This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

A wide-ranging review of the effects of heterogeneity on individuals, populations, communities and biodiversity.

Contemporary philosophical research interconnects classical domains of philosophy, the arts, literature and social sciences. This collection of essays explores the operational role of experimentation, dissidence and heterogeneity in this process. It offers fundaments for the criticism of monolithical tendencies often put forward under the banner of the ‘Speculative Turn’ or New Realism, by means of exploring the contribution and influence of authors such as J. G. Hamann, Kierkegaard, Nietzsche and Guy Debord. These philosophers, historically placed within the margins of the philosophical mainstream, were decisive in the emergence of the philosophical thought and practices of Deleuze, Wittgenstein and Bataille, as shown here. The reader will also find re-evaluations of the contributions of Vico, Spinoza or Kant to posterity, next to new readings of authors like Foucault, Hadot, Benjamin and Adorno with regards to their significant experimental and dissident positions.

This book situates ethnic heterogeneity in the larger discussion of the welfare state and its redistributive outcomes, poverty and inequality. By using comprehensive, longitudinal data covering 1980 to 2010 from 17 high income countries, this analysis helps achieve a major milestone in comparative welfare state research both conceptually and methodologically. Conceptually, it elevates the relevance of growing ethnic heterogeneity in thinking about how politics and economics of the welfare state operate, collectively impacting the magnitudes of poverty and inequality. Methodologically, the analysis conducted in this book provides broader empirical tests for the many propositions and discourses found in the literature based largely on anecdotal evidence, case studies, and unjustifiably limited quantitative data. The innovative oeprationalization of the multidimensional character of both welfare state policies and ethnic heterogeneity help broaden the analytical frameworks of comparative welfare state research. The outcome is a major advance in the way we understand the causes and redistributive consequences of the welfare state, in which ethno-racial, religious, and especially immigration heterogeneity can play a crucial role. A thorough and insightful analysis presented in this book helps students, researchers, and policymakers better understand the ethnic heterogeneity connections of the welfare state and redistribution, together with a comparative perspective of the changing faces of ethnic heterogeneity, welfare state policies, and poverty and inequality in high income countries.

This book provides a comprehensive overview of the parameters and factors that cause heterogeneity in carbonate reservoirs, and examines how they interact with one another. It explores the various scales of heterogeneity, how they are caused, and how they can be minimized, as well as how the scales affect each other, providing practical examples in each chapter. The book concludes by discussing the effect of heterogeneity on petrophysical evaluations. As reducing heterogeneity is the only way to obtain accurate carbonate reservoir characteristics at the regional scale, the book offers an important reference guide for all geologists, engineers, and modelers working with subsurface data.

Breast cancer is a highly heterogeneous disease. Despite advances in early detection and treatment, breast cancer (BC) is the leading cause of cancer death in women worldwide. Heterogeneity negatively affects a patient’s prognosis, treatment sensitivity, and clinical outcome. In particular, the development of drug resistance mechanisms and the failure of anticancer drugs (initially or subsequently) could lie in the heterogeneity among BC patients and tumors. The major international guidelines have adopted an immunophenotypic sub-classification of BC to maximize patient eligibility for personalized therapy but do not take into account the extreme diversity existing between breast tumors (intratumor heterogeneity).

The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance. To shed some light on the debate, the Fondation Ipsen organized an international symposium which took place on April 6, 1992. This volume contains the proceedings of this meeting, which was attended by researchers in epidemiology, clinical neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.