Acute organ damage and the ensuing multiple organ failure are the result of a pathophysiological process involving various cytokines. Once activated, these proteins cannot be eliminated even when the kidneys function at their maximum capacity. To counteract this mechanism, researchers in Japan have developed an innovative concept employing blood purification to remove the overwhelming cytokines. This book describes the use of hemodiafiltration to inhibit the cytokine storms which cause serious organ damage in patients with septic shock. Moreover, the technical construction of the blood purification system, which includes various machines, devices, membranes, fluids, etc., is explained in detail. Finally, leading experts discuss the concept of continuous renal replacement therapy as the standard care in critically ill patients with severe acute kidney injury. Describing the current state of acute blood purification, this publication provides new impulses and opens new avenues in the treatment of acute organ damage.

In the last twenty years, critical care medicine has been established as a specialty with its own therapies and procedures, with significant implications for clinical nephrology regarding severe acute renal failure. This typically multi-factorial condition is today predominantly seen in intensive care units. The complex knowledge and skills necessary to handle it have resulted in a field called Critical Care Nephrology, where nephrologist and intensivist either work side by side or have formally acquired expertise and training in both specialties. Extracorporeal renal replacement therapies, although originally used to treat end-stage renal disease patients, rapidly gained importance for acute patients. This has had far-reaching implications for the initiation and possible role of blood purification in the management of critically ill patients, widening the scope of interaction between the nephrologist and the intensivist.Experts in the field have contributed to the present book, providing a comprehensive review of the different blood purification techniques relevant in the intensive care unit in the case of multiple organ failure. The resulting mix of established knowledge and recent results from both clinical trials and basic research constitutes a valuable tool for all professionals involved in the care of the critically ill patient.

2023 is the time to collect available knowledge and basic concepts around extracorporeal blood purification in a book that may become the basis for expansion of awareness in the scientific community and a stimulus for new studies and new discoveries by scientists and investigators. We need to answer the question for hemoadsorption that we answered in the last four decades for hemodialysis and CRRT. The pathway towards the new frontier of hemoadsorption starts from this book.

This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

Advances in Patient Care Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Patient Care. The editors have built Advances in Patient Care Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Patient Care in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Patient Care Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The number of dialysis patients, and their ages, continues to increase globally. This creates major issues such as rising medical costs in an aging population, how to best manage end-of-life care, and how to train the various practitioners involved in dialysis care. After the US and China, Japan occupies 3rd place with regard to the number of dialysis patients and is also widely regarded as a world leader in dialysis. This book contains selected articles – organized into 4 chapters - that discuss recent advances in dialysis therapy in Japan. Chapter 1 presents insights into causes, risk factors, disease associations, and possible implications for management of dialysis patients. Chapter 2 examines recent progress in hemodialysis treatment, and chapter 3 focuses on developments in peritoneal dialysis. The final chapter concentrates on recent advances in apheresis and current trends in practice, among other topics. This book is aimed at nephrologists, physicians, urologists, nurses, clinical engineers, pharmacists, and nutritionists. It is a significant contribution to furthering the progress of dialysis therapy worldwide.

Advances in Bloodstream Infection Research and Treatment / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bloodstream Infection in a concise format. The editors have built Advances in Bloodstream Infection Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bloodstream Infection in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bloodstream Infection Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Having examined the new, exciting information about the role of the intestine in the utilization of proteins and their products of digestion, the focus turns to the consequences that catabolic stress and immunologic stimulation have on the qualitative and quantitative aspects of the protein/amino acid metabolism. These aspects are considered with relation to the support of body protein and amino acid homeostasis and requirements in patients with injury, severe infection, gastrointestinal malfunction, cancers and renal disease. Finally, as there is clearly a knowledge gap in this area of clinical/enteral nutrition, the opportunities for future research are highlighted. Written by leading nutritional scientists and clinical investigators, this publication will help practitioners as well as clinical and basic scientists to understand the opportunities enteral nutrition offers in the clinical management of patients.

"This 2nd edition of Critical care nephrology continues to provide comprehensive coverage of the latest advances in critical care procedures for the adult or pediatric patient with renal diseases or disorders. It presents a common language and standardized guidelines to help multi-disciplinary physicians caring for the critically ill communicate more effectively. "--BOOK JACKET.