The amazing complexity of human anatomy and physiology is dependent upon its single most basic unit: the cell. Humans can attribute their overall health to homeostasis, the balance of activity within properly functioning cells. Additionally, cells are affected by the food we eat along with the microscopic entities that make us ill. Cells and Human Health, Third Edition covers how cells work to maintain human health and immunity as well as the history of cell discovery and the basics of cellular activity. Readers will also learn the processes of illnesses and corresponding genetics that compromise a cell's proper activity in the human being.

Since the second edition of this text was published, many new environmental incidents have occurred, including another nuclear disaster, a mine disaster in the United States, and the Gulf of Mexico oil spill. Updated throughout the text, Ecosystems and Human Health: Toxicology and Environmental Hazards, Third Edition explores the broad range of env

Exam Board: BTEC Level: KS4 Subject: Vocational First Teaching: September 2016 First Exam: June 2018 Help your students gain the academic expertise and employability skills needed for further progression in education or the workplace with this textbook, fully updated to reflect the new structure and content of the 2016 Level 3 BTEC qualification. - Prepare your students for new external assessment requirements with teaching guidance and tips - Contextualise knowledge and build practical understanding of concepts with real-world issues and scenarios - Provide opportunities to stretch and challenge Distinction students - Help students prepare for assignments with activities linked to assessment criteria

"Environmental Health" has established itself as the most succinct and comprehensive textbook on the subject. This extensively revised and rewritten third edition continues this tradition by incorporating new developments and by adding timely coverage of topics such as environmental economics and terrorism. As in previous volumes, the new edition presents balanced assessments of environmental problems, examining their local and global implications, their short- and long-range impacts, and their importance in both developed and less developed countries of the world. The "Third Edition" also addresses emerging issues such as environmental justice, deforestation, the protection of endangered species, multiple chemical sensitivity, and the application of the threshold concept in evaluating the effects of toxic and radioactive materials. Whether discussing acid rain, ozone depletion, global warming, or more traditional subjects such as the management and control of air, water, and food, Dade Moeller emphasizes the need for a systems approach. As with previous volumes, "Environmental Health, Third Edition," offers a depth of understanding that is without peer. While it covers technical details, it is also a book that anyone with an interest in the environment can pick up and browse at random.

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

The formation of placenta can be viewed as a controlled process of inflammation or cancer development in which cell proliferation, invasion, and immune surveillance or evasion are promoted in a time- and space-specific manner. This suggests that the functions of prostasin are mainly active in pathophysiological conditions, more so than those in basic or normal physiological conditions. The uniqueness of the prostasin serine protease is its membrane anchorage via a glycosylphosphatidylinositol moiety. This anchorage exposes the entire prostasin molecule to the outside while still being immobilized on the cell membrane and gives prostasin a better chance to be used as a biomarker or drug target. As presented in placenta development, the equilibrium between growth and differentiation dictates healthy and disease states.This book provides readers with an integrated knowledge on serine protease prostasin, starting with its discovery, protein isolation, cDNA, and gene cloning, to its functions in physiology and pathophysiology, and to its application in the development of therapeutics. This is the first-of-its-kind book that covers the history, present state of knowledge, and future perspectives of the prototypic glycosylphosphatidylinositol-anchored epithelial extracellular serine protease prostasin, which is a key player in the regulation and maintenance of the extracellular fluid homeostasis. The chapters encapsulate all that has been learned about prostasin in the technical sophistication, but more importantly, also highlight a critical analysis on the problems with the current state of research and outline the challenges for the future.

Oceans and Human Health highlights an unprecedented collaboration of environmental scientists, ecologists and physicians working together on this important new discipline, to the benefit of human health and ocean environmental integrity alike. Oceanography, toxicology, natural products chemistry, environmental microbiology, comparative animal physiology, epidemiology and public health are all long established areas of research in their own right and all contribute data and expertise to an integrated understanding of the ways in which ocean biology and chemistry affect human health for better or worse. This book introduces this topic to researchers and advanced students interested in this emerging field, enabling them to see how their research fits into the broader interactions between the aquatic environment and human health. - Color illustrations of aquatic life and oceanic phenomena such as hurricanes and algal blooms - Numerous case studies - Socio-economic and Ethical Analyses place the science in a broader context - Study questions for each chapter to assist students and instructors - Risks and remedies sections to help define course modules for instruction

The Chlamydomonas Sourcebook, 3rd Edition Cell Motility and Behavior (Volume 3) The gold-standard reference?introducing this multidisciplinary science,?fully revised and updated with the latest discoveries Originally published as the standalone Chlamydomonas Sourcebook, then expanded as the third volume in a three-part comprehensive gold-standard reference,?The Chlamydomonas Sourcebook: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community. Reflecting the significant advancement in?the understanding of the role of basal bodies and cilia play in human diseases, this volume employs quantitative proteomics and mass spectroscopy as well as?cryo?EM tomography and single particle?cryo?EM. Other topics such as current insights?on?mitosis and cytokinesis, ciliary assembly and motility, intraflagellar?transport, and more help build an understanding of human diseases of the cilium. Cell Motility and Behavior presents the latest in research and best practices, making this a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, and biochemistry; crop scientists; plant physiologists; and plant, molecular, and human disease biologists. Provides an essential reference to a model species for the study of mechanisms of motility in free living cells? Includes methods for Chlamydomonas motility research? Includes a table listing the known proteins (with NCBI accession numbers) for each structure discussed, and the known mutations that affect each structure and process

Principles of Cell Biology, Third Edition is an educational, eye-opening text with an emphasis on how evolution shapes organisms on the cellular level. Students will learn the material through 14 comprehensible principles, which give context to the underlying theme that make the details fit together.