In Memoriam of Alfred S. Evans This third edition of Bacterial Infections of Humans is dedicated to Alfred Spring Evans, who died on January 21, 1996, 2Yz years after a diagnosis of cancer. Al was the senior editor of this textbook, which he founded with Harry Feldman in 1982. Al was a clinician, epidemiologist, educator, catalyst for biomedical research, historian, author, speaker, seeker of the truth, sincere friend of students, sports enthusiast, traveler, and truly a man of all seasons. He was a devoted husband to Brigette Klug Evans, father of three children, and grandfather of four. Al was born in Buffalo, New York, on August 21,1917, to Ellen Spring and John H. Evans, M.D., one ofthe United States's first anesthesiologists and an early researcher in the field of oxygen therapy. He received his undergraduate training at the University of Michigan; was awarded an M.D. degree in 1943 from the University of Buffalo; interned in Pittsburgh, Pennsylvania; and performed his medical residency at the Goldwater Hospital in New York City. He was in the United States Army from 1944 to 1946, assigned as a public health officer to a base in Okinawa, Japan. It was there that he met Drs.

PATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references. This detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context. Pathogenesis of Bacterial Infections in Animals, Fifth Edition also contains information on: Themes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era Evolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity Understanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies Subversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity Pathogenesis of Bacterial Infections in Animals, Fifth Edition is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.

This updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.

Bacterial Infections of the Central Nervous System aims to provide information useful to physicians taking care of patients with bacterial infections in the central nervous system (CNS), which can lead to morbidity and mortality. The increased number of patients suffering from this infection has led to the development of vaccines and antibiotics. Comprised of four chapters, the book explains the general approach to patients with bacterial CNS infection. It also discusses various CNS infection concepts and terms. These include the characteristic neuroimaging appearance of specific bacterial infections, the limitations of neuroimaging, the cerebrospinal fluid analysis, the pathogenesis and pathophysiology of bacterial CNS infections, the developments of specific adjunctive strategies, and the principles of antimicrobial therapy. It also includes discussions on various diseases that target the CNS, such as meningitis, focal CNS infections, neurological complications of endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, and CNS diseases caused by selected infectious agents and toxins. This book will serve as a guide for clinical physicians who have patients suffering from bacterial CNS infection. - Valuable insights into the pathophysiological mechanism of bacterial CNS infections - A multidisciplinary reach that provides critical information for neurologists, neurosurgeons, and specialists in infectious disease - Considerable information and emphasis on new diagnostic techniques and laboratory testing

Our gut is colonized by numerous bacteria throughout our life, and the gut epithelium is constantly exposed to foreign microbes and dietary antigens. Thus, the gut epithelium acts as a barrier against microbial invaders and is equipped with various innate defense systems. Resident commensal and foreign invading bacteria interact intimately with the gut epithelium and can impact host cellular and innate immune responses. From the perspective of many pathogenic bacteria, the gut epithelium serves as an infectious foothold and port of entry for disseminate into deeper tissues. In some instances when the intestinal defense activity and host immune system become compromised, even commensal and opportunistic pathogenic bacteria can cross the barrier and initiate local and systematic infectious diseases. Conversely, some highly pathogenic bacteria, such as those highlighted in this book, are able to colonize or invade the intestinal epithelium despite the gut barrier function is intact. Therefore, the relationship between the defensive activity of the intestinal epithelium against microbes and the pathogenesis of infective microbes becomes the basis for maintaining a healthy life. The authors offer an overview of the current topics related to major gastric and enteric pathogens, while highlighting their highly evolved host (human)-adapted infectious processes. Clearly, an in-depth study of bacterial infectious strategies, as well as the host cellular and immune responses, presented in each chapter of this book will provide further insight into the critical roles of the host innate and adaptive immune systems and their importance in determining the severity or completely preventing infectious diseases. Furthermore, under the continuous threat of emerging and re-emerging infectious diseases, the topic of gut-bacteria molecular interactions will provide various clues and ideas for the development of new therapeutic strategies.

Co-published with the Denver Museum of Nature & Science. Thoroughly revised and updated, Mammals of Colorado, Second Edition is a comprehensive reference on the nine orders and 128 species of Colorado's recent native fauna, detailing each species' description, habitat, distribution, population ecology, diet and foraging, predators and parasites, behavior, reproduction and development, and population status. An introductory chapter on Colorado's environments, a discussion of the development of the fauna over geologic time, and a brief history of human knowledge of Coloradan mammals provide ecological and evolutionary context. The most recent records of the state's diverse species, rich illustrations (including detailed maps, skull drawings, and photographs), and an extensive bibliography make this book a must-have reference. Amateur and professional naturalists, students, vertebrate biologists, and ecologists as well as those involved in conservation and wildlife management in Colorado will find value in this comprehensive volume.