Advancing the Research Agenda for DSM-V, Diagnostic Issues in Dementia comprises nine chapters with research suggestions for consideration for the upcoming DSM-V process, reflecting the nascent effort toward a new diagnostic nomenclature in the still rapidly evolving field of dementia. Here, 18 experts provide critical pieces of the dementia diagnostic story: The all-important neuropathological criteria of Alzheimer's disease and the aging brain; current epidemiologic literature and the challenges of making even minor changes in the general definition of dementia; and a scholarly review of the diagnostic nomenclature across the existing criteria, with numerous critiques and suggestion for future research The growing evidence for mild cognitive impairment as an identifiable entity suitable for inclusion in DSM-V; the current neuropsychological profiling that serves as the centerpiece of the diagnostic criteria for dementia and suggests that new instruments evaluating even broader aspects of cognition, including executive function, will be important in helping to identify dementia at an earlier stage of development The various behavioral syndromes associated with dementia, with emphasis on the need for great diagnostic clarity to help focus appropriate therapy in this area of increased burden for patients and family caregivers Biomarkers in dementia that may already be appropriate for inclusion in our diagnostic criteria; the current diagnostic utility of specific imaging modalities, which, combined with expanding ligand technology or markers of genetic predisposition, might further enhance diagnostic accuracy A review of the tremendous explosion of information in this field, asserting that, with the exception of the rare Mendelian disorders, genetic profiles are not yet ready to make substantial contributions to nosology Despite all of these exciting findings, the editors state that we are still dealing with primarily clinical syndromes and therefore are still using clinical diagnostic criteria established at consensus conferences. In the spirit of scientific humility, they assert that these experts' views must be considered within the vast and expanding literature related to the dementias. Given the associated but still generally nonspecific biological mechanisms underlying these syndromes, new scientific developments might occur at any time and immediately affect the interpretations and considerations presented here. This remarkably concise and insightful collection reviews today's -- and suggests directions for tomorrow's -- important diagnostic and research issues in dementia, and as such is a "must read" for clinicians and researchers alike.

This volume provides a comprehensive guide to the manifestations and pathogenesis involved with stroke, including advancements in research and a newfound understanding of the biochemical background of this cerebrovascular disorder. This intensive handbook is meant to give clinicians a source reference that will enable them to gain a thorough knowledge and understanding of the clinical features and management of the many neurological manifestations of stroke disorder. In addition, practitioners, clinicians, and researchers will gain a better understanding of highly studied topics, including amongst others, the medical complications associated with stroke, chapters on anterior circulation and hemorrhagic stroke syndromes, stroke related psychiatric disorders, and other rare causes of stroke disorder.

Dementia represents a major public health challenge for the world with over 100 million people likely to be affected by 2050. A large body of professionals is active in diagnosing, treating, and caring for people with dementia, and research is expanding. Many of these specialists find it hard to keep up to date in all aspects of dementia. This book helps solve that problem. The new edition has been updated and revised to reflect recent advances in this fast-moving field.

Discusses the spectrum of dementing disorders and explains their overlap, presentations, and differential diagnosis. The chapters present original data as well as material from the authors' clinical experiences. Current classification systems are evaluated and modified to better account for common presentations of dementia. Includes new material on neuroimaging, genetics, the role of inflammation in Alzheimer disease, retrophylogenesis in Alzheimer memory, and AIDS dementia.

The sixth edition of this popular favorite is ideal for board review, as well as for clinical reference on neurologic illnesses that can cause or mimic psychiatric symptoms. First it reviews anatomic neurology, describes how to approach patients with suspected neurologic disorders and correlates physical signs. Then it addresses clinical areas such as relevant history, easily performed examinations, differential diagnosis, and management approaches, and reviews psychiatric comorbidity. Abundant line drawings, CTs, MRIs, and EEGs demonstrate key clinical findings to facilitate diagnosis. And, more than 1,600 review questions help you to test and enhance your mastery of the material. Describes each condition's relevant history, neurologic and psychiatric features, easily performed office and bedside examinations, appropriate tests, differential diagnosis, and management options. Includes over 1,600 review questions and cases to help you prepare for the neurology section of the Psychiatry Board exam. Uses an accessible writing style and a logical, easy-to-reference organization. Includes reviews of public policy towards neurologic conditions, such as the persistent vegetative state and use of narcotics for chronic pain, important practice issues you may face. Offers thorough updates and the following NEW topics: Descriptions of altered mental status, including the minimally responsive state and minimal cognitive impairment Neurotoxins, including marine toxins Nutritional deficiencies and errors of metabolism, especially involving homocysteine Psychiatric co-morbidity of epilepsy, migraine, multiple sclerosis, Parkinson's disease, stroke, Tourette's disease, and other neurologic illnesses Standard clinical assessment tools, such as the Alzheimer's Disease Assessment Scale Cognitive Section (ADAS-Cog) and the Epworth Sleepiness Scale Recently introduced treatments for common neurologic illnesses: * Deafness: cochlear implant * Epilepsy: antiepileptic drugs, deep brain stimulation, and vagus nerve stimulation *Involuntary movements: deep brain stimulation * Multiple sclerosis: immunomodulators and their complications * Chronic pain: stimulators, opioid maintenance, adjuvant medications * Uses of psychiatric medications for neurologic illnesses, such as antidepressants for migraine, chronic pain, and peripheral neuropathy; and antipsychotic agents for dementia and epilepsy Improved art program that better highlights clinicalclues. A new two-color format.

Dementia is amongst the greatest challenges facing the medical profession as the population ages. Accurate diagnosis is essential as many rarer forms of the disease are treatable if recognized early. This collection of case studies from around the world illustrates both common and unusual causes of dementia, emphasizing clinical reasoning, integrative thinking and problem-solving skills. Each case consists of a clinical history, examination findings and special investigations, followed by diagnosis and discussion. The aim is to reinforce diagnostic skills through careful analysis of individual presenting patterns, and to guide treatment decisions, using state-of-the-art diagnostic classification and tools. The reader will be able to distinguish patients who need reassurance, closer follow-up or immediate referral to specialized services. Written and edited by internationally recognized experts in dementia, these case studies will inform and challenge clinicians at all stages of their careers.

The third edition of this successful textbook has been completely updated throughout and includes new chapters on electrophysiological tests, biological markers, global staging measures, and management of neuropsychiatric symptoms. There has been steady progress in our understanding of the natural history, prognostic factors and treatments for Alzh

The rising prevalence of dementia in the population continues to pose a serious public health challenge in both the developed and the developing world. Previous editions of Dementia have become acknowledged as a key 'gold standard' work in this field, and have had a genuinely international approach. The third edition has been fully revised and updated to reflect the most recent advances in the rapidly developing field of dementia research, adding further important detail to this already authoritative and detailed text. New material on mild cognitive impairment has been included, and the latest developments in areas such as service development and carer research are also covered. All the chapters have been revised to include the most up-to-date research in their field. This is an essential work of reference for specialists in old age psychiatry, neurology, and health care of the elderly. It should also be a useful resource for others working with patients with dementia, including general practitioners, nurses, psychologists, and other allied health professionals.

The era of therapeutic nihilism in dementia has ended, with the emergence of agents for symptomatic treatment, those that delay the course of the disease or prevent the onset of dementia, and new methods to manage symptoms. With the expansion of therapies, there is a clear danger of being overwhelmed by the volume of data. This book is designed to collect this information, distil what is relevant and reliable, and present it in a format that is useful to clinicians who manage and treat people with dementia. The book is designed to bring together the latest, best and practical evidence on all aspects of management, from diagnosis and therapy to social and ethical considerations. The editors are all dynamic clinicians involved in the care of patients with dementia and the evaluation of therapies. Two of the editors are the leaders of the Cochrane Collaboration for the examination of therapies for dementia. There are no other books that take such a practical and problem-oriented or approach to the diagnosis and management of dementia. Furthermore none but this can be described as truely evidence-based.