The interrelationship between wild animal, domestic animals and human health is appreciated now more than ever before. This is because of the recognition of the involvement of wild animals in diseases of humans and domestic animals, the impact of disease on wildlife management and conservation biology, recognition of new forms of environmental contamination, and academic interest in disease as an ecological factor. This is the first introductory level book about disease in wild animals that deals with basic subjects such as the nature of disease, what causes disease, how disease is described and measured, how diseases spread and persist and the effects of disease on individual animals and populations. In contrast to authors of many other veterinary books, Gary A. Wobeser takes a more general approach to health in wild animals, recognizing that disease is one ecological factor among many and that disease can never be considered satisfactorily in isolation. Rather than focus on individual causative agents and their effect on the individual animal, the emphasis is on why disease occurred, and on the complex interactions that occur among disease agents, the environment and host populations. Written by a leading researcher in wildlife diseases, this book will fill a knowledge gap for those called to work with disease in wild animals who lack experience or training in the general features of disease as they relate to wild animals. Veterinarians, ecologists, wildlife biologists, population biologists and public health workers will find this book invaluable.

The crucial role of animal models in biomedical research calls for philosophical investigation of how and whether knowledge about human diseases can be gained by studying other species. This Element delves into the selection and construction of animal models to serve as preclinical substitutes for human patients. It explores the multifaceted roles animal models fulfil in translational research and how the boundaries between humans and animals are negotiated in this process. The book also covers persistent translational challenges that have sparked debates across scientific, philosophical, and public arenas regarding the limitations and future of animal models. Among the are persistent tensions between standardization and variation in medicine, as well as between strategies aiming to reduce and recapitulate biological complexity. Finally, the book examines the prospects of replacing animal models with animal-free methods. The Element demonstrates why animal modeling should be of interest to philosophers, social scientists, and scientists alike.

"This title explores the origins, impacts and responses to diseases that are particularly damaging, persistent and/or are currently threatening wildlife conservation"--

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity or disagreement, and suggests considerations that are relevant for resolution of these issues. Recommendations are offered for participation by investigators in ethical discussion of their work, and of biomedical animal research generally. The general themes of the chapter are that investigators play the primary role in assuring the ethical conduct of biomedical animal research, and that a crucial foundation of ethical animal research is sound science.

In recent years, zoonoses and communicable diseases common to man and animals have gained increasing attention worldwide. Human diseases that have their origins in infected animals, such as AIDS or Creutzfeldt-Jakob, have highlighted the need for a better understanding of animal diseases in terms of their epidemiology, mechanism of transmission to man, diagnosis, prevention and control. Encroachment into formerly little known ecological areas has increased exposure to such diseases. Also, the speed of modern travel facilitates the spread of the diseases once confined to specific geographic areas. Animal migration and trade pose a similar threat. This new edition provides a detailed overview of the most important zoonotic diseases including: its first appearance, most important outbreaks, latest scientific knowledge, and causative agents. It includes etiology, geographic distribution, symptoms and occurrence in man and animals, source of infection, mode of transmission, role of animals in the epidemiology of the disease, diagnostic techniques and prevention and control measures; name and number according to the International Statistical Classification of Diseases and Related Health Problems (ICD -10.). It also includes an index covering synonyms and etiologic agents' names.

This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models.The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.

Myocardial disease is one of the largest medical burdens facing populations of the developed world. Increasing diabetes and obesity in both the developed and developing world suggests that this problem will increase with time. So far, development of novel therapeutic approaches to myocardial disease has lagged behind medical need. One of the key components lacking from this area of medicine is reliable animal systems to model increasingly complex patient populations. This chapter takes a disease-centred approach to reviewing commonly used animal models of myocardial disease. It goes on to discuss possible future approaches to adapting existing models to the changing spectrum of cardiac disease.