Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.

Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. - Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. - Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. - Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. - Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. - Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. - Discusses today's key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Advanced and Modern Approaches for Drug Delivery explores novel approaches currently used for drug delivery, including the must up-to-date techniques and technology. The approaches discussed allow pharmaceutical scientists to design effective drug delivery systems or devices for the management and treatment of numerous diseases and conditions. Detailed information on a wide variety of subjects, including dendrimers, lipid nanostructures, solid lipid nanoparticles, stimuli-responsive smart systems, self-assembled protein-drug nanoparticles, nanoconjugate formulations, nanofibers, iontophoretic systems, microneedle systems, ultra-sound triggered systems, targeted carrier-based intracellular delivery systems, resealed erythrocyte-based systems, 3 D-printing tool, site-specific monoclonal antibodies, and bio-inspired systems are all comprehensively discussed. With contributions from those in academia and industry, this book is an excellent reference for all those needing to understand drug delivery systems. - Provides thorough insights into the most up-to-date approaches and technologies for drug delivery and therapeutics - Discusses possible future approaches - Includes perspectives from industry and academia

New therapies are currently being developed in the field of skin cancer. In particular, advances in melanoma now represent the frontline of cancer immunotherapy, as immunological findings in the disease have led to the development of highly effective immune-checkpoint inhibitors. However, these immune-checkpoint inhibitors are only effective in a subset of patients, and may not work in other skin cancer types, thus highlighting the need for further innovation in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments.

March 21-22, 2019 , Rome, Italy Key Topics : Cell Therapy,Gene Therapy,Stem Cell Therapies,Cell Culture and Bioprocessing,Viral Gene Therapy,Cell and Gene Therapy for Rare & Common Diseases,Tissue Science & Regenerative Medicine,Molecular Basis of Epigenetics,Bioengineering Therapeutics,Cell Science and Stem Cell Research,Clinical Trials on Cell & Gene Therapy,Nano Therapy,Genetic Engineering,Advanced Gene Therapeutics,Genetics & Genomic Medicine,Ethical Issues in Cell and Gene Therapy,Cell Therapy for Cardiovascular and Neurological Disorders,Regulatory and Safety Aspects of Cell and Gene Therapy,Markets & Future Prospects for Cell & Gene Therapy,Commercialization,

Knowledge concerning oesophageal pathophysiology has until recently lagged far behind that of the pathophysiology of other portions of the gastrointestinal (GI) tract for reasons that still remain unclear. Yet, it is the fact that, at least until the last few decades, interest in the oesophagus was primarily based on pathologic anatomy. Even today, much remains to be learnt on the pathophysiology of oesophageal disease. The recent development of methods of studying both morphology and function of the oesophagus has resulted in a better understanding of normal and abnormal oesophageal patterns with a corresponding improvement in treatment, which is now physiologically, rather than anatomically based. As customary, the World OESO Congresses are planned to provide each time a thorough analysis of a specific topic in oesophageal disease. The 8th World Congress of OESO was devoted to the Foregut: Function and Dysfunction to emphasise the complex interaction between the oesophagus and the other portions of the upper GI tract, either in maintaining physiological function or in triggering oesophageal disease. The choice is a timely one because recent investigations have allowed new insights into the pathophysiology of these complex interactions to be gained. It is indeed becoming clear that there are intriguing pathophysiological abnormalities that account for upper GI symptoms and that more targeted therapy is needed to address the unmet clinical needs. Within this framework, specific sessions were devoted to disorders of secretion, of motility as well as of nutrition with a special emphasis on recent advances. Unlike some of the other publications, this volume does not merely represent the proceedings of an International Congress. With its now established and successful format, it collects the answers to 130 key questions, offered by 110 basic scientists and clinicians the world over, all of whom have personally contributed to the topic, in order to provide a glimpse of what may lie ahead. The easy-to-read format will allow the practising and busy physician to keep up efficiently with advances in diagnosis and therapy in this rapidly evolving field.