The guest editors, Dr. William Huang and Dr. Ezequiel Becher, have assembled a state-of-the art issue devoted to Advanced and Metastatic Renal Cell Carcinoma (RCC). They have secured expert authors to contribute clinical reviews on the important topics involving treating and managing patients with RCC. Specific articles are devoted to the following topics: Imaging for Metastatic RCC; Adjuvant Therapy for Localized High Risk RCC; Current Standards for Therapeutic Sequencing for Advanced RCC; Role of Lymphadenectomy in patients with advanced RCC; Cytoreductive Nephrectomy in the Era of TKI/IO - Who, When and Why; Minimally Invasive Surgery for Patients with Locally Advanced and Metastatic Disease RCC; Evolving Role of Urologists in the Management of Advanced RCC; Neoadjuvant Therapy for Locally Advanced RCC; Epidemiology and Risk Assessment/Biomarkers for Patients with Advanced RCC; Radiation Therapy for Patients with Metastatic RCC; Evolving Role of Metastatectomy for Patients with Metastatic RCC; and Management of Non-Clear Cell Metastatic RCC. Readers will come away with the information they need to treat and manage patients and to improve outcomes.

This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology. Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery. Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation.

The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.

In this issue of Urologic Clinics of North America, guest editors Drs. Michael L. Blute and Steven L. Chang bring their considerable expertise to the topic of Renal Cancer: Old and New Paradigms. Recent significant advances in the management of renal cancer have expanded beyond simply eliminating disease to preserving and optimizing quality of life. In this issue, top experts highlight historical perspectives as well as current status and future treatments of renal cancer. - Contains 13 practice-oriented topics on biomarkers for the detection and surveillance of renal cancer; the changing role of renal mass biopsy; renal cysts: an oncological conundrum; the surgical management of renal cancer with inferior vena caval thrombus; integrating surgery in the multidisciplinary care of advanced renal cancer; and more. - Provides in-depth clinical reviews on renal cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Urologic Clinics of North America, guest editor Dr. Craig V. Comiter brings his considerable expertise to the topic of Urologic Pharmacology. Medical therapies for benign prostatic hyperplasia, erectile dysfunction, hypogonadism, overactive bladder, and prostate cancer are widely available, and a basic understanding of the pharmacology of existing treatment options are necessary to avoid complications and maximize efficacy associated with patient outcomes. In this issue, top experts in the field provide current clinical information to help urologists effectively and quickly treat patients. - Contains 14 relevant, practice-oriented topics including medical treatment for benign prostatic hyperplasia, medical treatment for urinary tract infections, nutraceuticals and phytotherapy in men's health, hormonal therapy for prostate cancer, medical treatment of female sexual dysfunction, and more. - Provides in-depth clinical reviews on urologic pharmacology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Urologic Clinics of North America, guest editor Dr. Adam Feldman brings his considerable expertise to the topic of Biomarkers in Urology. The use of biomarkers in clinical practice can range from screening, to refined detection in an at-risk population, to risk stratification following diagnosis, to prognostication following therapy. A better understanding of tumor biology and genetic heterogeneity will lead clinicians to adopt clinical paradigms that utilize sequences of biomarker assessments. In this issue, key experts help you remain at the forefront of the care of urologic malignancies by providing a timely update on emerging biomarkers in urology. - Contains 15 practice-oriented topics including biomarkers in pediatric urology; unleashing the urinary microbiome in benign urologic disease; biomarkers for detection and assessment of clinically significant prostate cancer; biomarkers in testicular cancer: classic tumor markers and beyond; and more. - Provides in-depth clinical reviews on biomarkers in urology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Together with Consulting Editor Dr. Samir Taneja, Dr. Badrinath Konety has put together a comprehensive issue that addresses the latest clinical updates in Male Infertility. Expert authors have contributed clinical review articles on the following topics: Cutting edge evaluation in male infertility; Optimal endocrine evaluation and treatment; Sperm extraction in obstructive azoospermia: What's next; FNA vs. microTESE; ROSI (round spermatid injection); Reproductive Urology in the context of an IVF practice; Care delivery in male infertility; Qualitative research in male infertility; Male Infertility & Somatic Health; DNA fragmentation: Does testicular sperm make sense; CRISPR & Genetics of Male Infertility after whole genome sequencing; Transgenerational epigenetics: A window into paternal health influences on offspring; Spermatogonial Stem Cell Culture in oncofertility; Personalized medicine for the infertile male; and Male Infertility & The future of IVF. Readers will come away with the clinical information they need to improve outcomes in patients with infertility.

The Guest Editors have secured the top urologists to provide current clinical reviews on the latest advances in the management of small renal masses. Articles are devoted to the following topics: hereditary yndromes; trends in renal surgery; humor anatomic complexity; risk assessment; renal biopsy; active surveillance; ablation; surgical techniques; renal ischemia; lymph node dissection; complications; neoadjuvant targeted therapy for renal surgery; salvage surgery; and post-operative surveillance. Readers will come away with a succinct overview of the most clinically relevant articles and be able to immediately implement the clinical information in their practice.

With guidance from Consulting Editor, Dr. Kevin Loughlin, Dr. Deepak Kapoor has created a state-of-the-art issue devoted to the future of the urologist's clinical practice. Expert authors have contributed clinical review articles on the following topics: Workforce Issues in Urology; Development of Physician Leaders; Physician Burnout; Telemedicine; Understanding the Millenial Physician; The role of APPs in Urology; The impact of private equity transaction on urology; The growth of integrated care models in urology; Current and Future Status of Merit-Based Incentive Payment Systems; Advocacy and Health Policy; How to Subspecialize in Large Group Practices; Drug Prices: Strategies to Help Your Patients Manage the High Cost of Drugs; Operationalizing Clinical Research. Urologists will come away with the information they need to improve their expertise in their urologic practices and to improve patient outcomes.

Under the direction of New Consulting Editor, Dr. Kevin Loughlin, Guest Editors Drs. Jim C. Hu and Jonathan Shoag have put together a state-of-the-art monograph on robotics in urologic surgery. Not only do expert authors present current status and advances in this field, but they also look at what the future of robotic urologic surgery will mean for urologists and patients. Clinical review articles are devoted to the following topics: Robotic Ureteral Reconstruction; Robotic Prostatectomy: Technical Modifications that Improve Outcomes; Robotic Radical Cystectomy; Robotic Urology Training; Robotic Prostatectomy Quality Improvements; Robotic Lower Urinary Tract Reconstruction; Incorporating AI into GU Endoscopy; Competing Robotic Systems: A Preview; Robotic Intracorporeal Diversion; Robotic Reconstruction in Pediatric Urology; Robotic Partial Nephrectomy: Update on Techniques; Robotics in Male Infertility; Transperineal Biopsy; Robotic-Assisted Surgery for Upper-Tract TCC; and Retzius-Sparing Robotic Prostatectomy. Urologists will come away with the information they need to stay on top of advances in the area of robotic surgery.