This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

"GRASPED Pathways to Excellence" is envisioned as a comprehensive guide aimed at individuals seeking transformation in both personal and professional spheres. It likely presents 20 innovative strategies designed to navigate through the complexities of achieving excellence, covering a broad spectrum from enhancing leadership skills, adopting new technologies for growth, to fostering personal well-being and creativity. This guide's USP may lie in its dual focus on personal and professional development, offering a holistic approach rarely found in traditional business or self-help books. It emphasizes the interconnectedness of personal well-being and professional success, providing readers with a unique toolkit designed for the modern landscape of work and life. An introduction to "GRASPED Pathways to Excellence" might set the stage for a transformative journey, highlighting the book's commitment to fostering growth, innovation, and balance. It could invite readers to explore new dimensions of success, promising not just strategies but a new perspective on excellence.

The United States has publicly funded its human spaceflight program on a continuous basis for more than a half-century, through three wars and a half-dozen recessions, from the early Mercury and Gemini suborbital and Earth orbital missions, to the lunar landings, and thence to the first reusable winged crewed spaceplane that the United States operated for three decades. Today the United States is the major partner in a massive orbital facility - the International Space Station - that is becoming the focal point for the first tentative steps in commercial cargo and crewed orbital space flights. And yet, the long-term future of human spaceflight beyond this project is unclear. Pronouncements by multiple presidents of bold new ventures by Americans to the Moon, to Mars, and to an asteroid in its native orbit, have not been matched by the same commitment that accompanied President Kennedy\'s now fabled 1961 speech-namely, the substantial increase in NASA funding needed to make it happen. Are we still committed to advancing human spaceflight? What should a long-term goal be, and what does the United States need to do to achieve it? Pathways to Exploration explores the case for advancing this endeavor, drawing on the history of rationales for human spaceflight, examining the attitudes of stakeholders and the public, and carefully assessing the technical and fiscal realities. This report recommends maintaining the long-term focus on Mars as the horizon goal for human space exploration. With this goal in mind, the report considers funding levels necessary to maintain a robust tempo of execution, current research and exploration projects and the time/resources needed to continue them, and international cooperation that could contribute to the achievement of spaceflight to Mars. According to Pathways to Exploration, a successful U.S. program would require sustained national commitment and a budget that increases by more than the rate of inflation. In reviving a U.S. human exploration program capable of answering the enduring questions about humanity's destiny beyond our tiny blue planet, the nation will need to grapple with the attitudinal and fiscal realities of the nation today while staying true to a small but crucial set of fundamental principles for the conduct of exploration of the endless frontier. The recommendations of Pathways to Exploration provide a clear map toward a human spaceflight program that inspires students and citizens by furthering human exploration and discovery, while taking into account the long-term commitment necessary to achieve this goal.

Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field.

Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches represents the major source of inter-study variation. This led to early attempts towards harmonizing data analysis protocols focusing on microarray-based models for predicting toxicological and clinical end-points and on different methods for GWAS data (MAQC-II). Simultaneously, further technological developments, geared by increasing insights into the complexity of cellular regulation, enabled analyzing molecular perturbations across multiple genomics scales (epigenomics and microRNAs, metabolomics). While these were initially still based on microarray technology, this is currently being phased out and replaced by a variety of next generation sequencing-based methods enabling exploration of genomic responses to toxicants at even greater depth (SEQC-I). This raises the demand for reliable and robust data analysis approaches, ranging from harmonized bioinformatics concepts for preprocessing raw data to non-supervised and supervised methods for capturing and integrating the dynamic perturbations of cell function across dose and time, and thus retrieving mechanistic insights across multiple regulation scales. Traditional toxicology focused on dose-dependently determining apical endpoints of toxicity. With the advent of toxicogenomics, efforts towards better understanding underlying molecular mechanisms has led to the development of the concept of Adverse Outcome Pathways, which are basically presented as a structural network of linearly related gene-gene interactions regulating key events for inducing apical toxic endpoints of interest. Impulse challenges from exposure of biological systems to toxic agents will however induce a cascade-type of events, presenting both adverse and adaptive processes, thus requiring bioinformatics approaches and methods for complex dynamic data, generated not only across dose, but clearly also across time. Currently, time-resolved toxicogenomics data sets are increasingly being assembled in the course of large-scaled research projects, for instance devoted towards developing toxicogenomics-based predictive assays for evaluating chemical safety which are no longer animal-based.

Creative Dance for All Ages, Second Edition, has had a long history of providing a dance curriculum to teachers and students preparing to teach creative dance. Author Anne Gilbert demystifies expectations when teaching creative dance and provides the theory, methods, and lesson ideas for success in a variety of settings and with students of all ages. This one-stop resource offers dance teachers everything they need, including a sequential curriculum, lesson plans, instructional strategies, assessment, and other forms. It’s like having a seasoned dance teacher at your side offering inspiration and guidance all year long. Internationally recognized master teacher and author Anne Gilbert Green presents creative dance for everyone and tips on meeting the challenges of teaching it. She offers a complete package for teaching creative dance that includes the theory, methodology, and lesson plans for various age groups that can be used in a variety of settings. Gilbert also offers an entire dance curriculum for sequential teaching and learning. The second edition of her classic text has been revised, reorganized, and updated to meet all the needs of dance teachers. The second edition of Creative Dance for All Ages includes these new features: • An easy-to-navigate format helps you quickly access the material and find lesson planning and assessment tools. • Content reflects changes in the field of dance education to put you on the cutting edge. • Forty age-appropriate and brain-compatible lesson plans are accessible through the web resource, which save prep time and help ensure compliance with the latest standards. • Five downloadable video clips demonstrate the lesson plans and teaching strategies and how to put them to work in the classroom. • Suggestions for modifying lessons help you include students of all abilities. • Eight assessment forms and curriculum planning templates are adaptable to your needs. If you’re a novice teacher, the book also contains these features to ensure effective instruction: • The same conceptual approach to teaching dance was used in the first edition. • A sequential dance curriculum helps you systematically cover a 10-week quarter or 16-week semester. • Class management tips put you in control from the first day. Creative Dance for All Ages, Second Edition, is an unparalleled resource for dance educators who are looking for a conceptual creative dance curriculum that will support teaching to learners of all ages. Whether in a studio, company, recreational, or educational setting, you will discover a comprehensive and well-rounded approach to teaching dance, emphasizing the how as much as the why.

A stroke occurs when the blood supply to the part of the brain is suddenly interrupted (ischemic) or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding the brain cells (haemorrhagic). Generally, there are three treatment stages for stroke: prevention, therapy immediately after stroke, and post-stroke rehabilitation. Therapies to prevent stroke are based on treating an individual's underlying risk factors. This book includes within its scope the prevention, risk factors, symptoms, diagnosis, treatment, and rehabilitation of stroke. Leading-edge scientific research from throughout the world is presented.

This Working Group III contribution to the IPCC Sixth Assessment Report provides a comprehensive and transparent assessment of the literature on climate change mitigation. The report assesses progress in climate change mitigation options for reducing emissions and enhancing sinks. With greenhouse gas emissions at the highest levels in human history, this report provides options to achieve net zero, as pledged by many countries. The report highlights for the first time the social and demand-side aspects of climate mitigation, and assesses the literature on human behaviour, lifestyle, and culture, and its implications for mitigation action. It brings a wide range of disciplines, notably from the social sciences, within the scope of the assessment. IPCC reports are a trusted source for decision makers, policymakers, and stakeholders at all levels (international, regional, national, local) and in all branches (government, businesses, NGOs). Available as Open Access on Cambridge Core.

Responding to the sudden and far-reaching implications of the COVID-19 pandemic in college classrooms and on campus, Emerging Stronger assembles an original compilation of chapters that revisit, reframe, and refine the practice of teaching in a fundamentally altered landscape. Cultivated from a wide array of different fields, from sociology and political science to literature and secondary education, expert contributors to this volume extend their scholarship on teaching and learning and offer thoughtful pieces about curricular innovation, teaching tools and techniques, and evidence-based approaches that will interest dedicated faculty in any discipline. The chapters fall into three categories—Modalities of Teaching and Learning, Pedagogical Strategies, and Student Engagement—each of which carry an all-important focus on what readers should know about best practices now and for the foreseeable future. Whether experienced faculty, scholars just starting out in their teaching careers, or aspiring graduate students, readers of this volume will come away with great techniques and strategies, but also community, hope, and opportunity to strengthen their teaching and provide better learning environments in their classrooms.