Design and execute life-saving trials with this accessible resource Clinical trials have revolutionized the treatment of disease and the development of life-saving pharmaceuticals. They contribute decisively to diagnosis, the avoidance of early death, medical intervention and are central to the modern work of pharmaceutical producers. The design and execution of clinical trials is one of the fastest-growing and most important areas of medical and pharmaceutical research. A Concise Guide to Clinical Trials provides an accessible and comprehensive survey of clinical trials, their design, and their applications. Beginning with a taxonomy of trial types, the book overviews stages of analysis, ethical and legal requirements, and more. Now fully updated to reflect the latest research and clinical practice, it continues to be an indispensable resource for researchers and clinicians. Readers of the second edition of A Concise Guide to Clinical Trials will also find: New material on pharmaceutical trials, adaptive designs, and the use of “big data” The easy-to-use organization facilitates both first-time learning and reference Detailed treatment of concepts such as health technology assessments (HTA), patient and public involvement and engagement (PPIE), and more A Concise Guide to Clinical Trials is ideal for clinicians and healthcare professionals looking for a working knowledge of clinical trials, as well as for pharmaceutical workers and regulators looking to understand this vital aspect of the industry.

A Concise Guide to Observational Studies in Healthcare provides busy healthcare professionals with an easy-to-read introduction and overview to conducting, analysing and assessing observational studies. It is a suitable introduction for anyone without prior knowledge of study design, analysis or conduct as the important concepts are presented throughout the text. It provides an overview to the features of design, analyses and conduct of observational studies, without using mathematical formulae, or complex statistics or terminology and is a useful guide for researchers conducting their own studies, those who participate in studies co-ordinated by others, or who read or review a published report of an observational study. Examples are based on clinical features of people, biomarkers, lifestyle habits and environmental exposures, and evaluating quality of care.

Biopharmaceutical drugs improve the health and well-being of people across the globe on a scale that is unrivaled by any other medical intervention. Before these drugs can be prescribed for patients by their doctors, they have to be approved for marketing by a regulatory agency. To gain marketing approval, drugs must go through an extremely rigorous process that investigates their safety and efficacy, the process of New Drug Development. The last stage of this long, complex, and expensive process involves conducting clinical trials, the topic of this book. Successfully conducting clinical trials requires the interdisciplinary collaboration of individuals from many clinical and scientific disciplines and areas of operational expertise. These include medicine, information technology, ethics and law, statistics, clinical trial operations, data collection and management, regulatory science, and medical writing, to name just a few. Central aspects of conducting clinical trials are discussed in the following chapters, with the goals of making specialists from each of these areas aware of the contributions of their colleagues, and helping readers to appreciate that everyone involved in clinical research is working side-by-side toward a common goal---improving the health, well-being, and longevity of millions of patients around the globe.

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This handbook will be a concise guide to important topics in psychiatry with an international focus. It constitutes a précis of the field of psychiatry with emphases on the therapeutic approach to the patient and on the proper diagnosis of major psychiatric disorders.All psychiatric diagnoses are encoded using both the US Diagnostic and Statistical Manual (DSM) and the International Statistical Classification of Diseases and Related Health Problems (ICD). Treatment options for psychiatric disorders will include approaches used in developed nations in North America, Europe, Asia, as well as in the developing world. Furthermore an invaluable brief history of psychiatry allows readers to trace the beginnings of their chosen field and gain awareness of the ethical and legal contexts.This handbook will provide a comprehensive introduction to psychiatry appropriate for students, trainees, and practitioners seeking an international approach.

"This third edition of this popular pocket guide is updated throughout, featuring new medications and new diagnostic procedures and criteria. Like the previous editions, it presents brief synopses of the major neuropsychiatric and neurobehavioral syndromes, discusses their clinical assessment, and provides guidelines for management. The authors summarize diagnostic and treatment information in easy-to-read tables, including clinical features, underlying pathophysiology, and treatment options for the major neuropsychiatric disorders. They cover everything from assessment (e.g., testing, brain imaging) and relevant neurophysiology and neuropsychiatry symptoms and syndromes (e.g., frontal lobe, aphasia and related syndromes) to individual diseases (e.g., right-brain disorders, memory disorders, epilepsy/limbic system disorders, dementia and delirium, movement disorders, stroke and brain tumors, white matter diseases and inborn errors of metabolism, and head injury) and the latest treatments (e.g., neuropsychopharmacology, electroconvulsive therapy, vagus nerve stimulation, and neurosurgical procedures). An immediately useful clinical companion for psychiatrists and geriatric psychiatrists, neurologists, and neuropsychologists both within the U.S. and abroad, this volume is also exceptionally practical for students and residents because of its broad scope and easily accessible information"--

Clinical trials have revolutionized the way disease is prevented, detected and treated, and early death avoided, and they continue to be an expanding area of research. They are central to the work of pharmaceutical companies, and there are many academic and public sector organizations that conduct trials on a wide variety of interventions, including drugs, devices, surgical techniques, and changes in behaviour and lifestyle. A Concise Guide to Clinical Trials provides a comprehensive yet easy-to-read overview of the design, conduct and analysis of trials. It requires no prior knowledge on the subject as the important concepts are introduced throughout. There are chapters that distinguish between the different types of trials, and an introduction to systematic reviews, health-related quality of life and health economic evaluation. The book also covers the ethical and legal requirements in setting up a clinical trial due to an increase in governance responsibilities and regulations. This practical guidebook is ideal for busy clinicians and other health professionals who do not have enough time to attend courses or search through extensive textbooks. It will help anyone involved in undertaking clinical research, or those reading about trials. The book is aimed at: Those wishing to learn about clinical trials for the first time, or as a quick reference guide, for example as part of a taught course on clinical trials Health professionals who wish to conduct their own trials, or participate in other people’s studies People who work in pharmaceutical companies, grant funding organisations, or regulatory agencies

This pocket-sized, practical reference summarizes everything you need to know to diagnose and treat unipolar and bipolar mood disorders. Designed for daily use in the clinical setting, the Concise Guide to Mood Disorders is a fingertip library of the latest information; easy to understand and quick to access. Praised by practitioners, the Concise Guides Series from American Psychiatric Publishing Inc. was developed to disburse a great deal of practical information in a convenient format. Features of the Concise Guide to Mood Disorders include: One-stop, comprehensive guidance. Never again will you have to search several resources to find answers to your questions about mood disorders. The Concise Guide to Mood Disorders presents all the essential information you need on epidemiology, etiology, physical treatments, psychosocial treatments, outcomes, and comorbidity in a single source. Easy and quick reference. This handy resource is organized to give you fast, easy access to information -- a necessity in daily practice. The detailed table of contents and key word index enable you to pinpoint the facts you need in seconds. Charts, tables, and other graphic representations help you comprehend information quickly. The latest research findings presented for practical use. Here are the most current research results, distilled and presented in easy-to-understand language for practical application with patients. Some information appears in the Concise Guide to Mood Disorders for the first time anywhere. The Concise Guide to Mood Disorders is the best reference tool you'll find for making informed decisions that lead to better clinical outcomes. Psychiatrists, psychologists, primary care physicians, and any other clinical professionals who diagnose and treat patients with mental health disorders should have this authoritative reference on hand.

A concise review of current research into suicide providing a guide to understanding this disease and its increasing incidence globally.