Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.

conjugate biomaterials have profoundly impacted the medical field. --

Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors. - A comprehensive overview of switchable and responsive materials and surfaces - Includes in depth analysis of thermo-responsive polymers, photonic sensitive materials and peptide-based surfaces - Detailed exploration of biological interactions of responsive and switchable surfaces, covering stimuli-sensitive polymers for drug delivery, surfaces with proteins/cells and application of polymers in medical devices

This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.

Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices

In the last couple of decades, research in the area of tissue engineering has witnessed tremendous progress. The focus has been on replacing or facilitating the regeneration of damaged or diseased cell, tissue or organs by applying a biomaterial support system, and a combination of cells and bioactive molecules. In addition new smart materials have been developed which provide opportunities to fabricate, characterize and utilize materials systematically to control cell behaviours and tissue formation by biomimetic topography that closely replicate the natural extracellular matrix. Following on from Smart Materials for Tissue Engineering: Fundamental Principles, this book comprehensively covers the different uses of smart materials in tissues engineering, providing a valuable resource for biochemists, materials scientists and biomedical engineers working in industry and academia.

The current interest in developing novel materials has motivated an increasing need for biological and medical studies in a variety of dinical applications. Indeed, it is dear that to achieve the requisite mechanical, chemical and biomedical properties, especially for new bioactive materials, it is necessary to develop novel synthesis routes. The tremendous success of materials science in developing new biomaterials and fostering technological innovation arises from its focus on interdisciplinary research and collaboration between materials and medical sciences. Materials scientists seek to relate one natural phenomenon to the basic structures of the materials and to recognize the causes and effects of the phenomena. In this way, they have developed explanations for the changing of the properties, the reactions of the materials to the environment, the interface behaviors between the artificial materials and human tissue, the time effects on the materials, and many other natural occurrences. By the same means, medical scientists have also studied the biological and medical effects of these materials, and generated the knowledge needed to produce useful medical devices. The concept of biomaterials is one of the most important ideas ever generated by the application of materials science to the medical field. In traditional materials research, interest focuses primarilyon the synthesis , structure, and mechanical properties of materials commonly used for structural purposes in industry, for instance in mechanical parts of machinery.

This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.