefits and caveats of specific practices related to the methods discussed. This manual is intended to serve as a written guide for both newcomers and established professionals in the field.

War and revolution, economic crises and political conflict are the very stuff of modern history. This guide to the last 100 years of great power conflict, social rebellion, strikes and protests gives us the essential history of the world in which we live. Based on the Timeline TV series this is a rapid and accessible guide for those who want to know how power is exercised, by who, and for what purposes in the modern world. From the rise and fall of great empires in two world wars, the Cold War and the ‘war on terror’ through to the rise of China Timelines describes the shifts in the imperial structure of the world. And it looks at the impact of those changes in the conflict zones of the 21st century, including Afghanistan, Iraq and Iran. Finally Timelines looks at moments of popular resistance, from the Russian and Spanish revolutions to the fall of Apartheid in the 1990s and the ongoing socialist experiment that is Hugo Chavez’s Venezuela. We live in turbulent times. These essays show us how we got here and outline the forces that are going to shape the history of the 21st century.

This book is an extensive and detailed guide to the subject of materials ageing in light-water nuclear reactors. Proper management of materials degradation is essential for the safe, reliable, and economic operation of nuclear power plants across the globe. This handbook features a stunning and thorough observational treatment of the key materials degradational phenomena in light-water reactors, capturing the results of some typical destructive examinations that have been carried out to understand and furthermore mitigate these failures. It provides a comprehensive collection of unique photographs, detailed schematics, concise analyses, as well as precise measurements and expert recommendations. It is organized in such a manner that engineers and scientists can use the observations presented to not only arrive at their own conclusions but also subsequently improve their knowledge of specific materials ageing issues. This handbook is supported by the Materials Ageing Institute (MAI) and Électricité de France (EDF) and is an extensive update to the previous edition, featuring up-to-minute information to reflect the state of the art as of 2020. Since its founding in 2008, the MAI has succeeded in expanding its membership and today represents two-thirds of the world's installed nuclear power capacity, benefiting from nearly 5,000 years of combined experience in reactor operation. The vast archive of past observational data and world-leading expert recommendations presented in this handbook leverage the unique expertise of the MAI in studying the key degradation phenomena of materials to ensure the secure and sustainable operation of carbon-free electricity production. It is a must-have on the desks of any engineers or researchers involved in ageing management for light-water reactors.

The timeline is burning. While teenage twins Malcolm and Valentine Gilbert struggle to reach their full potential, an enemy accuses them of attacking his future, and his quest for vengeance threatens the timeline. To survive, the twins must learn the truth about themselves and their mysterious accuser. Failure could mean the end of Time itself.

In their memoir, two American Mennonite women share stories of how they connected with students at a medical college in Sichuan, China, in the mid-1980s. Their host city, Luzhou, had been designated a “closed city,” which meant that foreigners could not visit it without special permission. Fran and Mary Ann were initially escorted whenever they left the campus. Even though they eventually were able to roam the city, their interactions with Chinese people were always scrutinized. Still, by hosting English conversation parties, taking taiji lessons, interacting with students in the classroom, meeting people on walks, and going on outings, the teachers made meaningful connections. Educational, cross-cultural exchanges such as the one Fran and Mary Ann participated in suggest a path forward for easing tensions between the United States and China today.

Nuclear Corrosion: Research, Progress and Challenges, part of the "Green Book series of the EFC, builds upon the foundations of the very first book published in this series in 1989 ("Number 1 - Corrosion in the Nuclear Industry). This newest volume provides an overview on state-of-the-art research in some of the most important areas of nuclear corrosion. Chapters covered include aging phenomena in light water reactors, reprocessing plants, nuclear waste disposal, and supercritical water and liquid metal systems. This book will be a vital resource for both researchers and engineers working within the nuclear field in both academic and industrial environments. - Discusses industry related aspects of materials in nuclear power generation and how these materials react with the environment - Provides comprehensive coverage of the topic as written by noted experts in the field - Includes coverage of nuclear waste corrosion

Blackhatonomics explains the basic economic truths of the underworld of hacking, and why people around the world devote tremendous resources to developing and implementing malware. The book provides an economic view of the evolving business of cybercrime, showing the methods and motivations behind organized cybercrime attacks, and the changing tendencies towards cyber-warfare. Written by an exceptional author team of Will Gragido, Daniel J Molina, John Pirc and Nick Selby, Blackhatonomics takes practical academic principles and backs them up with use cases and extensive interviews, placing you right into the mindset of the cyber criminal. - Historical perspectives of the development of malware as it evolved into a viable economic endeavour - Country specific cyber-crime analysis of the United States, China, and Russia, as well as an analysis of the impact of Globalization on cyber-crime - Presents the behind the scenes methods used to successfully execute financially motivated attacks in a globalized cybercrime economy - Provides unique insights, analysis, and useful tools for justifying corporate information security budgets - Provides multiple points of view, from pure research, to corporate, to academic, to law enforcement - Includes real world cybercrime case studies and profiles of high-profile cybercriminals

This volume offers a general overview on the handling and regulating electronic evidence in Europe, presenting a standard for the exchange process. Chapters explore the nature of electronic evidence and readers will learn of the challenges involved in upholding the necessary standards and maintaining the integrity of information. Challenges particularly occur when European Union member states collaborate and evidence is exchanged, as may be the case when solving a cybercrime. One such challenge is that the variety of possible evidences is so wide that potentially anything may become the evidence of a crime. Moreover, the introduction and the extensive use of information and communications technology (ICT) has generated new forms of crimes or new ways of perpetrating them, as well as a new type of evidence. Contributing authors examine the legal framework in place in various EU member states when dealing with electronic evidence, with prominence given to data protection and privacy issues. Readers may learn about the state of the art tools and standards utilized for treating and exchanging evidence, and existing platforms and environments run by different Law Enforcement Agencies (LEAs) at local and central level. Readers will also discover the operational point of view of LEAs when dealing with electronic evidence, and their requirements and expectations for the future. Finally, readers may consider a proposal for realizing a unique legal framework for governing in a uniform and aligned way the treatment and cross border exchange of electronic evidence in Europe. The use, collection and exchange of electronic evidence in the European Union context and the rules, practises, operational guidelines, standards and tools utilized by LEAs, judges, Public prosecutors and other relevant stakeholders are all covered in this comprehensive work. It will appeal to researchers in both law and computer science, as well as those with an interest in privacy, digital forensics, electronic evidence, legal frameworks and law enforcement.

A vivid portrait of how Americans grappled with King's death and legacy in the days, weeks, and months after his assassination On April 4, 1968, Martin Luther King Jr. was fatally shot as he stood on the balcony of the Lorraine Motel in Memphis. At the time of his murder, King was a polarizing figure -- scorned by many white Americans, worshipped by some African Americans and liberal whites, and deemed irrelevant by many black youth. In The Heavens Might Crack, historian Jason Sokol traces the diverse responses, both in America and throughout the world, to King's death. Whether celebrating or mourning, most agreed that the final flicker of hope for a multiracial America had been extinguished. A deeply moving account of a country coming to terms with an act of shocking violence, The Heavens Might Crack is essential reading for anyone seeking to understand America's fraught racial past and present.