- Sensortechnik und Sensorelektronik haben sich im vergangenen Jahrzehnt immens weiterentwickelt - der vorliegende Band ist die erste Anleitung zum Selbst- und Fernstudium dieses Gebietes - anwendungsorientiert und praxisnah ausgerichtet - für alle, die chemische Sensoren und Biosensoren einsetzen wollen

A biosensor is a device in which a bioactive layer lies in direct contact with a transducer whose responses to change in the bioactive layer generate eloctronic signals for interpretation. The bioactive layer may consist of membrane-bound enzymes, anti-bodies, or receptors. The potential of this blend of electronics and biotechnology includes the direct assay of clinically important substrates (e.g. blood glucose) and of substances too unstable for storage or whose concentrations fluctuate rapidly. Written by the leading researchers in the field, this book reflects the most current developments in successfully constructing a biosensor. Major applications are in the fields of pharmacology, molecular biology, virology and electronics.

Nanotechnology is a budding field and has a pivotal role in sensing. Nanomaterials exist in various forms such as nanoparticles, nanoclusters, nanobelts, and nanospheres. These nanomaterials act as sensing interfaces and immobilization surfaces for various biomolecules such as enzymes, DNA, and antigens. Therefore, the preparation and characterization of these nanoparticles play an important role in sensing devices. This handbook has evolved from the authors’ teaching and research experience in the field of nanoparticle biosensing. It encompasses protocols for the synthesis of various forms of metal oxide nanoparticles; study of the various characterizing techniques that help deduce the shape, size, and morphology of these nanoparticles; and applications of these nanoparticles in the field of biosensors. It presents voltammetry techniques such as cyclic, linear wave, wave pulse, and differential pulse voltammetry, throws light on the interactions of nanomaterials and biomolecules, and discusses microfluidic devices, which due to their unique capability of miniaturization fascinate many researchers. It is a practical and user-friendly textbook that introduces the various basic principles and practical information that will help undergraduate and advanced-level students and researchers understand the science behind nanoscale sensing.

A biosensor is a device for the detection of an analyte that combines a biological component with a physiochemical detector component. A typical biosensor consists of three parts: a sensitive biological element, a transducer in between and a detector element. The most widespread example of a commercial biosensor is the blood glucose biosensor, which uses an enzyme to break blood glucose down. In so doing it transfers an electron to an electrode and this is converted into a measure of blood glucose concentration. The high market demand for such sensors has fuelled development of associated sensor technologies. This book covers recent developments that combine the fields of biotechnology and electrical engineering with applications in the detection of very low levels of chemicals and biological agents in the body. It provides an authentic overview of a wide range of biosensing systems, discussing the elements of different transducers used in sensors and the selective elements that are employed. The style is relatively non-mathematical and informal in approach. The contents of the book will be ideal for graduate and postgraduate students of biotechnology, analytical and physical chemistry. It will also be invaluable to all those concerned with the environmental and biomedical applications of such biosensing systems.

Biosensors and Modern Biospecific Analytical Techniques further expands the Comprehensive Analytical Chemistry series' coverage of rapid analysis based on advanced technological developments. This 12-chapter volume summarizes the main developments in the biosensors field over the last 10 years. It provides a comprehensive study on the different types of biosensors, including DNA-based, enzymatic, optical, self-assembled monolayers and the third generation of biosensors. As well as many technological developments on bioanalytical microsystems and new materials for biosensors, antibody and immunoassay developments have a prominent place in the book.* Provides a comprehensive study on the different types of biosensors* Applications covered include environmental analysis, bioprocess monitoring and biomedicine* An indispensable resource for those working in analytical chemistry

Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems. - Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers - Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications - Offers an insight into how to develop cost-effective diagnostics for early detection of cancer

Proceedings of the NATO Advanced Research Workshop, Smolenice, Slovakia, May 4-8, 1997

Of all the recent discoveries in biotechnology, that of biosensor is one of those which has seen an exponential expansion over the last few years. This evolution corresponds with the increasing need for measuring devices that can follow continuously changing biological processes. Biosensors can meet this need provided that their signals include all the information necessary for an understanding of the process, especially concerning the nature and concentration of the species present in the sample medium. It is well known that sensors form the basis of all instrumental analysis systems, but they also represent the limiting factors of such systems. In this book, we restrict ourselves to the description and study of sensors, leaving aside the different aspects of signal and data treatment. We believe, however, that it is important to stress the multifaceted character of biosensors, and the applications and economic factors which follow. Biosensor construction is essentially based on the immobilization of a bioreceptor on the corresponding transducer. The reader will find that there are a large variety of techniques for immobilizing enzymes, cofactors and mediators, and even microorganisms, immunoagents, e now commercially available. Other types of tissues, and organelles. A large part of this book is devoted to enzyme biosensors are discussed, with regard to both the principles of their sensors, which is hardly surprising considering that they have been operation, and their construction.

Discussing the role biosensors play in detecting and monitoring environmental substances, Biosensors and Environmental Health provides key facts that can be applied to other areas of health and disease and a "mini-dictionary" of key terms and summary points. It covers personal toxicity testing, soil and risk assessment, pesticide, insecticides, parasites, nitrate, endocrine disruptors, heavy metals, food contamination, whole cell bioreporters, bacterial biosensors, antibody-based biosensors, enzymatic, amperometric and electrochemical aspects, quorum sensing, DNA-biosensors, cantilever biosensors, bioluminescence and other methods and applications. The contributors are leading authorities and the book is essential reading for environmental scientists, toxicologists, medical doctors, health care professionals, pathologists, biologists, biochemists, chemists and physicists, general practitioners as well as those interested in disease and sciences in general.

This book offers comprehensive coverage of biomarker/biosensor interactions for the rapid detection of weapons of bioterrorism, as well as current research trends and future developments and applications. It will be useful to researchers in this field who are interested in new developments in the early detection of such. The authors have collected very valuable and, in some aspects indispensable experience in the area i.e. in the development and application of portable biosensors for the detection of potential hazards. Most efforts are centered on the development of immunochemical assays including flow-lateral systems and engineered antibodies and their fragments. In addition, new approaches to the detection of enzyme inhibitors, direct enzymatic and microbial detection of metabolites and nutrients are elaborated. Some realized prototypes and concept devices applicable for the further use as a basis for the cooperation programs are also discussed.There is a particular focus on electrochemical and optical detection systems,including those employing carbon nanotubes, quantum dots and metalnanoparticles. The authors are well-known scientists and most of them are editors of respected international scientific journals. Although recently developed biosensors utilize known principles, the biosensing devices described can significantly shorten the time required for successful detection and enhance efforts in more time-consuming directions, e.g. remote sensing systems and validation in real-sample analysis.The authors describe advances in all stages of biosensor development: theselection of biochemical components, their use in biosensor assembly, detection principles and improvements and applications for real sample assays.