This is a large, all-inclusive reference volume of 67 chapters documenting the very latest experimental and clinical advances in perinatal medicine by world-class experts in the field. It covers fetal anomalies, intrauterine growth and parturition, maternal and infant nutrition, the very low birthweight infant, ultrasound for fetal and neonatal assessment, environmental influences on the embryo and fetus, maternal disease and pregnancy outcome, pre- and perinatal diagnosis and management of inherited metabolic diseases, protection of the fetal/infant brain, investigation and treatment and outcome for fetal abnormalities, perinatal nursing care and perinatal transport, perinatal medicine and professional education in Europe, perinatal cardiorespiratory support, ethics and audit and medicolegal aspects of perinatal practice in Europe, prevention of preterm deliveries, fetal and in-fant learning and behavior, biotechnology and perinatal research, surfactant replacement therapy, and matters of special controversy. Includes bibliographic references and index.

The state of health care is reflected by perinatal and neonatal morbidity and mortality as well as by the frequencies of long-term neurologic and developmental disorders. Many factors, some without immediately rec ognizable significance to childbearing and many still unknown, undoubt edly contribute beneficially or adversely to the outcome of pregnancy. Knowledge concerning the impact of such factors on the fetus and sur viving infant is critical. Confounding analyses of pregnancy outcome, especially these past two or three decades, are the effects of newly un dertaken invasive or inactive therapeutic approaches coupled with the advent of high technology. Many innovations have been introduced with out serious efforts to evaluate their impact prospectively and objectively. The consequences of therapeutic misadventures characterized the past; it seems they have been replaced to a degree by some of the complications of applied technology. Examples abound: after overuse of oxygen was recognized to cause retrolental fibroplasia, its restriction led to an in crease in both neonatal death rates and neurologic damage in surviving infants. Administration of vitamin K to prevent neonatal hemorrhagic disease, particularly when given in what we now know as excessive dos age, occasionally resulted in kernicterus. Prophylactic sulfonamide use had a similar end result. More recent is the observation of bronchopul monary dysplasia as a complication of respirator therapy for hyaline membrane disease.

The state of health care is reflected by perinatal and neonatal morbidity and mortality as well as by the frequencies of long-term neurological and developmental disorders. Many factors, some without immediately recognizable significance to childbearing and many still unknown, undoubtedly contribute beneficially or adversely to the outcome of pregnancy. Knowledge concerning the impact of such factors on the fetus and surviving infant is critical. Confounding analyses of pregnancy outcome, especially these past 2 or 3 decades, are the effects of newly undertaken invasive or inactive therapeutic approaches coupled with the advent of high technology. Many innovations have been introduced without serious efforts to evaluate their impact prospectively and objectively. The consequences of therapeutic misadventures character ized the past; it seems they have been replaced to a degree by some of the complications of applied technology. Examples abound: after overuse of oxygen was recognized to cause retrolental fibroplasia, its restriction led to an increase in both neonatal death rates and neurologic damage in surviving infants. Administration of vitamin K to prevent neonatal hemorrhagic disease, particularly when given in what we now know as excessive dosage, occasionally resulted in kernicterus. Prophy lactic sulfonamide use had a similar end result. More recent is the observation of bronchopulmonary dysplasia as a complication of re spirator therapy for hyaline membrane disease. The decade of the eighties opened with the all-time highest rate of cesarean section in the United States.

This volume is based on presentations at the fifth course on perinatal medicine held in the International School of Medical Sciences at the Ettore Majorana Centre for Scientific Culture in Erice, Sicily, in March 1996. It has had a prolonged gestation, but the presentations have been updated and thus the book will benefit perinatologists internationally.The introductory lecture, by philosopher Donald Evans, is of great interest, discussing the issues which all those involved in reproductive medicine, in its widest sense, are dealing with all the time but seldom think about or put in context. Subsequent papers deal with understanding the development and management of the fetus and newborn along lines which represent real progress in perinatal medicine. The epilogue, based on a seminar, will be a help to all those Europeans and others struggling to present their work in English language journals and books.

Strategies for improving material and perinatal health have been pursued by many institutions and workers worldwide, and this volume brings together many of their significant research findings which have an important bearing on these issues.

Perinatal Medicine: Clinical and Biochemical Aspects of the Evaluation, Diagnosis and Management of the Fetus and Newborn is a collection of papers the details the advances in various areas of perinatal medicine. The materials in the title emphasizes on tackling the clinical and biomedical aspects of perinatal medicine. The coverage of the text includes the endocrine tests in the assessment of pregnancy; role of amniocentesis in elective cesarean section; and pharmacological prevention of premature delivery. The selection also covers the management of diabetes in pregnancy; nutritional management of low birth weight and premature infants; and the immunologic content of human breast milk. The book will be of great use to students, researchers, and practitioners of perinatal medicine. Other health professionals, such as nurses and midwives will also benefit from the text.

**Selected for Doody's Core Titles® 2024 in Pediatrics**A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant provides trusted, time-tested guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. The fully revised 12th Edition is an ideal resource for every stage of practice and remains the most comprehensive, multidisciplinary text in the field. Drs. Richard J. Martin and Avroy A. Fanaroff from Rainbow Babies and Children's Hospital bring you up to date with everything from diagnosis and treatment selection through post-treatment strategies and management of complications—all with a dual focus on neonatology and perinatology, and all designed to help you improve the quality of life and long-term outcomes of your patients. - Provides up-to-date, evidence-based content throughout, including state-of-the-art coverage of personalized medicine and genetics. - Contains new chapters on Big Data for the Smallest Patients: What we can learn from neonatal database research; Role of Umbilical Cord Management in Neonatal Resuscitation; Care of Periviable Micropremies: the Japanese perspective; Longer Term Respiratory Outcomes of Prematurity; and Perinatal Palliative Care. - Features extensive updates throughout, including blood and the hematopoietic system; social and economic contributors to neonatal outcome; fetal growth restriction; diagnostic imaging of the neonate; anesthesia in the neonate; postnatal bacterial infections; neonatal management of congenital heart disease; and retinopathy of prematurity. - Includes over 600 detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. - Provides indexing in both volumes that provides quick access to specific guidance. - Offers a global perspective with an expanded number of international contributors. - An ideal resource for clinical practice as well as recommended reading for neonatology board review or maintenance of certification. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.