In the years following publication of the DSM-5(R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit. Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5(R), which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

As scientific knowledge grows about the role of the brain in mental disorder, no clinician can afford to be uninformed about neurobiology. This accessible primer provides the basic grounding in neuroscience that all contemporary mental health professionals need. Readers are first guided through the fundamentals of neuroanatomy, neurochemistry, and psychiatric genetics. Chapters then illuminate the neurobiological underpinnings of a range of frequently encountered disorders--including ADHD, substance abuse, mood and anxiety disorders, schizophrenia, and learning and cognitive problems--giving particular attention to the impact of psychosocial risk factors on the brain. Also examined are ways that both pharmacological and psychological interventions have been shown to alter brain chemistry as they bring about a reduction in symptoms.

Well-known for its authoritative and comprehensive coverage, complete treatment of pediatric pathophysiology, and the most extensive illustration program in its field, this textbook features expert content on everything from the general principles of pathophysiology to detailed discussions of genetics and specific diseases. Chapters on alteration present the pathophysiology, clinical manifestations, and evaluation and treatment of each disease to help you learn to identify normal anatomy and physiology, as well as alterations of function in adults and in children. Unparalleled coverage of disease processes makes this text the most comprehensive pathophysiology text available. The largest full-color art program in the field illustrates the clinical manifestations of diseases and disease processes Consistent presentations of each disease with pathophysiology, clinical manifestations, and evaluation and treatment help you find the information you need quickly and easily. Ten separate pediatric chapters cover the pathophysiologic effects on children. Aging content is highlighted throughout the text. An Introduction to Pathophysiology section at the beginning of the text provides a solid start to the basics of the study of disease. Algorithms and flowcharts of diseases and disorders illustrate the disease process in an easy-to-understand format. Nutrition and Disease boxes present evidence-based information on the relationship between health promotion through diet and disease. Updated content on leukocytes in pain modulation, seizure disorders, brain injuries and disorders, acute encephalopathies, reproductive disorders, and much more keep you at the cutting edge of this constantly changing field. What’s New? boxes highlight the most current research and findings to ensure you have the most up-to-date information. New animations, review questions, Key Points, and an audio glossary have been added to the Evolve companion website to strengthen your understanding of key concepts. Media Resources Lists encourage you to develop a study plan to master the important content in each chapter.

Clinical Neuroanatomy offers an extensive review of higher cortical – behavioral functions and their anatomical substrates. The book begins with a review of the basic internal and external morphology, major nerve and fiber tracts, behavioral correlates, and clinical syndromes associated with spinal cord, brain stem, and cerebellum, reacquainting readers with the functional anatomy of the subtentorial central nervous system. The central chapters offer more detailed, integrated, and, at times, theoretical models of cortical systems and their internal organization. Additional chapters highlight vascular anatomy and neurochemical systems. Nearly 300 illustrations help identify key structures and pathways, as well as providing clinical and pathological examples.

"Between Sanity and Madness: Mental Illness from Homer to Neuroscience traces the extensive array of answers that various groups have provided to questions about the nature of mental illness and its boundaries with sanity. What distinguishes mental illnesses from other sorts of devalued conditions and from normality? Should medical, religious, psychological, legal, or no authority at all respond to the mentally ill? Why do some people become mad? What treatments might help them recover? Despite general agreement across societies regarding definitions about the pole of madness, huge disparities exist on where dividing lines should be placed between it and sanity and even if there is any clear demarcation at all. Various groups have provided answers to these puzzles that are both widely divergent and surprisingly similar to current understandings"--

Assessing, Diagnosing, and Treating Serious Mental Disorders uniquely provides information that is useful across mental health, psychopathology, practice, and human behavior and development classes, particularly for psychopathology and advanced mental health practice courses. DSM-IV-TR diagnostic criteria is provided for each mental disorder discussed in the textbook, and detailed comparisons to DSM-5 are included. This book represents a new wave of social work education, focusing on mental disorders as an interaction among neurobiology, genetics, and ecological social systems. Edward Taylor argues that most all mental disorders have a foundation within the person's brain that differentially interacts with the social environment. Therefore, how the brain is involved in mental disorders is covered far more comprehensively than found in most social work textbooks. However, the purpose is not to turn social workers into neuroscientists, but to prepare them for educating, supporting, and where appropriate providing treatment for, clients and families facing mental illness. Entire chapters are dedicated to explaining bioecological and other related theories, family support and intervention, and assessment methods. To help students conceptualize methods, the book includes specific steps for assessing needs, joining, and including families in mental health treatment decisions. Methods for helping families become part of the treatment team and for providing in-home interventions are highlighted. Throughout the book, professors and students can find helpful outlines and illustrations for how to understand, assess, and treat mental disorders.

As an increasing number of children and adolescents with psychiatric symptoms go unrecognized in our current healthcare system, the ability to identify and treat these issues in multiple healthcare settings has become vitally important. With access to primary care providers increasing and a shortage of child psychiatric providers, collaboration between psychiatric, pediatric and family advanced practice nurses is essential to improving care for this vulnerable population. Child and Adolescent Behavioral Health provides a practical reference to aid in this endeavour. Written and reviewed by over 70 nurse experts, it is a must-have reference for all practitioners caring for children and adolescents.

Updated thoroughly, this comprehensive text highlights the most important issues in cognitive neuroscience, supported by clinical applications.

With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What's New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available! Over 1,200 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes - more than in any other pathophysiology text. A fully updated glossary includes 1,000 terms, and makes lookup easier by grouping together similar topics and terms. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Chapter summary reviews provide concise synopses of the main points of each chapter. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. EXTENSIVELY Updated content reflects advances in pathophysiology including tumor biology invasion and metastases, the epidemiology of cancer, diabetes mellitus, insulin resistance, thyroid and adrenal gland disorders, female reproductive disorders including benign breast diseases and breast cancer, and a separate chapter on male reproductive disorders and cancer. NEW! Chapter on epigenetics and disease. Additional What's New boxes highlight the most current research and clinical development.