This Research Topic is Volume II of a series. The previous volume, which has attracted over 40,000 views can be found here: Bioengineering and Biotechnology Approaches in Cardiovascular Regenerative MedicineCardiovascular diseases continue to be the leading cause of death while available clinical interventions have limited contributions to heart repair and regeneration. Cardiovascular regenerative medicine, characterized by a unique integration of biology, physical sciences, and bioengineering principles, has emerged as one of the most promising fields of translational research to regenerate the adult human heart.

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

The Research Topic is organized in the framework of the project BIORECAR (grant number: 772168; http://www.biorecar.polito.it/index.html)

The guest editors of this eBook have accepted 10 very high-quality submissions for inclusion in a special issue of Frontiers in Physiology. The key difference between this eBook and contemporary fetal physiology related literature is that this Research Topic summarizes additional insights into the physiological link between physiologically understandable mathematical indices of fetal signals and the developing cardiovascular functions in fetal health and compromises. This book should be of considerable help to researchers, professionals in fetal monitoring device industries, academics, and graduate students from a wide range of disciplines. The text provides a comprehensive account of recent research in this emerging field and we anticipate that the concepts presented here will generate further research in this field.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.