New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.

Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms.

In third edition of this clear, reader-friendly guide, the author addresses the challenge of calculations in genetic counseling and demonstrates how risk can be estimated for inherited disorders using a basic knowledge of the laws of probability and their application to clinical problems. The text employs a wealth of clearly explained examples and "key points" in order to guide the reader to an accurate assessment of the risk of genetic disease.

An edited volume that looks at the state of psychiatric genetics and how to chart a path forward. In this edited collection, experts from psychiatric and statistical genetics, neurobiology, and clinical psychiatry investigate whether and how to pursue the discovery of additional genetic risk factors for mental illnesses. Using the existing knowledge and frameworks of genetic risk factors, they look at how a better understanding of the biology that underlies mental illnesses can improve and enhance the care that patients receive.

How Genes Influence Behavior 2e takes a personal and lively approach to the study of behavioral genetics, providing an up-to-date and accessible introduction to a variety of approaches and their application to a wide range of disorders, and modeling a critical approach to both methods and results. This second edition includes additional biology content to help students understand the biological foundations of the field, while maintaining an appropriate focus on the main issues of relevance to psychology students; updates coverage of genomic technologies and their applications; and covers a wider range of disorders, including autism spectrum disorder, eating disorders, and intellectual disability. A new final chapter guides students through a range of quantitative approaches using worked examples that relate directly to cases and examples used earlier in the text, and addresses current issues arising from debates around reproducibility. The online resources that accompany this book include: For students *Multiple choice questions for students to check their threshold knowledge *Data sets for students to manipulate, so that they can apply what they have learned For lecturers *Figures and tables from the book, ready to download

In this volume, the psychiatrist Robert Klitzman explores how individuals confront the complex issues associated with genetic testing in their daily lives.

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Rheumatoid arthritis (RA) is a chronic autoimmune disease with poorly understood etiology. Over the years, many genetic risk factors and some environmental risk factors were discovered to be important for RA. Genetic variants from the HLA-DRB1 locus, the shared epitope alleles, in different populations show a relatively strong and consistent effect on risk of RA. Non-HLA genetic risk factors have only a moderate effect. Gene–gene and gene–environment interactions were suspected to be important with regard to the risk of RA. Indeed, some combinations were demonstrated to be extremely influential. An important feature of RA is the development of autoantibodies, e.g., RF and ACPA, that serve as biomarkers and are used in diagnosing the disease. Interestingly, most of the genetic predisposition for RA observed so far concerns risk of developing the autoantibody positive subset of the disease, that is, the form where antibodies are present. In this chapter, we will review the current knowledge on genetics in RA and introduce multiple examples of interaction.

Originally published by Oxford in 1998, Psycho-Oncology was the first comprehensive text in the field and remains the gold standard today. Edited by a team of leading experts in psycho-oncology, spearheaded by Dr. Jimmie C. Holland, the founder of the field, the text reflects the interdisciplinary nature and global reach of this growing field. Thoroughly updated and developed in collaboration with the American Psychosocial Society and the International Psycho-oncology Society, the third edition is a current, comprehensive reference for psychiatrists, psychologists, oncologists, hospice workers, and social workers seeking to understand and manage the psychological issues involved in the care of persons with cancer and the psychological, social, and behavioral factors that contribute to cancer risk and survival. New to this edition are chapters on gender-based and geriatric issues and expanded coverage of underserved populations, community based programs, and caregiver training and education.

Given the rapid increase in the worldwide incidence of gestational diabetes, the need for defining the risks and effects associated with raised glucose concentrations in pregnancy is great. Recent large studies are helping to define the risks, as well as identify the benefits of reducing glucose intolerance. Written by an esteemed list of international authors, Gestational Diabetes: Origins, Complications, and Treatment presents timely reviews relating to some of the most important aspects of gestational diabetes, specifically its causes, consequences, and treatments. Divided into five sections, the book begins with a section on metabolism in pregnancy and gestational diabetes, dealing with maternal and foetal glucose metabolism and the controversial area of what actually constitutes gestational diabetes. The next section examines risk factors and causes of gestational diabetes, including the obvious but often overlooked factors—being female and pregnant. The text also outlines environmental and genetic risk factors. The third section deals with the potential complications of gestational diabetes for both mother and offspring, considering short-term and long-term effects. The largest section in the book addresses treatments in an effort to improve the outcome for the mother and the baby. Chapters describe the nutritional approach, considered the cornerstone of treating gestational diabetes, as well as evidence for the role of exercise in its treatment and a useful strategy for treating gestational diabetes pharmacologically. The final section discusses future prospects in screening, diagnosis, prevention, pathophysiology, and treatment of gestational diabetes.