As we know diabetes mellitus is the most common metabolic endocrine disorder. According to the WHO and American Diabetes Mellitus, diabetes mellitus is the 3rd leading cause of death if we were to include all secondary complications. However without including secondary complications, it is 7th place in mortality and morbidity. The point to be considered in the case of diabetes mellitus is the secondary complications caused in this condition. Almost all organs affected by diabetes and results in a potentially worse condition. The major secondary complications are neuropathy, nephropathy, retinopathy, and diabetes foot microvascular and macrovascular complications. The long term complications grow slowly in the case of diabetes. As the time living with diabetes becomes longer, controlled glucose levels will be more difficult to achieve, meaning there there will be more long term complications. The aim of the current Research Topic on the secondary complications of diabetes and their management is to publish good quality research articles as well as reviews, which should address the management of diabetes, abnormalities of secondary complications and other disease involved in diabetes. Potential Topics includes but not restricted to: • Secondary complications of diabetes mellitus • Microvascular and macrovascular complications • The role of oxidative stress in the diabetes burden • New insights in glycemic control • New strategies/ approaches to manage secondary complications such as Stearoyl CoA dismutase, Acetyl CoA Carboxylase, Adiponectin/ Adipocyte complement-related protein 30, Hormone Sensitive Lipase (HSL) Inhibitors • Recent development in the therapeutic approaches for glucose management such as Protein tyrosine phosphatase-1B (PTP1B) inhibitors, Glycogen synthase kinase-3 (GSK3) inhibitors, β3- Adrenergic receptor agonist, Retinoid X receptor, PPARα agonist, AMP activated protein kinase • Development of new target as a target for antihyperglycemic drug designing

This book is intended to provide up-to-date and emerging information in the field of diabetes mellitus with a focus on preventive, predictive and personalized medicine.

Yamada’s Textbook of Gastroenterology has for 20 years been the most comprehensive gastroenterology reference book, combining an encyclopaedic basic science approach to GI and liver disease with the latest clinical thinking, especially in diagnostic and therapeutic developments. It is universally respected across the globe. The original outstanding editorial team was led by Tadataka Yamada, MD, one of the world's leading figures in GI research. As in previous editions, the new textbook reflects the collective efforts of the editors and a hugely impressive team of contributors, who are each experts in their specific areas. Now with another world leader in gastroenterology as Editor-in-Chief, Daniel K. Podolsky MD, President and Professor of Internal Medicine at the University of Texas Southwestern Medical Center, together with a stellar group of associate editors, the 6th edition of this iconic textbook has been expanded and enhanced in many ways with new content and technology.

This issue of Clinics in Podiatric Medicine and Surgery, edited by Dr. Justin Fleming, will cover a number of essential Advanced Techniques in the Management of Foot and Ankle Surgery. Topics discussed throughout the issue include, but are not limited to: Importance of Stress Examination in Foot and Ankle Injuries, Diagnosis and Management of Subtle Lisfranc Injuries, Surgical Repair of Navicular and Cuboid Fractures, Treatment of Talus Fractures, Role for Primary Repair of the Deltoid Ligament Complex in Ankle Fractures, Tibia Plafond Fracture Repair, and Arthroscopic Assisted Open Reduction Internal Fixation, among others.

Diagnosis and Treatment in Internal Medicine equips trainee doctors with the essential skills and core knowledge to establish a diagnosis reliably and quickly, before outlining the management of the clinical condition diagnosed. Organised into three sections, the first provides a vital overview, whilst the second focuses on common presentations and diagnoses. Uniquely, this new book shows readers how to turn symptoms into a list of diagnoses ordered by probability - a differential diagnosis. Experienced consultants who teach trainees every day demonstrate how to derive an ordered differential diagnosis, how to narrow this down to a single diagnosis and if not, how to live with diagnostic uncertainty. The final section provides a comprehensive account of the management of system-based syndromes and diseases. Highly-structured chapters emphasize how common conditions present, how to approach a diagnosis, and how to estimate prognosis, treatment and its effectiveness. An onus is placed on the development of crucial diagnostic skills and the ability to devise evidence-based management plans quickly and accurately, making this an ideal text for core medical trainees.

**Selected for Doody's Core Titles® 2024 in Veterinary Medicine** Streamlined for practical, everyday use in the clinic, Small Animal Dermatology: A Color Atlas and Therapeutic Guide, 4th Edition provides concise, thorough information on more than 250 skin diseases affecting small animals. More than 1,400 high-quality images help to ensure accurate diagnoses, with coverage including recognizable clinical signs, top differentials, diagnostic tests, treatment recommendations, and prognosis for each disorder. The differential diagnosis chapter adds clarity to the difficult task busy students and practitioners face every day – identifying what dermatologic condition is causing a dog, cat, or exotic animal to suffer. Chapters list diseases based upon the frequency of their occurrence in the pet population, and detailed procedures include helpful illustrations of key techniques. - Well-organized, concise, yet comprehensive, coverage of over 250 skin diseases in dogs, cats, birds, and exotic pets like rabbits, ferrets, hamsters, guinea pigs, gerbils, chinchillas, turtles, snakes, and lizards allows for quick and easy reference. - Comprehensive drug appendices highlight information about dosage, adverse reactions, indications, and contraindications for antimicrobial, antiseborrheic, and antipruritic shampoo therapy, topical, otic, and systemic therapeutic drugs. - Detailed procedures include helpful illustrations of key techniques. - Thoroughly covers each disorder with recognizable clinical signs, top differentials, diagnostic tests, treatment recommendations, and prognoses. - More than 1,450 vivid, full-color images in atlas format clearly demonstrate clinical appearance of skin lesions to facilitate accurate diagnosis and treatment. - An atlas of before- and after-treatment images provides you with a compelling client communication tool to promote treatment acceptance and compliance. - Emphasizes important information on the continuing emergence of zoonotic skin diseases in each chapter.

Through nine outstanding editions, Rutherford's Vascular Surgery and Endovascular Therapy has been the gold standard text in this fast-changing, complex field. Published in association with the Society for Vascular Surgery, this state-of-the-art reference by Drs. Anton N. Sidawy and Bruce A. Perler is a must-have for vascular surgeons, interventionalists, vascular medicine specialists, and trainees, as well as general surgeons, interventional radiologists, and cardiologists that depend upon "Rutherford’s" in their practice. It offers authoritative guidance from the most respected and innovative global thought leaders and clinical and basic science experts in the diagnosis and treatment of circulatory disease. Incorporates medical, endovascular, and surgical treatment, as well as diagnostic techniques, decision making, and fundamental vascular biology. Features all vascular imaging techniques, offering a non-invasive evaluation of both the morphology and hemodynamics of the vascular system. Provides unparalleled insight from multidisciplinary leaders worldwide, who share their expertise on the most appropriate contemporary and future treatment of circulatory disease. Employs a full-color layout and images so you can view clinical and physical findings and operative techniques more vividly. Includes 40 new chapters incorporating a shorter, more focused format with a summary for each chapter that provides a quick access to key information – ideal for consultation situations as well as daily practice. Some of these chapters are organized in new sections dedicated to open operative exposure and vessel dissection techniques, diabetic foot, Pediatric Vascular Disease, and practice management issues; areas in the specialty that clinicians frequently face but seldom detailed in other vascular texts nor in earlier Rutherford editions. Covers hot topics such as endovascular therapy of aortic arch and thoracoabdominal aortic aneurysm disease, including the evolving management of aortic dissections. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.