This book presents the continual reassessment method (CRM) as a tool for dose-finding studies. With a focus on the implementation and practice of the CRM and its variations, it explains how the CRM may be calibrated and extended to suit common clinical settings. The book includes examples of real clinical trials data to illustrate the calibration techniques and shows how R can be used to carry out the techniques. It reviews the literature, related methodology, and theoretical properties of the CRM. It also explores alternatives for situations where the CRM fails.

In "The Glass Garden," Lily embarks on a journey to find her true purpose in life after a chance encounter with a mysterious garden and its inhabitants. As she navigates the challenges of self-discovery and overcoming her fears, Lily finds solace in yoga and discovers her passion for helping others. This heartfelt and uplifting story is a reminder that even in the darkest of times, there is always hope and the possibility of finding one's true purpose. Join Lily as she finds her way through the ups and downs of life and learns that sometimes, the most beautiful things can be found in unexpected places.

New York Times bestselling author and Life Designs, Inc. creator Martha Beck shares her step-by-step program that will guide you to fulfill your own potential and create a joyful life. In this book, you'll start by learning how to read the internal compasses already built into your brain and body--and why you may have spent your life ignoring their signals. As you become reacquainted with your own deepest desires, you'll identify and repair any unconscious beliefs or unhealed emotional wounds that may be blocking your progress. This will change your life, but don't worry--although every life is unique, major transformations have common elements, and Beck provides a map that will guide you through your own life changes. You'll learn how to navigate every stage, from the first flickering appearance of a new dream to the planning and implementation of your own ideal life. Based on Dr. Beck's work as a Harvard-trained sociologist, research associate at Harvard Business School, instructor at Thunderbird Business School, and especially on her experiences with her clients over the last six years, Finding Your Own North Star offers thoroughly tested case studies, questionnaires, and exercises to help you articulate your core desires and act on them to build a more satisfying life. “Explorers depend on the North Star when there are no other landmarks in sight. The same relationship exists between you and your right life, the ultimate realization of your potential for happiness. I believe that a knowledge of that perfect life sits inside you just as the North Star sits in its unaltering spot.” -- Martha Beck

Finding Australian Birds is a guide to the special birds found across Australia's vastly varied landscapes. From the eastern rainforests to central deserts, Australia is home to some 900 species of birds. This book covers over 400 Australian bird watching sites conveniently grouped into the best birding areas, from one end of the country to the other. This includes areas such as Kakadu in the Top End and rocky gorges in the central deserts of the Northern Territory, the Great Barrier Reef in Queensland, rainforests distributed along the eastern Australian seaboard, some of the world's tallest forests in Tasmania, the Flinders Ranges and deserts along the iconic Strzelecki and Birdsville Tracks in South Australia, and the mallee temperate woodlands and spectacular coastlines in both Victoria and south west Western Australia. Each chapter begins with a brief description of the location, followed by a section on where to find the birds, which describes specific birdwatching sites within the location's boundaries, and information on accommodation and facilities. The book also provides a comprehensive 'Bird Finding Guide', listing all of Australia's birds with details on their abundance and where exactly to see them. Of value to both Australian birdwatchers and international visitors, this book will assist novices, birders of intermediate skill and keen 'twitchers' to find any Australian species.

If you're in a fix in your career, trying to decide what to do or JUST disgruntled with your current job, this is the book for you. Starting with the premise that you can't achieve happiness in anything if you don't know what you want in life, the book uses an engaging approach to take you on a journey of self-discovery.