The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules. The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction. The second part describes the macromolecular interactions responsible for the anchorage of cells to the underlying extracellular basement membrane. The experimental approaches detailed in the text not only reveal how the molecular components of the dermal-epidermal junction have been elucidated, but also highlight how mutations in the genes which encode these molecules are responsible for many heritable skin diseases. Leukocytes continually infiltrate the skin and patrol it for potentially harmful pathogens. Control of leukocyte adhesion to resident cells within the skin and to the extracellular matrix plays a key role in controlling these processes. These mechanisms constitute the primary focus of the final section. The pivotal role of leukocytes is examined in conjunction with the chronic inflammatory diseases which arise when components of the skin's finely tuned defence strategy go awry and the potential for these anomalies to be pinpointed as important immunotherapeutic targets for skin diseases.

The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure

Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.

The key aim of the proposed chapter is to provide readers a brief description for the most important parts of the field of circulating tumor cells (CTCs): the core techniques, including negative and positive selection-based CTC isolation, and the differences between them. Most importantly, we will also review the clinical applications and important findings in clinical trials. The evidence-based review will not only help clinicians use CTCs to predict recurrence and foresee the disease-related outcomes but also to inspire the researchers in this field to conduct further investigations.

**Selected for Doody's Core Titles® 2024 in Dermatology**For dermatology residents and trainees, as well as those in clinical practice, Dermatology is the leading reference for understanding, diagnosing, and treating the full spectrum of skin disease—and is the key resource that residents rely on throughout their training and certification. Widely recognized for its easy-in, easy-out approach, this revised 5th Edition turns complex information into user-friendly visual content through the use of clear, templated chapters, digestible artwork, and easy-to-follow algorithms and tables. This two-volume masterwork provides complete, authoritative coverage of basic science, clinical practice of both adult and pediatric dermatology, dermatopathology, and dermatologic surgery—more than any other source, making it the gold standard reference in the field today. - Simplifies complex content in a highly accessible, highly visual manner, with 1,100+ tables; 2,600+ figures, including numerous disease classification algorithms as well as diagnostic and therapeutic pathways; and over 1,500 additional figures and tables online. - Utilizes weighted differential diagnosis tables and a "ladder" approach to therapeutic interventions. - Any additional digital ancillary content may publish up to 6 weeks following the publication date. - Features an intuitive organization and color-coded sections that allow for easy and rapid access to the information you need. - Retains an emphasis on clinicopathologic correlations, with photomicrographs demonstrating key histologic findings adjacent to clinical images of the same disorder. - Contains updated treatment information throughout, including immune checkpoint inhibitors, JAK inhibitors, and monoclonal antibodies for a wide range of conditions such as psoriasis, atopic dermatitis, alopecia areata, vitiligo, and skin cancers. - Provides up-to-date information on genetic and molecular markers and next-generation sequencing as it applies to dermatologists. - Features new videos, including cryosurgical and suturing techniques, treatment of rhinophyma via electrosection, and neuromodulator treatment of axillary hyperhidrosis. - Includes new WHO classifications of skin tumors, new FDA pregnancy drug labeling, and new ACR/EULAR criteria for vasculitis and lupus erythematosus. - Includes new sections on confocal microscopy and artificial intelligence.

Brain-immune interactions are essential to maintain health and their dysfunction contributes to diverse human diseases. Recent data show that haematopoietic processes and immune organs are under central autonomic control. Deficient regulation of inflammatory events contributes to brain diseases, whereas acute or chronic brain injury is linked with the development of systemic inflammatory conditions or immunosuppression. At present, common disorders with high socio-economic burden such as cancer, cardiovascular-, neuroinflammatory- and neurodegenerative diseases, asthma, allergies, autism, psychiatric conditions and sepsis are believed to be influenced, at least in part, by the dysfunction of brain-immune communication. Since the median age of the world's population is increasing rapidly, it is expected that the burden of common non-communicable diseases will further increase, which represents a huge challenge to the health care systems worldwide. Thus, there is an increasing demand to understand and treat complex diseases, many of which are age-related, and this is not possible unless the fine-tuned communication between large systems -such as the nervous and the immune system- is comprehensively understood. Although it is impossible to cover all areas of relevant research in this field, papers in this eBook give some insight to a few important aspects of brain-immune interactions and their contribution to disease. We hope that this collection could stimulate further relevant research and facilitate discussions to support the understanding of the highly complex interactions between the immune system and the brain in health and disease.

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today's busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application. - Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. - Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells, as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion. - Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors. - Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout. - Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review. - Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.