The ambitious goal of this volume is to provide – in chapters written by accomplished scientists and experts in their field – a comprehensive overview of the currently available information related to the therapeutic utility of adult bone marrow-derived cells. With excitement generated almost daily about the possible uses of stem cells to treat human disease, but the controversy surrounding their use still raging, adult bone-marrow derived cells are more readily available, and have a staggering range of uses.

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

"The highly acclaimed foundation textbook Rubin's Pathology: Clinicopathologic Foundations of Medicine, now in its sixth edition, provides medical students with a lucid discussion of basic disease processes and their effects on cells, organs, and people. The streamlined coverage includes only what medical students need to know and provides clinical application of the chapter concepts. Icons signal discussions of pathogenesis, pathology, epidemiology, etiological factors, and clinical features. Rubin's Pathology is liberally illustrated with full-color graphic illustrations, gross pathology photos, and micrographs. The sixth edition is completely updated with expanded and revised context. A suite of exciting online tools for students includes a fully searchable e-text with all images, 140 interactive case studies, 1500 audio review questions, summary podcast lectures, and a selection of mobile flash cards for iPhone, iPod, and BlackBerry from the new Rubin's Pathology Mobile Flash Cards. Resources for faculty include a 600 question test generator and chapter outlines and objectives"--Provided by publisher.

This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.

This collection of current and future concepts of neovascularization offers fascinating insights into refining a powerful therapeutic tool which has not yet had the chance to live up to the expectations and needs of the medical community. It examines current refinements in the fundamental concept of neovascularization and describes the most recent developments, which in the future might pave the way towards a new era of therapeutic applications.

International Workshop organised by the Marcel Mérieux Foundation, 21 to 23 June 2000. The debate over the ethical issues raised by stem cell research concerns essentially the practice of taking cells from human embryos and the consequent destruction of the embryo. This work, going to the heart of the controversy over such manipulations, discusses the ethical question of the legal status of the embryo. At the moment when, in France, the bioethics laws have come up for review, questions regarding the statute of the embryo return in the heart of scientific debates. Breakthroughs in the field of embryonic stem cell biology offer a glimpse of the considerable therapeutic possibilities. Research Institutes and Governments, hailed by these new therapeutic perspectives, are attempting to put in place modes of regulation this research that both respond to citizen's aspirations and conform to ethical norms.

This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease

This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.