Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. - Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide - Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases - Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction

Stroke is a global health problem affecting approximately 15 million people annually in the world and about 700,000 in the United States. It is the third leading cause of death and the most common cause of disability in most developed countries. Acute Ischemic Injury and Repair in the Nervous System is intended to provide the most up-to-date knowledge of the mechanisms of neuronal death and repair after stroke. It is our belief that this volume of the Handbook of Neurochemistry and Molecular Neurobiology provides an excellent review of the tremendous advances of the past decades in the neurochemical and molecular biological aspects of cerebral ischemia. It is hoped that these advances will provide an impetus for basic scientists and clinicians to further their translational research and to promote the insights for development of therapeutic interventions for stroke.

Nitric Oxide in Transplant Rejection and Anti-Tumor Defense represents a unique combination of three interrelated topics that is unavailable in any other single work: The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; Nitric oxide in immune mechanisms of allograft rejection; and The involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.

This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications. ​

Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.

Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke. Available in both print and online formats, this survey of the basic and clinical science of stroke is an essential resource for all involved in advancing knowledge of cerebrovascular disease.

The 53rd National Congress of the Italian Society of Biochemistry and Molecular Biology (SIB), which will be held in Riccione from 23 to 26 September, is characterised by the elevated scientific level and interdisciplinary interest of the numerous sessions in which it is organised. The Scientific Programme comprises three joint Symposia of the SIB and the Chemistry of Biological Systems section of the Italian Chemistry Society (SCI) on Molecular Systems Biology, Chemistry of Nucleic Acids, Protein and Drug Structure, and Environmental Biotechnology. These Symposia address groundbreaking arguments, making the joint interest of the two societies particularly fascinating; the joint organisation of these events in fact signals the shared intention to proceed along the path of scientific exchange. The topics of the other sessions have been chosen by the Scientific Committee on the basis of their scientific relevance and topicality, with particular attention paid to the selection of the speakers. The SIB sessions will range from Signal Transduction and Biomolecular Targets, Protein Misfolding and its Relationship with Disease, Emerging Techniques in Biochemistry, Gene Silencing, Redox Signalling and Oxidative Stress, Lipids in Cell Communication and Signal Transduction, Mitochondrial Function and Dysfunction.

Magnetic effects across biochemistry, molecular biology and environmental chemistry: Genes, brain and cancer under magnetic control provides an overview of the influence of magnetism upon molecular and biochemical processes and its impact on disease, health and organisms.This book provides an understanding of key concepts behind magnetic fields before exploring their biological significance. It elucidates when and why magnetic effects arise, how they function, and how they can be utilized. Molecular mechanisms underlying magnetic effects and the impact of magnetism on genes are explored. Additionally, magnetic control in treatment of diseases, including cancer, heart disease, and neurological disease is investigated. This book explores a rapidly developing and intriguing field of science, providing a basis for future study in the field of magneto-biology, and is a useful reference for researchers across biochemistry, molecular biology, biophysics and related fields.• Explores the mechanisms of magnetic fields and magnetic isotope effects at a molecular and biochemical level • Identifies key background concepts and function of magnetic fields across biology and chemistry • Covers magnetic control in the context of genes, including key processes such as DNA synthesis, magnetically induced DNA damage, and magnetic control of DNA repair • Demonstrates a new, radical pair mechanism as a means to stimulate ATP synthesis in living organisms for prevention of diseases

This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers