“Thought-provoking…any scientist interested in genetics will find this an enlightening look at the history of this field.”—Quarterly Review of Biology It was only around 1800 that heredity began to enter debates among physicians, breeders, and naturalists. Soon thereafter, it evolved into one of the most fundamental concepts of biology. Here, Staffan Muller-Wille and Hans-Jorg Rheinberger offer a succinct cultural history of the scientific concept of heredity. They outline the dramatic changes the idea has undergone since the early modern period and describe the political and technological developments that brought about these changes. They begin with an account of premodern theories of generation, showing that these were concerned with the procreation of individuals rather than with hereditary transmission, and reveal that when hereditarian thinking first emerged, it did so in a variety of cultural domains, such as politics and law, medicine, natural history, breeding, and anthropology. The authors then track theories of heredity from the late nineteenth century—when leading biologists considered it in light of growing societal concerns with race and eugenics—through the rise of classical and molecular genetics in the twentieth century, to today, as researchers apply sophisticated information technologies to understand heredity. What we come to see from this exquisite history is why it took such a long time for heredity to become a prominent concept in the life sciences, and why it gained such overwhelming importance in those sciences and the broader culture over the last two centuries.

Investigations of how the understanding of heredity developed in scientific, medical, agro-industrial, and political contexts of the late nineteenth and early twentieth centuries. This book examines the wide range of scientific and social arenas in which the concept of inheritance gained relevance in the late nineteenth and early twentieth centuries. Although genetics emerged as a scientific discipline during this period, the idea of inheritance also played a role in a variety of medical, agricultural, industrial, and political contexts. The book, which follows an earlier collection, Heredity Produced (covering the period 1500 to 1870), addresses heredity in national debates over identity, kinship, and reproduction; biopolitical conceptions of heredity, degeneration, and gender; agro-industrial contexts for newly emerging genetic rationality; heredity and medical research; and the genealogical constructs and experimental systems of genetics that turned heredity into a representable and manipulable object. Taken together, the essays in Heredity Explored show that a history of heredity includes much more than the history of genetics, and that knowledge of heredity was always more than the knowledge formulated as Mendelism. It was the broader public discourse of heredity in all its contexts that made modern genetics possible. Contributors Caroline Arni, Christophe Bonneuil, Christina Brandt, Luis Campos, Jean-Paul Gaudillière, Bernd Gausemeier, Jean Gayon, Veronika Lipphardt, Ilana Löwy, J. Andrew Mendelsohn, Staffan Müller-Wille, Diane B. Paul, Theodore M. Porter, Alain Pottage, Hans-Jörg Rheinberger, Marsha L. Richmond, Helga Satzinger, Judy Johns Schloegel, Alexander von Schwerin, Hamish G. Spencer, Ulrike Vedder

Bonduriansky and Day challenge the premise that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. They explore the latest research showing that what happens during our lifetimes--and even our parents' and grandparents' lifetimes--can influence the features of our descendants. Based on this evidence, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations, opening the door to a new understanding of inheritance, evolution, and even human health. --Adapted from publisher description.

The cultural history of heredity: scholars from a range of disciplines discuss the evolution of the concept of heredity, from the Early Modern understanding of the act of "generation" to its later nineteenth-century definition as the transmission of characteristics across generations. Until the middle of the eighteenth century, the biological makeup of an organism was ascribed to an individual instance of "generation"--involving conception, pregnancy, embryonic development, parturition, lactation, and even astral influences and maternal mood--rather than the biological transmission of traits and characteristics. Discussions of heredity and inheritance took place largely in the legal and political sphere. In Heredity Produced, scholars from a broad range of disciplines explore the development of the concept of heredity from the early modern period to the era of Darwin and Mendel. The contributors examine the evolution of the concept in disparate cultural realms--including law, medicine, and natural history--and show that it did not coalesce into a more general understanding of heredity until the mid-nineteenth century. They consider inheritance and kinship in a legal context; the classification of certain diseases as hereditary; the study of botany; animal and plant breeding and hybridization for desirable characteristics; theories of generation and evolution; and anthropology and its study of physical differences among humans, particularly skin color. The editors argue that only when people, animals, and plants became more mobile--and were separated from their natural habitats through exploration, colonialism, and other causes--could scientists distinguish between inherited and environmentally induced traits and develop a coherent theory of heredity. Contributors David Sabean, Silvia De Renzi, Ulrike Vedder, Carlos López Beltrán, Phillip K. Wilson, Laure Cartron, Staffan Müller-Wille, Marc J. Ratcliff, Roger Wood, Mary Terrall, Peter McLaughlin, François Duchesneau, Ohad Parnes, Renato Mazzolini, Paul White, Nicolas Pethes, Stefan Willer, Helmuth Müller-Sievers

Written by 30 authors from all over the world, this book provides a unique overview of exciting discoveries and surprising developments in human genetics over the last 50 years. The individual contributions, based on seven international workshops on the history of human genetics, cover a diverse range of topics, including the early years of the discipline, gene mapping and diagnostics. Further, they discuss the status quo of human genetics in different countries and highlight the value of genetic counseling as an important subfield of medical genetics.

A revealing look at how the memory of the plague held the poor responsible for epidemic disease in eighteenth-century Britain Britain had no idea that it would not see another plague after the horrors of 1666, and for a century and a half the fear of epidemic disease gripped and shaped British society. Plague doctors had long asserted that the bodies of the poor were especially prone to generating and spreading contagious disease, and British doctors and laypeople alike took those warnings to heart, guiding medical ideas of class throughout the eighteenth century. Dense congregations of the poor—in workhouses, hospitals, slums, courtrooms, markets, and especially prisons—were rendered sites of immense danger in the public imagination, and the fear that small outbreaks might run wild became a profound cultural force. Extensively researched, with a wide body of evidence, this book offers a fascinating look at how class was constructed physiologically and provides a new connection between the seventeenth and nineteenth centuries and the ravages of plague and cholera, respectively.

This pioneering work is the first to trace how our understanding of the causes of human behavior has changed radically over the course of European and American cultural history since 1830. Focusing on the act of murder, as documented vividly by more than a hundred novels including Crime and Punishment, An American Tragedy, The Trial, and Lolita, Stephen Kern devotes each chapter of A Cultural History of Causality to examining a specific causal factor or motive for murder--ancestry, childhood, language, sexuality, emotion, mind, society, and ideology. In addition to drawing on particular novels, each chapter considers the sciences (genetics, endocrinology, physiology, neuroscience) and systems of thought (psychoanalysis, linguistics, sociology, forensic psychiatry, and existential philosophy) most germane to each causal factor or motive. Kern identifies five shifts in thinking about causality, shifts toward increasing specificity, multiplicity, complexity, probability, and uncertainty. He argues that the more researchers learned about the causes of human behavior, the more they realized how much more there was to know and how little they knew about what they thought they knew. The book closes by considering the revolutionary impact of quantum theory, which, though it influenced novelists only marginally, shattered the model of causal understanding that had dominated Western thought since the seventeenth century. Others have addressed changing ideas about causality in specific areas, but no one has tackled a broad cultural history of this concept as does Stephen Kern in this engagingly written and lucidly argued book.

The Enlightenment commitment to reason naturally gave rise to a belief in the perfectibility of man. Influenced by John Locke and Jean-Jacques Rousseau, many eighteenth-century writers argued that the proper education and upbringing breeding could make any man a member of the cultural elite. Yet even in this egalitarian environment, the concept of breeding remained tied to theories of blood lineage, caste distinction, and biological difference. Turning to the works of Locke, Rousseau, Swift, Defoe, and other giants of the British Enlightenment, Jenny Davidson revives the debates that raged over the husbandry of human nature and highlights their critical impact on the development of eugenics, the emergence of fears about biological determinism, and the history of the language itself. Combining rich historical research with a keen sense of story, she links explanations for the physical resemblance between parents and children to larger arguments about culture and society and shows how the threads of this compelling conversation reveal the character of a century. A remarkable intellectual history, Breeding not only recasts the fundamental concerns of the Enlightenment but also uncovers the seeds of thought that bloomed into contemporary notions of human perfectibility.

A root-and-branch rethinking of how history has shaped the science of genetics. In 1900, almost no one had heard of Gregor Mendel. Ten years later, he was famous as the father of a new science of heredity—genetics. Even today, Mendelian ideas serve as a standard point of entry for learning about genes. The message students receive is plain: the twenty-first century owes an enlightened understanding of how biological inheritance really works to the persistence of an intellectual inheritance that traces back to Mendel’s garden. Disputed Inheritance turns that message on its head. As Gregory Radick shows, Mendelian ideas became foundational not because they match reality—little in nature behaves like Mendel’s peas—but because, in England in the early years of the twentieth century, a ferocious debate ended as it did. On one side was the Cambridge biologist William Bateson, who, in Mendel’s name, wanted biology and society reorganized around the recognition that heredity is destiny. On the other side was the Oxford biologist W. F. R. Weldon, who, admiring Mendel's discoveries in a limited way, thought Bateson's "Mendelism" represented a backward step, since it pushed growing knowledge of the modifying role of environments, internal and external, to the margins. Weldon's untimely death in 1906, before he could finish a book setting out his alternative vision, is, Radick suggests, what sealed the Mendelian victory. Bringing together extensive archival research with searching analyses of the nature of science and history, Disputed Inheritance challenges the way we think about genetics and its possibilities, past, present, and future.

The essays in this collection examine how human heredity was understood between the end of the First World War and the early 1970s. The contributors explore the interaction of science, medicine and society in determining how heredity was viewed across the world during the politically turbulent years of the twentieth century.