Phytochemicals from medicinal plants are receiving ever greater attention in the scientific literature, in medicine, and in the world economy in general. For example, the global value of plant-derived pharmaceuticals will reach $500 billion in the year 2000 in the OECD countries. In the developing countries, over-the-counter remedies and "ethical phytomedicines," which are standardized toxicologically and clinically defined crude drugs, are seen as a promising low cost alternatives in primary health care. The field also has benefited greatly in recent years from the interaction of the study of traditional ethnobotanical knowledge and the application of modem phytochemical analysis and biological activity studies to medicinal plants. The papers on this topic assembled in the present volume were presented at the annual meeting of the Phytochemical Society of North America, held in Mexico City, August 15-19, 1994. This meeting location was chosen at the time of entry of Mexico into the North American Free Trade Agreement as another way to celebrate the closer ties between Mexico, the United States, and Canada. The meeting site was the historic Calinda Geneve Hotel in Mexico City, a most appropriate site to host a group of phytochemists, since it was the address of Russel Marker. Marker lived at the hotel, and his famous papers on steroidal saponins from Dioscorea composita, which launched the birth control pill, bear the address of the hotel.

The 3-volume set, Phytochemistry, covers a wide selection of topics in phytochemistry and provides a wealth of information on the fundamentals, new applications, methods and modern analytical techniques, state-of-the-art approaches, and computational techniques. With chapters from professional specialists in their fields from around the world, the volumes deliver a comprehensive coverage of phytochemistry. Phytochemistry is a multidisciplinary field, so this book will appeal to students in both upper-level students, faculty, researchers, and industry professionals in a number of fields, including biological science, biochemistry, pharmacy, food and medicinal chemistry, systematic botany and taxonomy, ethnobotany, conservation biology, plant genetic and metabolomics, evolutionary sciences, and plant pathology.

The powerful, efficient technique of high performance liquid chromatography (HPLC) is essential to the standardization of plant-based drugs, identification of plant material, and creation of new herbal medicines. Filling the void in this critical area, High Performance Liquid Chromatography in Phytochemical Analysis is the first book to give a comp

This book is dedicated to new and important research in the field of phytochemistry which is in the strict sense of the word the study of phytochemicals. These are chemicals derived from plants. In a narrower sense the terms are often used to describe the large number of secondary metabolic compounds found in plants. Many of these are known to provide protection against insect attacks and plant diseases. They also exhibit a number of protective functions for human consumers. Techniques commonly used in the field of phytochemistry are extraction, isolation and structural elucidation (MS,1Dand 2D NMR) of natural products, as well as various chromatography techniques (MPLC, HPLC, LC-MS).

Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products. This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. - Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research - Features clearly illustrated chapters contributed by highly reputable researchers - Covers all key areas in phytochemical research, including virtual screening and metabolomics

Withania is a genus of the nightshade family of flowering plants distributed in the subtropical regions from the Mediterranean to South East Asia. Only two species, W. somnifera and W. coagulans, are found in India. The most common species is W. somnifera (WS), which occurs naturally in the subtropical regions from the Mediterranean through Africa to the Middle East, the Indian Continent, Sri Lanka, South East Asia, subtropical America and Australia. It is a perennial shrub that grows to 75 cm (.75 m) tall with tomentose branches, oval yellowish green leaves, orange red berries and a papery calyx, and it survives harsher climatic conditions. In Ayurveda it is believed the plants which survive harsh conditions have strong healing and tonification properties. The main bioactive phytoconstituents of WS are withanolides (steroidal lactones), alkaloids, flavonoids, sterols, phenolics and others. Among the various withanolides, withanolide A, withaferin A, withanone and withanolide D are the most abundant, having various activities. WS is a wonder herb with a broad spectrum of pharmacological properties, such as antioxidant, antidepressant, aphrodisiac, antiulcerogenic, antivenom, anti-inflammatory, antiarthritic, anticancer, antiparasitic, antimicrobial, anticancerous, antidiabetic, antitumor, hemopoetic neuroregenerative, immunomodulatory, cardioprotective, radio-sensitizing, rejuvenating, antistress, sedative, hypoglycemic, thyroprotective, adaptogenic, antispasmodic, immunomodulatory, immunostimulant and antiaging properties. The simultaneous quantitative analysis of six major bioactive withanolides in five varieties of WS and in different plant parts (root, stem and leaf) of WS was accomplished. This method is also applicable to control the quality of commercially formulated products which contain WS bioactive compounds. Results indicated the WS variety NMITLI-135 showed the maximum abundance of withanolides at pH 8.5, EC-0.5 dS m−1, ESP-13 in sodic soil. Our results showed this readily available, rapid and reliable method is suitable for the routine analysis and effective quality control of raw materials and finished products. FEATURES Presents a collection of Ayurvedic features and scientific analytical and pharmacological evidence of important medicinal plants of Withania somnifera Useful for natural product researchers, faculty, students and herbal product manufacturers Uses advanced hyphenated techniques for assessing phytoconstituents

The "Phytochemical Dictionary of the Leguminosae" is the first of a new type of reference source giving phytochemical records for all legumes (plants in the Pea family - Leguminosae or Fabaceae). The precise chemical substances found, the organs in which they occur (eg the leaf or the seed) and the bibliographic citation are given for each plant species recorded. These are accompanied by extensive supporting botanical, chemical, geographical and bibliographic information for each plant and substance. Over 4,000 chemical substances occurring in 2,000 plant species are contained within 20,000 entries. The Leguminosae is one of the world's most economically important groups of plants, including peas, beans, soya and chickpeas, and provides the world's major source of nitrogen fixed from the atmosphere. As this book contains detailed, comprehensive and up-to-date phytochemical data on this family, available for the first time in a single source, it will prove invaluable to all those working in the food, pharmaceutical and agrochemical industries, as well as in botanical, natural product and taxonomic research. This new work has been compiled as a joint project by two specialist organisations, the International Legume Database & Information Service (ILDIS) and the Chapman & Hall Chemical Database (CHCD). Coverage includes both wild and cultivated species from all over the world. The primary literature used is current to mid-1992. The book is divided into two volumes, the first containing the Plant Section and the second the Chemical Section. The two are linked by extensive cross-referencing and each section has its own indexes. Volume 1 of the dictionary is unique in that it lists not only all legume species from which chemical substances are reported, but also lists under each species what the substances are and in which organs they occur. The substances are grouped together under types of compounds and the original sources are cited. This part is organized alphabetically by genus and species name, followed by a Plant Name Index and Plant Constituent Index. This part of the dictionary may be used in two ways. By selecting a plant species of interest, the reader will see the precise listing of substances reported and the organs in which they occur. Alternatively, by using the Plant Constituent Index, the reader should find a full listing of all legume species from which a particular substance is reported, and from which the main entries for these plant species can be located. Each species entry is annotated with the plant's geographical distribution, its taxonomic details (common name, synonyms used in the phytochemical literature, etc.), botanical data on, for example, life form and economic uses, and reference citations. The problems of nomenclature and synonymy have been overcome for both plant names and substance names. Plant names and classification have been verified using the ILDIS plant taxonomic database: records for the same species originally published under different names are united in the dictionary. Similarly, substance names and classes have been verified using the Chapman & Hall Chemical Database: records for the same substance under different names in the literature are likewise united in the dictionary. Volume 2 is a Chemical Dictionary giving key chemical data on all substances occurring in the Leguminosae, matching those reported in Part 1. This part is taken from the Chapman & Hall Chemical Database and its layout and format is uniform with the renowned Dictionary of Organic Compounds. Each substance has (where appropriate): alternative names, structure diagram, Chemical Abstracts Service (CAS) Registry Number, molecular formula and weight and Type of Compound. These substances are indexed by Chemical Name, Molecular Formula and CAS Registry Number to allow rapid location of the information required.

This book provides an overview of geographic patterns in the distribution of plant secondary metabolites in natural populations. It covers examples within continents, after the ice, intercontinental disjunctions, oceanic islands, and polar disjunctions.

The publication of this volume marks the 40th anniversary of the Recent Advances in Phytochemistry series which has essentially documented a history of the origins of Phytochemistry. The 45th annual meeting of the Phytochemical Society of North America (PSNA) was held July 13-August 3, 2005 in La Jolla, California, USA. The meeting was hosted by the Salk Institute for Biological Studies. The theme of the meeting was – Integrative Plant Biochemistry as we Approach 2010. The focus was "to celebrate the past accomplishments of the PSNA and its focus, the growing importance of phytochemistry and plant biochemistry to the public, and to set a course for the future, by linking the past with the present and attracting a wider breath of scientists and disciplines to the society." Integrative Plant Biochemistry summarizes a number of important methodological approaches and innovative techniques that were discussed at the meeting: - Biosynthesis and Regulation of Signaling Molecules - Conservation and Divergence in Enzyme Function - Translational Opportunities in Plant Biochemistry - Temporal and Spatial Regulation of Metabolism - Lipids, Fatty Acids and Related Molecules - Metabolic Networks Each chapter in this volume concludes with a short summary and addresses the expected future directions of the work. The series marks the transition and progression of the dramatic integration of classical phytochemistry into molecular plant biology. - Explores the growing importance of phytochemistry and biochemistry - Discusses important methodological approaches and innovative techniques - Representation from a unique interdisciplinary forum of scientists at the 45th Annual meeting of the Phytochemical Society of North America