Get to know Alpha Betty’s class in the award-winning, 26-book alphabet series ANIMAL ANTICS A TO Z! From Alexander Anteater to Zachary Zebra, it’s one adventure after another. Zip along with these zany characters as they find new friends, test their talents, and have a rip-roaring good time! Dilly loves to dance. She darts! She dips! She dives through the air! But sometimes her dizzy dancing ends in a dreadful THUD. Can Dilly find a way to dance without the disasters? This series is a perfect read-aloud choice to help kids discover the joy of letter sounds and give them the phonics building blocks they need for reading success. With delightful illustrations by Paddington Bear illustrator R.W. Alley, ANIMAL ANTICS A TO Z is an excellent resource for parents and educators alike. Activities in each book plus free activities online add to the fun. Winner: Teachers’ Choice Award for Children’s Books Winner: Teachers’ Choice Award for the Family

The highly eccentric Alfred Dillwyn Knox, known simply as 'Dilly', was one of the leading figures in the British codebreaking successes of the two world wars. During the first, he was the chief codebreaker in the Admiralty, breaking the German Navy's main flag code, before going on to crack the German Enigma ciphers during the Second World War at Bletchley Park. Here, he enjoyed the triumphant culmination of his life's work: a reconstruction of the Enigma machine used by the Abwehr, the German Secret Service. This kept the British fully aware of what the German commanders knew about Allied plans, allowing MI5 and MI6 to use captured German spies to feed false information back to the Nazi spymasters. Mavis Batey was one of 'Dilly's girls', the young female codebreakers who helped him to break the various Enigma ciphers. She was called upon to advise Kate Winslet, star of the film Enigma, on what it was like to be one of the few female codebreakers at Bletchley Park. This gripping new edition of Batey's critically acclaimed book reveals the vital part Dilly played in the deception operation that ensured the success of the D-Day landings, altering the course of the Second World War.

“Between Rose Thorn and Mrs Sneddle, school is miserable. Just know I hate Rose Thorn and she hates me—end of story. Or maybe it is the beginning?” Dilly Cooper likes to draw comics and is just trying to have a little fun while getting through school. It can be hard sometimes with her nemesis, Rose Thorn, living down the street with her equally obnoxious father and dog, Tidbits. Rose lives up to her name and is a continuous thorn in Dilly’s side, always getting her into trouble. Things go from bad to worse when her favourite teacher is replaced with horrible, math-loving Mrs Sneddle. The pressure is on, between calculating Rose Thorn and the pranks from the ‘Goon Boys’, Dilly finds it hard to keep out of trouble! Then auditions for the school production cause a stir of excitement. The show turns the promise of stardom into a hair-raising catastrophe!

Learning From Children Who Read at an Early Age is the result of a three-year research project in which the authors studied a group of children who learnt to read without being taught, from before they started school until the end of Year 2 when they were given their first National Curriculum assessments. Using this study as a framework for examining how children make progress over their time in Key Stage 1 across a range of literacy skills, the authors suggest guidelines which teachers can use to help all children progress with reading.

This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

Provides a way of accounting for the relationship between language and a variety of social phenomena.

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs