This book introduces the reader to all the key concepts and technologies needed to begin developing their own bioinformatics tools. The new edition includes more bioinformatics-specific content and a new chapter on good software engineering practices to help people working in teams.

This book introduces the reader to all the key concepts and technologies needed to begin developing their own bioinformatics tools. The new edition includes more bioinformatics-specific content and a new chapter on good software engineering practices to help people working in teams.

V.1: Basic technologies: From Genomes to drugs with bioinformatics (Thomas Lengauer); Sequence analysis (Martin Vingron); Structure, properties and computer identification of eukaryotic genes (Victor Solovyev). Analyzing regulatory regions in genomes (Thomas Werner). Homology modeling in biology and medicine (Roland L. Dunbrack, Jr.). Protein structure prediction (Ralf Zimmer and Thomas Lengauer). Protein-ligand docking in drug design (Matthias Rarey). Modellimg protein-protein and protein-DNA docking (Michael J. E. Sternberg and Gidon Moont). v.2: Applications: Integrating and accessing molecular biology resources (David P. Hansen and Thure Etzold). Bioinformatics support of genome sequencing projects (Xiaoqiu Huang). Analysis of sequence variations (Christopher S. Carlson, Mark J. Rieder and Deborah A. Nickerson). Proteome analysis (Pierre-Alain Binz, Elisabeth Gasteiger, Jean-Charles Sanchez, Amos Bairoch, Denis F. Hochstrasser, Ron D. Appel). Target finding in genomes and proteomes (Stephanie Fuhrman Liang, Xiling Wen and Roland Somogyi). Screening of drug databases (Martin Stahl, Matthias Rarey and Gerhard Klebe). Future trends (Thomas Lengauer).