This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.

A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers. This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology. - The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention - Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves - Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries) - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.) - Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers - Heavily illustrated with over 100 color figures

Psychology is of interest to academics from many fields, as well as to the thousands of academic and clinical psychologists and general public who can't help but be interested in learning more about why humans think and behave as they do. This award-winning twelve-volume reference covers every aspect of the ever-fascinating discipline of psychology and represents the most current knowledge in the field. This ten-year revision now covers discoveries based in neuroscience, clinical psychology's new interest in evidence-based practice and mindfulness, and new findings in social, developmental, and forensic psychology.

Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood. - Features two new sections on serotonin systems interactions and serotonin in neurological disorders - Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior - Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes - Covers the interactions between serotonin, melatonin and kynurenine pathways

This clinically focused book is designed to help clinicians help older persons maintain that joy. Now divided into 9 comprehensive sections, this edition contains subjects ranging from geriatric assessment to pain management and palliative care.

The field of gerontology has often been criticized for being "data-rich but theory-poor." The editors of this book address this issue by stressing the importance of theory in gerontology. While the previous edition focused on multidisciplinary approaches to aging theory, this new edition provides cross-disciplinary, integrative explanations of aging theory: The contributors of this text have reached beyond traditional disciplinary boundaries to partner with researchers in adjacent fields in studying aging and age-related phenomena. This edition of the Handbook consists of 39 chapters written by 67 internationally recognized experts in the field of aging. It is organized in seven sections, reflecting the major theoretical developments in gerontology over the past 10 years. Special Features: Comprehensive coverage of aging theory, focusing on the biological, psychological, and social aspects of aging A section dedicated to discussing how aging theory informs public policy A concluding chapter summarizing the major themes of aging, and offering predictions about the future of theory development Required reading for graduate students and post doctoral fellows, this textbook represents the current status of theoretical development in the study of aging.

Neurogerontology tells the story of how the aging brain affects all aspects of cognition and physical performance. It comprehensively links the principles and substance of neuroscience with gerontology and psychology. Written largely from a behavioral neuroscience perspective, Neurogerontology explores the functional relationships between the central nervous system and psychological phenomena of aging, including perception, arousal, learning, cognition, and motor behavior. Willot emphasizes healthy aging, but dementia and other pathological conditions are discussed when relevant. This evidence-based approach to the neuroscience of aging makes this a valuable reference for professionals, as well as an informative textbook for students in gerontology courses.

As technology has made imaging of the brain noninvasive and inexpensive, nearly every psychologist in every subfield is using pictures of the brain to show biological connections to feelings and behavior. Handbook of Neuroscience for the Behavioral Sciences, Volume I provides psychologists and other behavioral scientists with a solid foundation in the increasingly critical field of neuroscience. Current and accessible, this volume provides the information they need to understand the new biological bases, research tools, and implications of brain and gene research as it relates to psychology.

Classical conditioning of the nictitating membrane (NM) eyeblink response in rabbits is a useful model system for the study of the neurobiology of learning and memory. This paradigm that is so well described on a biological level has also been applied to studies of normal development over the life span and to instances of abnormal developmental phenomena. Eyeblink conditioning has been studied from molecular and neural network perspectives, and the paradigm is of demonstrated utility in elucidating mechanisms in physiology and pharmacology. This model system provides a behavioral paradigm in animals that has a close analog in human behavior. Perspectives of recent developments in human eyeblink classical conditioning research are presented in the companion volume to this book, Eyeblink Classical Conditioning: Applications in Humans.

Principles of Frontal Lobe Function, Second Edition is an expanded volume, divided into 9 sections representing major research and clinical disciples, including new topics such as social neuroscience. This book will provide clinicians, researchers, and students with the most current information as the mystery of the frontal lobes is unraveled.