This report describes an interdisciplinary effort to apply the techniques of operations research and energy system modeling to a problem of concern to the nuclear-electric power system, namely, determination of cost-effective strategies for capacity expansion of the domestic nuclear fuel reprocessing industry for the 1975-2000 time period. The research also determines cost disadvantages associated with alternative strategies which may be attractive for political, social, or ecological reasons. The sensitivity of results to changes in cost assumptions is investigated at some length.