Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.

China's basic work units, collectively known as the danwei system, have undergone significant reform, particularly since 1984. The author examines how this system operates and how reform is generating change in the party at grassroots level. The author demonstrates how China's post-Mao reforms have produced a quiet revolution from below as the process of political and economic liberalization has accelerated. This book presents new research findings that will be invaluable to those wishing to understand the nature of change in China.

Medical residents in hospitals are often required to be on duty for long hours. In 2003 the organization overseeing graduate medical education adopted common program requirements to restrict resident workweeks, including limits to an average of 80 hours over 4 weeks and the longest consecutive period of work to 30 hours in order to protect patients and residents from unsafe conditions resulting from excessive fatigue. Resident Duty Hours provides a timely examination of how those requirements were implemented and their impact on safety, education, and the training institutions. An in-depth review of the evidence on sleep and human performance indicated a need to increase opportunities for sleep during residency training to prevent acute and chronic sleep deprivation and minimize the risk of fatigue-related errors. In addition to recommending opportunities for on-duty sleep during long duty periods and breaks for sleep of appropriate lengths between work periods, the committee also recommends enhancements of supervision, appropriate workload, and changes in the work environment to improve conditions for safety and learning. All residents, medical educators, those involved with academic training institutions, specialty societies, professional groups, and consumer/patient safety organizations will find this book useful to advocate for an improved culture of safety.

This book contains the collection of articles from the International Conference on “Building Competitiveness through Technology Enabled Business, Management and Leadership” held on February 9 & 10, 2024. This Distinguished Event was Meticulously Organized by The American School of Business Administration, The American College, Madurai, Tamil Nadu, India.

This book provides a comprehensive overview of the latest trends and developments in AI and business innovation research. In today's rapidly changing business environment, artificial intelligence (AI) has become an essential tool for innovation and growth. From marketing and customer service to supply chain management and product development, AI is transforming the way businesses operate, allowing them to make better decisions and achieve their goals faster and more efficiently than ever before. However, the integration of AI into business operations is not without its challenges and risks. There are concerns about data privacy, cybersecurity, and the potential for AI to disrupt traditional industries and displace workers. As a result, it is essential for business leaders and researchers to understand both the potential and risks of AI, and how it can be effectively leveraged for business innovation. This book explores the potential benefits of AI for modern enterprises, including how it can be used to enhance customer service, optimize supply chain management, and improve decision-making in a range of business contexts. It also examines the role of AI in product development, marketing, and sales, and how it can be used to drive innovation and growth. The book also examines the risks and challenges associated with the integration of AI into business operations. It explores the ethical and legal implications of AI, including issues related to data privacy and security, bias in algorithms, and the impact of AI on employment and the labor market. It also examines the role of government and policymakers in regulating AI and managing the risks associated with its integration into business operations. Overall, this book provides a comprehensive and balanced perspective on the potential and risks of AI for modern enterprises.