Survival, the IISS’s bimonthly journal, challenges conventional wisdom and brings fresh, often controversial, perspectives on strategic issues of the moment. In this issue: Nick Childs assesses the ambitions and perils of the AUKUS partnership for Australia, the United Kingdom and the United States Kimberly Marten explores how the demise of its key figures will affect future operations of the Wagner Group and similar Russian paramilitaries Steven Feldstein investigates the uses and risks of generative-AI systems From the Survival archives, the late Pierre Hassner interpreted Russia’s August 2008 attack on Georgia as signalling the emergence of a new cold war with the West Dana H. Allin reflects on the European vision advanced by members of a rapidly disappearing generation of scholars who had lived through war and sought to preserve and extend peace And eight more thought-provoking pieces, as well as our regular Book Reviews and Noteworthy column. Editor: Dr Dana Allin Managing Editor: Jonathan Stevenson Associate Editor: Carolyn West Editorial Assistant: Conor Hodges

Survival, the IISS’s bimonthly journal, challenges conventional wisdom and brings fresh, often controversial, perspectives on strategic issues of the moment. In this issue: · Douglas Barrie and Timothy Wright underscore the need for Washington to prioritise qualitative rather than quantitative improvements to its nuclear capabilities – free to read · Catherine Fieschi examines the implications of an indecisive French election · Daniel Byman and Seth G. Jones explore the increasing ties between China, Russia, Iran and North Korea and obstacles to deeper cooperation · Veronica Anghel and Erik Jones examine how the European Union can utilise its most powerful instrument – enlargement – to stabilise its peripheries · And eight more thought-provoking pieces, as well as our regular Book Reviews and Noteworthy column. Editor: Dr Dana Allin Managing Editor: Jonathan Stevenson Associate Editor: Carolyn West Editorial Assistant: Conor Hodges

Central nervous system (CNS) tumors are the eighth leading cause of cancer death and the second most common childhood cancer worldwide. Current treatment methods include surgery, radiation therapy, chemotherapy, targeted therapy, immune therapy etc. However, patients with CNS tumors usually have an unsatisfactory prognosis accompanied by impaired neurologic functions when compared with other cancers. Few drugs or treatments have been proven effective in CNS tumors due to the presence of blood-brain barriers and its distinctive tumor microenvironment.

As a leading Open Access publisher, Frontiers is committed to empowering not only scientists, but other researchers, innovators and members of the public. As such, highlighting sustainable development and the real-world applications of Drugs Outcomes Research & Policies are a key part to the agenda of Frontiers in Pharmacology. This Research Topic aims to highlight advancements in Health Economics and Outcomes Research (HEOR) techniques, methods and tools used by the pharmaceutical industry and other non-academic bodies.

National pension systems face a range of tough social and economic demands and pressures. These are complex to navigate, especially in a twenty-first century world that has ushered in global uncertainty and pressing challenges - even threatening the planet’s very sustainability – with implications for pensions that policymakers, financial services providers and individuals themselves must address. This book probes, and unpacks, what pension systems aim to achieve, the uncertainties they face and how they are attempting to resolve them. Analysing pension provision from the systemic, political-economy and individual perspectives, it sets out and contextualises commonalities and differences in pension systems across the globe, looking at current developments in both public and private pension provision, structures and regulation. Moreover, the reader is encouraged to question how national pension systems can best serve their populations and ensure the ‘sustainability’ of later-life incomes in the light of today’s global pension challenges. Global Pension Challenges: Pensions, Saving and Retirement in the Twenty‐First Century is an essential read for business, finance and social-policy academics and students, those working in the pensions industry and in the areas of welfare reform and advocacy, as well as the general public wishing to know more about the retirement issues we will all face in the coming years.

These proceedings represent the work of contributors to the 19th International Conference on Cyber Warfare and Security (ICCWS 2024), hosted University of Johannesburg, South Africa on 26-27 March 2024. The Conference Chair was Dr. Jaco du Toit, University of Johannesburg, South Africa, and the Program Chair was Prof Brett van Niekerk, from Durban University of Technology. South Africa. ICCWS is a well-established event on the academic research calendar and now in its 19th year, the key aim remains the opportunity for participants to share ideas and meet the people who hold them. The scope of papers will ensure an interesting two days. The subjects covered this year illustrate the wide range of topics that fall into this important and ever-growing area of research.

This book addresses the regulation of hybrid warfare under relevant branches of international law, beginning with the law on inter-state use of force (jus ad bellum). Firstly, the book assesses the extent to which forms of hybrid warfare comply with or violate international humanitarian law/the law of armed conflict. It then looks at law enforcement action in response to hybrid warfare, both on land and on the high seas, and addresses hybrid warfare from the perspective of international counterterrorism law. It goes on to tackle the constraints applied to hybrid warfare under international human rights law, and looks at how hybrid warfare could be constrained under disarmament law. The final two chapters look at accountability for the conduct of hybrid warfare, concluding with the question: can we move towards a less fragmented set of international legal rules that will govern hybrid warfare in the future?

Discover the legacy of Robin Mathews, an influential rabble-rouser, provocateur, and patriot who challenged Canada's elites and inspired a distinct Canadian identity. In this collection of eight original essays, contributors such as Daniel Drache, Pat Smart, Duncan Cameron, and Susan Crean delve into Mathews' profound impact on Canadian politics and culture from the late 1960s to the early 1990s. Mathews passionately debated corporate takeovers, foreign control of trade unions, media ownership, and cultural sovereignty. His charismatic presence and relentless energy galvanized students, professors, politicians, and artists across the country. This collection captures his tireless efforts to promote cultural literacy and economic independence, contributing to the growth of Canadian studies, the Canadian trade union movement, and the Great Canadian Theatre Company.Explore Mathews' enduring influence through insightful essays that celebrate his contributions to Canada's national identity and cultural landscape.

Harlequin® Romance brings you a collection of four new titles, available now! Experience the rush of falling in love! This Harlequin® Romance box set includes: MISTLETOE MAGIC IN TAHITI The Christmas Pact By Kandy Shepherd Recently divorced Sienna is spending Christmas on a Tahitian beach! First stop on her ‘new me’ journey? Surf lessons with blazing hot magnate Kai—and adding fling to her itinerary! But Sienna didn’t expect to fall for the single dad… Will she walk away from a magical future—together? CINDERELLA’S COSTA RICAN ADVENTURE The Christmas Pact By Scarlet Wilson After her sheltered upbringing, Eliza’s exploring her adventurous side in Costa Rica! Only her dream vacation is hijacked by gorgeous, brooding resort owner, Matt. But, stranded in a cave on Christmas Eve, they can’t hide their vulnerabilities. Can they encourage each other to grab life with both hands? HAWAIIAN NIGHTS WITH THE BEST MAN Blossom and Bliss Weddings By Cara Colter When a tropical storm descends after her sister’s wedding, Bliss finds herself tantalizingly trapped with best man, ex-special forces billionaire Lance. But Bliss’s unpredictable childhood has left her wary of getting close to anyone. Until the consequences of their Hawaiian nights upend both their worlds… THE CHRISTMAS THAT CHANGED EVERYTHING By Faye Acheampong When The Entertainment Emporium’s Santa falls ill, toy shop manager Naomi needs a stand-in—quick! And buttoned-up accountant, Will, is her only option... Forced to spend the festive season together, in heart-racing proximity, Naomi starts to see the real Will. Dare she let him unwrap her guarded heart?

Traditionally, surgery, radiotherapy, chemotherapy and hormonal therapy have been used in clinical practice to treat cancer patients. However, these methods are either not completely tumor free or without collateral damage to health tissues. Therefore, tumor recurrence, partial remission, treatment side effect and poor tolerance in elderly patients, and lack of effective strategy to treat late-stage cancers have been the major hurdles faced by clinicians in health care. Although cancer immunotherapy including checkpoint blockade, CAR-T, oncolytic viruses, and recombinant cytokines has taken center stage in mainstream oncology because of its specifically targeting tumor cells without affecting surrounding normal cells, only a proportion of patients receiving treatment respond and others relapse after an initial response. Different tumor indications respond differently, and even in cancer types that respond, unresponsiveness are still observed. This resistance suggests that either lack of sufficient host recognition and immunity (intrinsic) or active immune suppression by tumor complex (acquired).