In this issue of Medical Clinics of North America, guest editors Drs. Heather Toth, Robert Kliegman, and Brett Bordini brings their considerable expertise to the topic of Adolescent Undiagnosed and Rare Diseases. Top experts address diagnostic dilemmas, disease mimics, unusual manifestations of common diseases, and rare disorders presenting as more common diseases in adolescents. Contains 15 relevant, practice-oriented topics including syndromes with severe acne; common variable immunodeficiency (CVID); overlapping pain syndrome; late onset congenital hypoventilation syndrome (LOCH); adolescent onset of muscle weakness; and more. Provides in-depth clinical reviews on adolescent undiagnosed and rare diseases, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editors Drs. Geno Merli and Raghu Kolluri bring their considerable expertise to the topic of Vascular Medicine. Top experts in the field provide evidence-based recommendations on vascular issues and diseases for those in primary care, non-vascular medicine specialists, and nurse practitioners, including articles on atherosclerotic disease, peripheral artery disease, lower extremity vascular ulcers, vasculitis, vascular imaging for the primary care provider, and more. - Contains 12 practice-oriented topics including unprovoked venous thromboembolism: the search for a cause; approach to the patient with non-cardiac leg swelling; cold hands or feet: is it Raynaud's or not?; varicose veins: approaching assessment and management; and more. - Provides in-depth clinical reviews of vascular medicine, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editor Dr. Susan Tuddenham brings her considerable expertise to the topic of Sexually Transmitted Infections. STIs are on the rise in the United States, and concerns for developing drug resistance and new and emerging infections may complicate management. In this issue, top experts in the field provide updates on some of the most important issues in STI diagnosis and management, highlighting new information and practical approaches relevant to primary care practice. - Contains 12 relevant, practice-oriented topics including taking a sexual history: best practices; herpes simplex virus: a practical guide to diagnosis, management, and patient counselling for the primary care clinician; update on monkeypox; sexual health and the transgender patient; and more. - Provides in-depth clinical reviews on sexually transmitted infections, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editors Drs. Alexander Fanaroff and John W. Hirschfeld, Jr., bring their considerable expertise to the topic of Patient Management with Stable Ischemic Heart Disease. Top experts provide insights into newer diagnostic modalities for patients presenting with symptoms of stable ischemic heart disease, review the pillars of medical management as well as emerging cardiometabolic therapies, provide updates on the role of revascularization, and reveal gender, racial, ethnic, and socioeconomic disparities in the presentation and management of stable ischemic heart disease. Contains 13 relevant, practice-oriented topics including optimal medical therapy for stable ischemic heart disease in 2024: focus on antithrombotic therapy; antiplatelet therapy for patients that have undergone revascularization within the past year: which agents and for how long; ischemic heart disease in women: focus on SCAD and MINOCA; and more. Provides in-depth clinical reviews on patient management with stable ischemic heart disease, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editor Dr. Marie Krousel-Wood brings her considerable expertise to the topic of Current Challenges and New Directions in Preventive Medicine. Top experts in the field provide evidence-based recommendations and strategies for common preventative medicine topics, including screening and vaccinations. - Contains 13 relevant, practice-oriented topics including vaccine preventable diseases and vaccine hesitancy; substance use/opioid use disorder and clinical care; obesity-implementing evidence: strategies in clinical practice; healthcare providers and staff coping and burnout in the era of COVID-19; lifestyle medicine; and more. - Provides in-depth clinical reviews on preventive medicine, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Medical Clinics of North America, guest editors Dr. Jeffrey Turner and Ursula Brewster bring their considerable expertise to the topic of An Update in Nephrology. Top experts in the field provide timely updates in CKD, kidney disease, kidney health, renal replacement therapy, and treatments. Contains 12 practice-oriented topics including diagnosis of CKD and assessing eGFR; diabetic nephropathy; pregnancy in CKD: AKI in pregnant women and management of CKD in the pregnant patient; onco-nephrology; and more. Provides in-depth clinical reviews on nephrology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Critical Care Clinics, guest editors Drs. Robert M. Kliegman and Brett J. Bordini bring their considerable expertise to the topic of Undiagnosed and Rare Diseases in Critical Care. Top experts in the field cover key topics such as critical genetic arrhythmia disorders, uncommon causes of rhabdomyolysis, status epilepsy syndromes, autoimmune encephalitis, rapid-onset paralysis and weakness, and more. - Contains 17 relevant, practice-oriented topics including understanding cognitive diagnostic errors in the ICU; rapid WES/WGS in the ICU; diagnostic time-outs to improve diagnosis; when "sepsis is not sepsis: MAS, HLH, malignancies and other sepsis mimics; all that wheezes is not asthma or bronchiolitis; and more. - Provides in-depth clinical reviews on undiagnosed and rare diseases in critical care, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

In this issue of Infectious Disease Clinics of North America, guest editor Dr. Jeanne Marrazzo brings her considerable expertise to the topic of Sexually Transmitted Infections. The CDC approximates that 20% of Americans have experienced a sexually transmitted infection (STI), and the World Health Organization has estimated that over 340 million people live with STIs worldwide every year. In this issue, top experts provide important updates in this area, with goals to provide the relevant clinical information to aid physicians in prevention, diagnosis, and management. - Contains 14 practice-oriented topics including syphilis: a modern resurgence; update in management and prevention of chlamydial infections; non-herpes and non-syphilis causes of genital ulcer disease (including monkeypox, LGV, chancroid); diagnostic advances in sexually transmitted infections; immunizations for sexually transmitted infections; and more. - Provides in-depth clinical reviews on sexually transmitted infections, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Surgical Oncology Clinics, guest edited by Dr. Roshni Dasgupta, is devoted to Pediatric Cancer. Dr. Dasgupta has assembled expert authors to review the following topics: Management of Neuroendocrine Cancer and GIST in Pediatric Patients; Management of Thyroid Tumors in Pediatric Patients; Management of Liver Tumors in Pediatric Patients; Management of Renal Tumors in Pediatric Patients; Management of Rhabdomyosarcoma in Pediatric Patients; Management of non-Rhabdomyosarcoma Soft Tissues Tumors in Pediatric Patients; Management of Melanoma and Skin Cancer in Pediatric Patients; Management of Lung Metastases in Pediatric Patients; Management of Adrenal Tumors in Pediatric Patients; Minimally Invasive Surgery and New Techniques in Pediatric Cancer Patients; Fertility Considerations and the Pediatric Cancer Patient; Management of Neuroblastoma in Pediatric Patients; Management of Germ Cell Tumors in Pediatric Patients; and more!