Advances in Treatment of Bipolar Disorders provides clinicians with a well-written and timely guide to the most recent advances in the treatment of patients with this complex disorder. Staying abreast of new research developments and treatment options presents a daunting challenge, but the editor and coauthors have compiled the most important evidence-based findings from controlled studies and U.S. Food and Drug Administration approved indications, facilitating integration of these findings into clinical practice. This volume strives to provide clinicians with the necessary information to enable them to balance the likelihood of benefit (using “number needed to treat” analyses) versus harm (using “number needed to harm” analyses) in order to provide individualized, state-of-the-art, evidence-based care. The most current research findings are complemented by the authors’ extensive personal clinical experiences, resulting in a volume that reflects the most up-to-date thinking about the diagnosis and management of bipolar disorder. Advances in Treatment of Bipolar Disorders belongs in every mental health clinician’s library.

Despite works published as recently as 2002, the continuing rapid evolution of new medications and adjunctive psychosocial interventions for bipolar disorder has made the concise Advances in Treatment of Bipolar Disorder essential for today's clinicians who want to stay abreast of the latest developments in treating this complex and challenging mental illness. Meticulously referenced with numerous tables and illustrations, Advances in Treatment of Bipolar Disorder offers a very timely and exciting perspective on new ways to treat bipolar disorder. After an overview, six succinct chapters written by experts review recent developments -- emphasizing interventions supported by controlled studies -- in the following areas: Advances in treatment of patients with acute mania: discussing newer antipsychotics, which as a class are effective as primary treatments for acute mania, and have emerging potential roles in maintenance treatment, and acute bipolar depression; and anticonvulsants, some of which are effective for as primary treatments for acute mania or maintenance, and others of which although not primary treatments for bipolar disorders may provide benefits as adjuncts for comorbid conditions. New developments in the treatment of acute bipolar depression: describing therapeutic options beyond mood stabilizers and highlighting that adjunctive use of antidepressants requires additional adequately powered controlled studies to support this common approach. Techniques in the maintenance treatment of patients with bipolar disorder: including both medications and adjunctive psychosocial therapies, which together can help clinicians manage medication adverse effects and maintain the therapeutic alliance, treatment adherence, and involvement of significant others to enhance outcomes. Innovations in the treatment of rapid-cycling bipolar disorder: although no treatment has received FDA approval for the management of this challenging presentation, results of controlled trials are beginning to provide clinically relevant insights in to the treatment of patients with rapid cycling, offering hope for more effective future therapies. The treatment of children and adolescents with bipolar disorder: no treatment has FDA approval for the treatment of pediatric patients with bipolar disorder and controlled data are limited, yet recent research is beginning to yield important new information about the diagnosis and management of children and adolescents with this illness or its putative prodromes. Phenomenology and management of bipolar disorder in women: introducing important new information to enhance clinicians' understanding of the importance of accounting for gender differences and reproductive health in the treatment of women with bipolar disorder. Advances in Treatment of Bipolar Disorder helps clinicians to better understand the utility of both older medications and important new treatment options as it highlights the need for additional research to ensure further progress in overcoming the challenges of caring for patients with bipolar disorder.

Clinicians searching for evidence-based quantitative assessments on which to base diagnosis and treatment of patients with bipolar disorder need look no further. Advances in Treatment of Bipolar Disorders analyzes the benefits and harms for both older and more recently developed treatments, and places these analyses in the context of the authors' many years of clinical experience. The result is a book that is both quantitatively sound and qualitatively rich, and one that will help clinicians understand the latest research and integrate it into their practices with confidence. In addition to comprehensive coverage of the most important recent advances, the book addresses advances in more specific areas, including the treatment of particular populations such as women, children, and older adults. In addition, the book covers many critically important topics and boasts an abundance of helpful features: Evidence-based quantitative assessments of benefits use "numbers needed to treat" for therapeutic effects and "numbers needed to harm" for side effects, ensuring that the quality of data supporting interventions meets a rigorous standard. The book's information is based not only on controlled trials and FDA approvals but also on almost two decades of clinical research and clinical treatment experience by clinicians at Stanford University. Plentiful figures and summary tables are provided to summarize the content and make it easy-to-grasp and clinician-friendly. In addition to coverage of acute bipolar depression and acute manic and mixed episodes, the book provides chapters on the preventive treatment of bipolar disorder and the pharmacology of mood-stabilizing and second-generation antipsychotic medications. Bipolar disorders are challenging and complex mental illnesses, and clinicians need all the help they can get in managing the effects of these illness on their patients' lives. Advances in Treatment of Bipolar Disorders aims to provide everything clinicians need to know to update their knowledge of this rapidly evolving field and ensure an evidence-based standard of care for this patient population.

This readable guide to the assessment and management of patients with bipolar disorder can help physicians keep abreast of dramatic and rapid advances of recent years and integrate them into their practice. Handbook of Diagnosis and Treatment of Bipolar Disorders emphasizes recent controlled studies and FDA-approved indications and translates these data into the real world of clinical practice. The contributions of the eleven chapter authors from Stanford University reflect more than a decade of clinical research and treatment undertaken at that institution, including advances in diagnosis and interventions supported by controlled studies. They provide crucial information regarding diagnosis, pharmacotherapy, psychotherapy, and treatment of patients from special populations -- such as children, women, and older adults -- and patients with particular challenging illness course such as rapid cycling. This is the first book to provide quantitative assessment of potential benefit (number needed to treat) and risk (number needed to harm) for all approved treatments for bipolar disorder, providing clinicians with information needed to balance benefits and risks in order to render individualized state-of-the-art, evidence-based care. It describes all FDA-approved indications -- reviewing efficacy, safety, tolerability, pharmacokinetics, illness phase-specific dosing, and drug interactions. A chapter on multiphase treatment strategy explains crucial illness transition points and describes how these have been integrated with knowledge of illness phase in mood disorders. The book then demonstrates the relevance of this approach to therapeutics by providing: An overview of pharmacotherapy that covers the emergence of evidence-based pharmacotherapy and number-needed-to-treat and -harm analyses. Guidelines to managing acute manic and mixed episodes that include evidence-based assessments of lithium, divalproex, carbamazepine, and second-generation antipsychotics. Coverage of acute major depressive episodes in bipolar disorders that outlines four tiers of treatment for this most pervasive illness phase with the fewest approved treatments. Discussion of the longer-term management of bipolar disorders, including reviews of controlled trials of recently approved pharmacotherapies such as lamotrigine, olanzapine, aripiprazole, and adjunctive quetiapine. A review of the use of mood stabilizers and second-generation antipsychotics, often in combinations, as well as the controversial role of adjunctive antidepressants in treating patients with rapid-cycling bipolar disorders. Description of important advances in evidence-based adjunctive psychotherapeutic interventions in bipolar depression, and bipolar maintenance treatment. Comprehensive in scope, yet readily accessible for application to clinical practice, the book includes summary tables, quick-reference lists of clinical pearls, and case studies to make its content more relevant. Handbook of Diagnosis and Treatment of Bipolar Disorders is the ideal source for integrating recent research into everyday practice.

Bipolar disorder is a chronic and debilitating mental illness affecting a significant proportion of the world's population. It is associated with significant impairments in health-related quality of life and psychosocial functioning, and has significant illness-related morbidity and heightened mortality rates due to medical comorbidities and suicide. The management of this disorder requires a complex combination of pharmacological and psychosocial interventions which can be challenging for clinicians. Written by world experts in the field of bipolar disorder, The Treatment of Bipolar Disorder: Integrative Clinical Strategies and Future Directions provides readers with a concise and comprehensive guide to the integrative management of bipolar disorder. This resource contains 31 chapters on the various management choices available, from both established and novel treatment areas, such as psychoeducation, psychotherapeutic interventions, neuromodulatory approaches and novel therapeutic targets. The complexity and diversity of the management choices available makes this a continually evolving field and necessitates forward thinking. By both discussing the current management of bipolar disorder, and the future developments available, this resource provides all clinicians working with patients with bipolar disorder an up-to-date and reflective guide to its management and what the future holds.

Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this

Here is a comprehensive overview of the drugs that act on the central and peripheral nervous systems. This volume thoroughly describes the diseases associated with the nervous system and the drugs used for their treatment while also looking at the current status of these drugs and their future potential and challenges. Divided into three sections, the book first focuses on the drugs that affect the functions of the autonomic nervous system to produce therapeutic effects. These drugs may act presynaptically by manipulating the genesis, storage, and secretion, and by blocking the action of neurotransmitters. Some drugs may trigger or impede postsynaptic receptors. Section 2 focuses on drugs that affect the central nervous system, including antianxiety drugs, sedative and hypnotic drugs, antidepressant drugs, antipsychotic drugs, antiepileptic drugs, and many more. It covers the pharmacological management of various diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and others. The last section offers explanations of neurochemical interactions with the aim to develop drugs that have beneficial effects on neurochemical imbalances. This section demonstrates models to assess the transport of drugs across the blood-brain barrier and nanomedicine to treat brain disorders. This rich compilation provides thorough and extensive research updates on the important advances in neuropharmacological drugs and drug therapy from experienced and eminent academicians, researchers, and scientists from throughout the world.

A guide to treating psychosis that provides information on drug options and side-effects in order to allow for weighing treatment options knowledgably The Maudsley Guidelines on Advanced Prescribing in Psychosis offers a resource that puts the focus on the need to treat the individual needs of a patient. The authors – noted experts on the topic – offer an alternative to the one-size-fits-all treatment of psychosis and shows how to build psychiatrist and patient relationships that will lead to effective individual treatment plans. The book provides up-to-date data and information about commonly used anti-psychotic drugs and drugs used in bipolar disorder. The text weighs both the upsides and downsides of each pharmaceutical presented, and helps prescribers and patients weigh the costs and benefits of various options to reach an appropriate treatment plan. The authors highlight the treatment at a population level and the systems in which individual treatments take places. This important resource: Facilitates the tailoring of an appropriate treatment plan for clients manifesting signs of psychosis Offers a comparative strategy that helps gauge the suitability of one treatment plan over another Provides at-hand data and information about commonly used anti-psychotic drugs Includes an understanding of the origins and side-effects of each drug presented The Maudsley Guidelines on Advanced Prescribing in Psychosis offers psychiatrists and other mental health practitioners an essential guide for treating psychosis on an individualized level.

In the realm of healthcare, the search for effective treatments and therapies is a constant journey. Turner Syndrome, a complex genetic condition affecting numerous aspects of an individual's life, has led us to explore unconventional avenues in pursuit of holistic healing. This book delves into a groundbreaking approach that combines Apometry, Neuro-Linguistic Programming (NLP), regression, and hypnosis to provide advanced treatment possibilities for individuals with Turner Syndrome. Turner Syndrome, characterized by the absence or partial absence of one X chromosome in females, brings forth a myriad of challenges that touch not only the physical but also the emotional and psychological dimensions of those it affects. As medical science continues to evolve, so do the methods we employ to alleviate the burdens imposed by genetic conditions. The methodologies outlined within these pages are a testament to the fusion of ancient wisdom and modern insights, offering new avenues of hope and healing. The concept of Apometry, a lesser-known healing modality, forms the cornerstone of this book. Apometry invites us to explore the ethereal realm, harnessing energies that resonate beyond the physical plane. By synergizing Apometry with NLP, regression, and hypnosis, we embark on a journey that traverses the boundaries between science and spirituality, seeking to address the multifaceted nature of Turner Syndrome. Each chapter of this book is a window into a realm of possibilities, inviting you to explore the techniques, practices, and insights that weave the fabric of this novel approach to healing. From the intricacies of performing an Apometry session to the profound impact of spiritual healing, this book is designed to equip both practitioners and seekers with tools that can facilitate transformation and well-being. It's important to acknowledge that while the methodologies discussed herein hold immense promise, they also provoke curiosity and skepticism. The intention is not to replace conventional medical care, but to supplement it with alternative perspectives that may lead to a more comprehensive understanding of health and healing. As you embark on this journey through the pages of "Advanced Treatment for Turner Syndrome: Apometry, NLP, Regression, and Hypnosis," I encourage you to approach these concepts with an open heart and an inquisitive mind. The synergy of ancient practices, modern therapies, and cutting-edge research has the potential to unveil paths that were previously unexplored. The individuals living with Turner Syndrome and their families are at the heart of this endeavor, inspiring us to push the boundaries of what is possible in the realm of healing. May this book ignite a spark of curiosity, encouraging dialogue, research, and collaboration in the pursuit of comprehensive well-being for all.

Awarded second place in the 2017 AJN Book of the Year Awards in the Adult Primary Care Category and a 2019 PROSE Award finalist. Get all of the pharmacotherapeutics principles and content you need to become a safe and effective prescriber with Lehne's Pharmacotherapeutics for Advanced Practice Providers. This new text is built on the same solid foundation of clearly explained, up-to-date, and clinically current content as the undergraduate-level Lehne’s Pharmacology for Nursing Care, yet carefully focuses on the specific principles and drug content needed by primary and acute care nurse practitioners, physician assistants, and clinical nurse specialists. Three introductory chapters provide foundational content in the areas of prescriptive authority, rational drug selection, prescription writing, and promoting positive outcomes of drug therapy. Core chapter content centers on the drugs that advanced practitioner prescribers will see most commonly in clinical practice. You’ll also notice a sharp focus on pharmacotherapeutic decision-making along with a number of prescriber-focused pedagogical aids — including Black Box Warnings — to reinforce the most important information and help you make optimal pharmacotherapeutic decisions. Introductory chapters tailored to the specific needs of advanced practice prescribers cover topics such as prescriptive authority, rational drug selection and prescription writing, and promoting positive outcomes of drug therapy. Carefully focused pharmacotherapeutic content reflects the drugs most commonly seen and used by advanced practice prescribers, with emphasis not on the first drug discovered or developed in each class but on the agents most often used today. Primary care drugs are addressed first in each chapter as appropriate, followed by and acute care drugs. UNIQUE! Prescriber-focused pedagogical aids further reinforce the most important information for advanced practice prescribers. Black Box Warnings alert you to special warnings and precautions related to particular drugs. Integrated coverage of Canadian trade names appears throughout the text and is highlighted with a familiar maple-leaf icon. Integrated coverage of interprofessional collaboration addresses the growing global interest in interprofessional collaboration and incorporates opportunities for interprofessional collaborative practice throughout.