Wiley Series in Probability and Statistics A modern perspective on mixed models The availability of powerful computing methods in recent decades has thrust linear and nonlinear mixed models into the mainstream of statistical application. This volume offers a modern perspective on generalized, linear, and mixed models, presenting a unified and accessible treatment of the newest statistical methods for analyzing correlated, nonnormally distributed data. As a follow-up to Searle's classic, Linear Models, and Variance Components by Searle, Casella, and McCulloch, this new work progresses from the basic one-way classification to generalized linear mixed models. A variety of statistical methods are explained and illustrated, with an emphasis on maximum likelihood and restricted maximum likelihood. An invaluable resource for applied statisticians and industrial practitioners, as well as students interested in the latest results, Generalized, Linear, and Mixed Models features: * A review of the basics of linear models and linear mixed models * Descriptions of models for nonnormal data, including generalized linear and nonlinear models * Analysis and illustration of techniques for a variety of real data sets * Information on the accommodation of longitudinal data using these models * Coverage of the prediction of realized values of random effects * A discussion of the impact of computing issues on mixed models

An accessible and self-contained introduction to statistical models-now in a modernized new edition Generalized, Linear, and Mixed Models, Second Edition provides an up-to-date treatment of the essential techniques for developing and applying a wide variety of statistical models. The book presents thorough and unified coverage of the theory behind generalized, linear, and mixed models and highlights their similarities and differences in various construction, application, and computational aspects. A clear introduction to the basic ideas of fixed effects models, random effects models, and mixed models is maintained throughout, and each chapter illustrates how these models are applicable in a wide array of contexts. In addition, a discussion of general methods for the analysis of such models is presented with an emphasis on the method of maximum likelihood for the estimation of parameters. The authors also provide comprehensive coverage of the latest statistical models for correlated, non-normally distributed data. Thoroughly updated to reflect the latest developments in the field, the Second Edition features: A new chapter that covers omitted covariates, incorrect random effects distribution, correlation of covariates and random effects, and robust variance estimation A new chapter that treats shared random effects models, latent class models, and properties of models A revised chapter on longitudinal data, which now includes a discussion of generalized linear models, modern advances in longitudinal data analysis, and the use between and within covariate decompositions Expanded coverage of marginal versus conditional models Numerous new and updated examples With its accessible style and wealth of illustrative exercises, Generalized, Linear, and Mixed Models, Second Edition is an ideal book for courses on generalized linear and mixed models at the upper-undergraduate and beginning-graduate levels. It also serves as a valuable reference for applied statisticians, industrial practitioners, and researchers.

This book provides a comprehensive treatment of linear mixed models for continuous longitudinal data. Next to model formulation, this edition puts major emphasis on exploratory data analysis for all aspects of the model, such as the marginal model, subject-specific profiles, and residual covariance structure. Further, model diagnostics and missing data receive extensive treatment. Sensitivity analysis for incomplete data is given a prominent place. Most analyses were done with the MIXED procedure of the SAS software package, but the data analyses are presented in a software-independent fashion.

This book covers two major classes of mixed effects models, linear mixed models and generalized linear mixed models. It presents an up-to-date account of theory and methods in analysis of these models as well as their applications in various fields. The book offers a systematic approach to inference about non-Gaussian linear mixed models. Furthermore, it includes recently developed methods, such as mixed model diagnostics, mixed model selection, and jackknife method in the context of mixed models. The book is aimed at students, researchers and other practitioners who are interested in using mixed models for statistical data analysis.

Generalized Linear Mixed Models: Modern Concepts, Methods, and Applications (2nd edition) presents an updated introduction to linear modeling using the generalized linear mixed model (GLMM) as the overarching conceptual framework. For students new to statistical modeling, this book helps them see the big picture – linear modeling as broadly understood and its intimate connection with statistical design and mathematical statistics. For readers experienced in statistical practice, but new to GLMMs, the book provides a comprehensive introduction to GLMM methodology and its underlying theory. Unlike textbooks that focus on classical linear models or generalized linear models or mixed models, this book covers all of the above as members of a unified GLMM family of linear models. In addition to essential theory and methodology, this book features a rich collection of examples using SAS® software to illustrate GLMM practice. This second edition is updated to reflect lessons learned and experience gained regarding best practices and modeling choices faced by GLMM practitioners. New to this edition are two chapters focusing on Bayesian methods for GLMMs. Key Features: • Most statistical modeling books cover classical linear models or advanced generalized and mixed models; this book covers all members of the GLMM family – classical and advanced models. • Incorporates lessons learned from experience and on-going research to provide up-to-date examples of best practices. • Illustrates connections between statistical design and modeling: guidelines for translating study design into appropriate model and in-depth illustrations of how to implement these guidelines; use of GLMM methods to improve planning and design. • Discusses the difference between marginal and conditional models, differences in the inference space they are intended to address and when each type of model is appropriate. • In addition to likelihood-based frequentist estimation and inference, provides a brief introduction to Bayesian methods for GLMMs. Walt Stroup is an Emeritus Professor of Statistics. He served on the University of Nebraska statistics faculty for over 40 years, specializing in statistical modeling and statistical design. He is a Fellow of the American Statistical Association, winner of the University of Nebraska Outstanding Teaching and Innovative Curriculum Award and author or co-author of three books on mixed models and their extensions. Marina Ptukhina (Pa-too-he-nuh), PhD, is an Associate Professor of Statistics at Whitman College. She is interested in statistical modeling, design and analysis of research studies and their applications. Her research includes applications of statistics to economics, biostatistics and statistical education. Ptukhina earned a PhD in Statistics from the University of Nebraska-Lincoln, a Master of Science degree in Mathematics from Texas Tech University and a Specialist degree in Management from The National Technical University "Kharkiv Polytechnic Institute." Julie Garai, PhD, is a Data Scientist at Loop. She earned her PhD in Statistics from the University of Nebraska-Lincoln and a bachelor’s degree in Mathematics and Spanish from Doane College. Dr Garai actively collaborates with statisticians, psychologists, ecologists, forest scientists, software engineers, and business leaders in academia and industry. In her spare time, she enjoys leisurely walks with her dogs, dance parties with her children, and playing the trombone.

Multivariate Generalized Linear Mixed Models Using R presents robust and methodologically sound models for analyzing large and complex data sets, enabling readers to answer increasingly complex research questions. The book applies the principles of modeling to longitudinal data from panel and related studies via the Sabre software package in R.A Un

Highly recommended by JASA, Technometrics, and other journals, the first edition of this bestseller showed how to easily perform complex linear mixed model (LMM) analyses via a variety of software programs. Linear Mixed Models: A Practical Guide Using Statistical Software, Second Edition continues to lead readers step by step through the process of

A fully updated edition of this key text on mixed models, focusing on applications in medical research The application of mixed models is an increasingly popular way of analysing medical data, particularly in the pharmaceutical industry. A mixed model allows the incorporation of both fixed and random variables within a statistical analysis, enabling efficient inferences and more information to be gained from the data. There have been many recent advances in mixed modelling, particularly regarding the software and applications. This third edition of Brown and Prescott’s groundbreaking text provides an update on the latest developments, and includes guidance on the use of current SAS techniques across a wide range of applications. Presents an overview of the theory and applications of mixed models in medical research, including the latest developments and new sections on incomplete block designs and the analysis of bilateral data. Easily accessible to practitioners in any area where mixed models are used, including medical statisticians and economists. Includes numerous examples using real data from medical and health research, and epidemiology, illustrated with SAS code and output. Features the new version of SAS, including new graphics for model diagnostics and the procedure PROC MCMC. Supported by a website featuring computer code, data sets, and further material. This third edition will appeal to applied statisticians working in medical research and the pharmaceutical industry, as well as teachers and students of statistics courses in mixed models. The book will also be of great value to a broad range of scientists, particularly those working in the medical and pharmaceutical areas.

Publisher Description

A bestseller for nearly 25 years, Analysis of Messy Data, Volume 1: Designed Experiments helps applied statisticians and researchers analyze the kinds of data sets encountered in the real world. Written by two long-time researchers and professors, this second edition has been fully updated to reflect the many developments that have occurred since t