Many biological systems and objects are intrinsically fuzzy as their properties and behaviors contain randomness or uncertainty. In addition, it has been shown that exact or optimal methods have significant limitation in many bioinformatics problems. Fuzzy set theory and fuzzy logic are ideal to describe some biological systems/objects and provide good tools for some bioinformatics problems. This book comprehensively addresses several important bioinformatics topics using fuzzy concepts and approaches, including measurement of ontological similarity, protein structure prediction/analysis, and microarray data analysis. It also reviews other bioinformatics applications using fuzzy techniques.

FUZZY LOGIC APPLICATIONS IN COMPUTER SCIENCE AND MATHEMATICSTICS The prime objective of developing this book is to provide meticulous details about the basic and advanced concepts of fuzzy logic and its all-around applications to different fields of mathematics and engineering. The basic steps of fuzzy inference systems starting from the core foundation of the fuzzy concepts are presented in this book. The fuzzy theory is a mathematical concept and, at the same time, it is applied to many versatile engineering fields and research domains related to computer science. The fuzzy system offers some knowledge about uncertainty and is also related to the theory of probability. A fuzzy logic-based model acts as the classifier for many different types of data belonging to several classes. Covered in this book are topics such as the fundamental concepts of mathematics, fuzzy logic concepts, probability and possibility theories, and evolutionary computing to some extent. The combined fields of neural network and fuzzy domain (known as the neuro-fuzzy system) are explained and elaborated. Each chapter has been produced in a very lucid manner, with grading from simple to complex to accommodate the anticipated different audiences. The application-oriented approach is the unique feature of this book. Audience This book will be read and used by a broad audience including applied mathematicians, computer scientists, and industry engineers.

Biological systems are inherently stochastic and uncertain. Thus, research in bioinformatics, biomedical engineering and computational biology has to deal with a large amount of uncertainties. Fuzzy logic has shown to be a powerful tool in capturing different uncertainties in engineering systems. In recent years, fuzzy logic based modeling and analysis approaches are also becoming popular in analyzing biological data and modeling biological systems. Numerous research and application results have been reported that demonstrated the effectiveness of fuzzy logic in solving a wide range of biological problems found in bioinformatics, biomedical engineering, and computational biology. Contributed by leading experts world-wide, this edited book contains 16 chapters presenting representative research results on the application of fuzzy systems to genome sequence assembly, gene expression analysis, promoter analysis, cis-regulation logic analysis and synthesis, reconstruction of genetic and cellular networks, as well as biomedical problems, such as medical image processing, electrocardiogram data classification and anesthesia monitoring and control. This volume is a valuable reference for researchers, practitioners, as well as graduate students working in the field of bioinformatics, biomedical engineering and computational biology.

This title describes the main problems in bioinformatics and explains the fundamental concepts and algorithms of machine learning. Illustrative examples from bioinformatics demonstrate the capabilities of state-of-the-art machine learning techniques and how they can be applied to bioinformatics problems.

A man disappears. The woman who loves him is left scarred and haunted. In her fierce, one-of-a-kind debut, Rebecca Lindenberg tells the story—in verse—of her passionate relationship with Craig Arnold, a much-respected poet who disappeared in 2009 while hiking a volcano in Japan. Lindenberg’s billowing, I-contain-multitudes style lays bare the poet’s sadnesses, joys, and longings in poems that are lyric and narrative, at once plainspoken and musically elaborate. Regarding her role in Arnold’s story, Lindenberg writes with clear-eyed humility and endearing dignity: “The girl with the ink-stained teeth / knows she’s famous / in a tiny, tragic way. / She’s not / daft, after all.” And then later, playfully, of her travels in Italy with the poet, her lover: “The carabinieri / wanted to know if there were bears / in our part of America. Yes, we said, / many bears. Man-eating bears? Yes, of course, / many man-eating bears.” Every poem in this collection bursts with humor, pathos, verve—and an utterly unique, soulful voice. This widely anticipated debut, already selected as a finalist for several prominent book awards, marks the first collection in the newly minted McSweeney’s Poetry Series. MPS is an imprint which seeks to publish a broad range of excellent new poetry collections in exquisitely designed hardcovers—poetry that’s useful and meaningful to anyone in any walk of life.

"The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book." —Dieter Naf, Jackson Laboratory, USA Cancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences. This groundbreaking title provides a comprehensive and up-to-date account of the enormous range of bioinformatics for cancer therapy development from the laboratory to clinical trials. It functions as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the interdisciplinary research community involved.

Issuing in-depth coverage of the principles and applications of bioinformatic analyses of nucleic acid and protein sequences, databases and data mining, discusses dynamic programming algorithms, amino acid exchange matrices and pair-wise sequence alignment tools in extensive detail.

Annotation The book contains the Proceedings of KES 2002, the Sixth Edition of the Knowledge-Based Intelligent Information & Engineering Systems International Conference. The conference papers presented new research results, focusing on three main areas of interest: Generic Intelligent Techniques: This area includes results on basic disciplines underlying knowledge-based and intelligent systems, such as artificial neural networks, machine learning, knowledge-based systems, case-based reasoning, intelligent agents and soft computing. Applications of Intelligent Systems: The second area presents results on vertical applications of intelligent systems, including condition monitoring, fault diagnosis, industrial control, medical systems, image processing, financial & stock market monitoring and prediction, natural language processing and others. Allied Technologies: This area includes novel contributions on intelligent systems' applications to traditional research fields such as digital and computer communications, signal processing, virtual reality, multi-media, web-based technologies, human-computer interfaces and software engineering."