Given the powerful and forthright title of Andrew Dickson White's classic study, it is best to make clear his own sense of the whole as given in the original 1896 edition: "My conviction is that science, though it has evidently conquered dogmatic theology based on biblical texts and ancient modes of thought, will go hand in hand with religion, and that although theological control will continue to diminish, religion as seen in the recognition of a 'power in the universe, not ourselves, which makes for righteousness' and in the love of God and of our neighbor, will steadily grow stronger and stronger, not only in the American institutions of learning, but in the world at large." White began to assemble his magnum opus, a two volume work first published in 1896 as A History of the Warfare of Science with Theology in Christendom. In correspondence he wrote that he intended the work to stake out a position between such religious orthodoxy as John Henry Newman's on one side and such secular scoffing as Robert Ingersoll's on the other. Historian Paul Carter declared that this book did as much as any other published work "toward routing orthodoxy in the name of science." Insofar as science and religion came to be widely viewed as enemies, with science holding the moral high ground, White inadvertently, became one of the most effective and influential advocates for unbelief.

The battle between science and religion in American popular life is as old as America itself. By the late 19th century, it had reached a fever pitch, culminating in the two-volume 1896 work A History of the Warfare of Science with Theology in Christendom. The result of thirty years of research by historian and educator ANDREW DICKSON WHITE (1832-1918), a founder of Cornell University, this is White's attack on intellectually stifling religious dogma and his explication of the "conflict thesis" of outright warfare between science and religion. While scholars today generally see the situation as more nuanced, the conflict thesis remains a popular metaphor in the mind of the general public, and White's work continues to speak to us today. H.L. Mencken called this "one of the noblest monuments of American scholarship," and it will fascinate anyone who is troubled by the ongoing influence by religious authorities into secular science. In Volume II, White looks at the shift "from miracles to medicine," "from demonic possession to insanity," and other modern transformations of humanity's understanding of the world and ourselves.