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Genre | : |
Author | : |
Publisher | : |
Release | : 1994 |
File | : 482 Pages |
ISBN-13 | : NWU:35558003391980 |
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Genre | : |
Author | : |
Publisher | : |
Release | : 1994 |
File | : 482 Pages |
ISBN-13 | : NWU:35558003391980 |
Tumor Immunology and Immunotherapy - Integrated Methods Part B, Volume 636 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this update include Quantification methods of Transforming Growth Factor beta (TGF??) activity in the setting of cancer immunotherapy, Decoding cancer cell death-driven immune cell recruitment: An in vivo method for site-of-vaccination analyses, Tracking and interrogating tissue-resident and recruited microglia in brain tumors, Metabolomics and lipidomics of the tumor microenvironment, Monitoring abscopal responses to radiation in mice, and much more. Provides an array of authors who are authorities in the field Presents comprehensiveness coverage of the topics Includes a broad level of detail and in-depth coverage
Genre | : Science |
Author | : |
Publisher | : Academic Press |
Release | : 2020-04-01 |
File | : 404 Pages |
ISBN-13 | : 9780128206676 |
Tumor Immunology and Immunotherapy - Cellular Methods Part A, Volume 631, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters include Detection of intracellular cytokine production by T cells with flow cytometry, High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers, In vitro assays for effector T cell functions and activity of immunostimulatory antibodies, Ex vivo energetic profiling of tumor cells and T cells from mouse models and human samples, A cytofluorimetric assay to evaluate T cell polyfunctionality, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology
Genre | : |
Author | : Nils-Petter Rudqvist |
Publisher | : Academic Press |
Release | : 2020-01-15 |
File | : 554 Pages |
ISBN-13 | : 9780128186732 |
Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry, High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more. - Authored by leaders in the field of enzymology - Provides a comprehensiveness level of discussion on the field - Presents a highly specialized group of topics that delve deep into new updates and future prospects
Genre | : Science |
Author | : |
Publisher | : Academic Press |
Release | : 2020-02-28 |
File | : 346 Pages |
ISBN-13 | : 9780128188750 |
This publication provides a comprehensive account of the known groups of human tumour antigens, and the immune effector cells involved in tumour rejection. Chapters dealing with all the major groups of human tumour antigens are included, covering differentiation antigens, testes-associated antigens, CEA, mucin, viral antigens, anti-idiotypic antibodies as antigens, and fusion proteins. The role of heat shock proteins as mediators of tumour immunity is discussed and consideration is given to the immune mechanisms which mediate tumour rejection in both human and animal systems. The application of antibody targeting to identify cancers, and the mechanisms by which tumours evade immune detection and/or destruction is covered in detail. Although the focus of this publication is experimental, as with other recent publications progress in clinical immunotherapy is included in some detail, to provide postgraduate and post-doctoral scientists with in-depth reviews of the field.
Genre | : Medical |
Author | : R.A. Robins |
Publisher | : Springer Science & Business Media |
Release | : 2013-03-14 |
File | : 268 Pages |
ISBN-13 | : 9789401709637 |
Tumor Immunology and Immunotherapy – Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more. Contains content written by authorities in the field Provides a comprehensive view on the topics covered Includes a high level of detail
Genre | : Science |
Author | : |
Publisher | : Academic Press |
Release | : 2020-01-29 |
File | : 588 Pages |
ISBN-13 | : 9780128186763 |
Immunotherapy of Cancer provides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology. - Provides information on cancer research, including outstanding and original reviews - Covers the current progress and emerging concepts in cancer inflammation, immunology, and immunotherapy - Suitable for researchers and students studying, and interested in, the field of immunotherapy for cancer - Ideal for those studying cancer inflammation, tumor immunology, cancer immunotherapy, dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments
Genre | : Medical |
Author | : |
Publisher | : Academic Press |
Release | : 2015-07-29 |
File | : 407 Pages |
ISBN-13 | : 9780128025543 |
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.
Genre | : Medical |
Author | : Joseph D. Rosenblatt |
Publisher | : Springer Science & Business Media |
Release | : 2013-10-25 |
File | : 369 Pages |
ISBN-13 | : 9781461488095 |
Understanding the immunology of different cancers has led to great advances in developing cancer immunotherapies which are successfully used in generating effective anti-tumour immune responses. Head and neck cancers are no exception and various immunotherapies are now under study for the treatment of this diverse group of diseases. The articles in in this eBook provide a range of topics that highlight some of the latest advances in head and neck cancer immunology and immunotherapy. The authors of these articles provide their unique insight and expertise and suggest future directions for translational clinical research.
Genre | : |
Author | : Rasha Abu-Eid |
Publisher | : Frontiers Media SA |
Release | : 2019-06-19 |
File | : 64 Pages |
ISBN-13 | : 9782889458394 |
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Comprehensive treaty covering all aspects of immuno-oncology (IO) - Novel strategies for delivery of IO therapeutics and vaccines - Forecasting on the future of nanotechnology and drug delivery for IO
Genre | : Medical |
Author | : Mansoor M. Amiji |
Publisher | : Academic Press |
Release | : 2021-08-18 |
File | : 550 Pages |
ISBN-13 | : 9780128236376 |