Covering advanced nutrition with a comprehensive, easy-to-understand approach, Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 3rd Edition focuses on the biology of human nutrition at the molecular, cellular, tissue, and whole-body levels. It addresses nutrients by classification, and describes macronutrient function from digestion to metabolism. This edition includes the new MyPlate dietary guide and recommendations from the Dietary Guidelines for Americans 2010, plus coverage of the historical evolution of nutrition and information on a wide range of vitamins, minerals, and other food components. In Biochemical, Physiological, and Molecular Aspects of Human Nutrition, lead authors Martha H. Stipanuk and Marie A. Caudill are joined by a team of nutrition experts in providing clear, concise, coverage of advanced nutrition. - 55 expert contributors provide the latest information on all areas of the nutrition sciences. - Nutrition Insight boxes discuss hot topics and take a closer look at basic science and everyday nutrition. - Clinical Correlation boxes show the connection between nutrition-related problems and their effects on normal metabolism. - Food Sources boxes summarize and simplify data from the USDA National Nutrient Database on the amount and types of foods needed to reach the recommended daily allowances for vitamins and minerals. - DRIs Across the Life Cycle boxes highlight the latest data from the Institute of Medicine on dietary reference intakes for vitamins and minerals, including coverage of infants, children, adult males and females, and pregnant and lactating women. - Life Cycle Considerations boxes highlight nutritional processes or concepts applicable to individuals of various ages and in various stages of the life span. - Thinking Critically sections within boxes and at the end of chapters help in applying scientific knowledge to "real-life" situations. - Lists of common abbreviations provide an overview of each chapter's content at a glance. - Comprehensive cross-referencing by chapters and illustrations is used throughout. - Current references and recommended readings connect you to nutrition-related literature and provide additional tools for research. - Coverage of the USDA's MyPlate dietary guide reflects today's new approach to diet and nutrition. - Recommendations outlined in the Dietary Guidelines for Americans 2010 are incorporated throughout the book. - Updated format features more subheadings, tables, and bullets, making it easier to learn and recall key points. - Updates of key chapters and boxes reflect significant changes within the fields of nutrition, biology, molecular biology, and chemistry. - NEW illustrations simplify complex biochemical, physiological, and molecular processes and concepts.

This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Provides information on ways women can protect themselves and fight breast cancer, covering such topics as healthy eating, supplements, exercise, medications, meditation, and emotional healing.

First multi-year cumulation covers six years: 1965-70.

This handbook addresses the delivery of high quality pediatric behavioral healthcare services that are multitiered, evidence-based, and integrated, involving interprofessional collaboration across child serving systems, such as pediatrician offices and schools. The book sets forth a contemporary, leading edge approach that reflects the relationship between biological and psychosocial development and the influence of multiple systems, including the family, community, school, and the healthcare system on child development and functioning. It assists child-focused providers in developing knowledge about the relationship between biological and psychosocial development and between pediatric physical health and behavioral health problems. Chapters cover common chronic illnesses and behavioral conditions and include guidelines for screening, assessment, diagnosis, prevention, and coordinated intervention. Chapters also include representative case studies that help illustrate efficacious, effective service-delivery approaches. The handbook concludes with recommendations for future research and directions for integrated pediatric behavioral healthcare. Topics featured in the Handbook include: Behavioral health aspects of chronic physical health conditions, including asthma, diabetes, chronic pain, traumatic brain injury, and cancer. Physical health implications of behavioral health and educational problems, including ADHD, learning disabilities, substance abuse, and ASD. Coping with chronic illness and medical stress. Patient adherence to medical recommendations and treatments. School reintegration after illness. The Handbook of Pediatric Behavioral Healthcare is a must-have resource for researchers, professors, and graduate students as well as clinicians, therapists, and other practitioners in clinical child and school psychology, primary care medicine, social work, child and adolescent psychiatry, public health, health psychology, pediatric medicine, nursing, behavioral therapy, rehabilitation, and counseling.

This edited volume Prostate Cancer is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of urologic oncology. The book comprises single chapters authored by various researchers and edited by an expert active in the urologic oncology research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors and opens new possible research paths for further novel developments.