When funding agencies and policy organizations consider the role of modeling and simulation in modern biology, the question is often posed, what has been accomplished ? This book will be organized around a symposium on the 20 year history of the CNS meetings, to be held as part of CNS 2010 in San Antonio Texas in July 2010. The book, like the symposium is intended to summarize progress made in Computational Neuroscience over the last 20 years while also considering current challenges in the field. As described in the table of contents, the chapter’s authors have been selected to provide wide coverage of the applications of computational techniques to a broad range of questions and model systems in neuroscience. The proposed book will include several features that establish the history of the field. For each article, its author will select an article originally appearing in a CNS conference proceedings from 15 – 20 years ago. These short (less than 6 page) articles will provide illustrations of the state of the field 20 years ago. The new articles will describe what has been learned about the subject in the following 20 years, and pose specific challenges for the next 20 years. The second historical mechanism will be the reproduction of the first 12 years of posters from the CNS meeting. These posters in and of themselves have become famous in the field (they hang in the halls of the NIH in Bethesda Maryland) and were constructed as allegories for the state and development of computational neuroscience. The posters were designed by the book’s editor, who will, for the first time, provide a written description of each poster.

The two volumes LNCS 9107 and 9108 constitute the proceedings of the International Work-Conference on the Interplay Between Natural and Artificial Computation, IWINAC 2015, held in Elche, Spain, in June 2015. The total of 103 contributions was carefully reviewed and selected from 190 submissions during two rounds of reviewing and improvement. The papers are organized in two volumes, one on artificial computation and biology and medicine, addressing topics such as computational neuroscience, neural coding and neuro-informatics, as well as computational foundations and approaches to the study of cognition. The second volume deals with bioinspired computation in artificial systems; topics alluded are bio-inspired circuits and mechanisms, bioinspired programming strategies and bioinspired engineering AI&KE.

This volume includes contributions from diverse disciplines including electrical engineering, biomedical engineering, industrial engineering, and medicine, bridging a vital gap between the mathematical sciences and neuroscience research. Covering a wide range of research topics, this volume demonstrates how various methods from data mining, signal processing, optimization and cutting-edge medical techniques can be used to tackle the most challenging problems in modern neuroscience.

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases. Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways. Contributions from leading authorities Informs and updates on all the latest developments in the field

As predicted by Gordon E. Moore in 1965, the performance of computer processors increased at an exponential rate. Nevertheless, the increases in computing speeds of single processor machines were eventually curtailed by physical constraints. This led to the development of parallel computing, and whilst progress has been made in this field, the complexities of parallel algorithm design, the deficiencies of the available software development tools and the complexity of scheduling tasks over thousands and even millions of processing nodes represent a major challenge to the construction and use of more powerful parallel systems. This book presents the proceedings of the biennial International Conference on Parallel Computing (ParCo2015), held in Edinburgh, Scotland, in September 2015. Topics covered include computer architecture and performance, programming models and methods, as well as applications. The book also includes two invited talks and a number of mini-symposia. Exascale computing holds enormous promise in terms of increasing scientific knowledge acquisition and thus contributing to the future well-being and prosperity of mankind. A number of innovative approaches to the development and use of future high-performance and high-throughput systems are to be found in this book, which will be of interest to all those whose work involves the handling and processing of large amounts of data.

The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as many different experimental preparations and theoretical approaches. The papers published here range from pure experimental neurobiology, to neuro-ethology, mathematics, physics, and engineering. In all cases the research described is focused on understanding how nervous systems compute. The actual subjects of the research include a highly diverse number of preparations, modeling approaches and analysis techniques. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

Trains researchers and graduate students in state-of-the-art statistical and machine learning methods to build models with real-world data.

Unveil the next frontier in neurodegenerative disorder research with Integrating Neuroimaging, Computational Neuroscience, and Artificial Intelligence. This groundbreaking book goes beyond traditional approaches, utilizing the power of interdisciplinary integration to illuminate new pathways in diagnosis and treatment. From AI-driven diagnostics to computational neuroscience models, this book showcases the forefront of innovation. Join us in exploring the future of neurodegenerative care, where collaboration and cutting-edge technology converge to redefine possibilities. Key Features: Integrates diverse fields of research, from neuroimaging to computational neuroscience and Artificial Intelligence. Emphasizes the translation of research findings into practical applications, ultimately benefitting patients and clinical practice. Reviews the implementation of Artificial Intelligence and computational models in diagnostic settings. Elucidates the current state of translational neuroscience exploring potential areas for further research and collaboration, including personalized treatments and drug development. Contributions from an international team of experts from diverse disciplines.