Clinical and Translational Perspectives on Wilson Disease brings together the genetics, cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Created to meet the diverse needs of the clinical and research communities surrounding Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate 'basic science' aspects of Wilson disease, presenting a guide for researchers to understand the clinical disorder on which their research is focused and fostering constructive dialogue and progress for this puzzling disorder. - Delivers numerous, succinct, expert chapters with summaries designed for quick reference - Includes a 'How-to appendix' for diagnosis and management tips - Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and Monitoring translates both clinical and experimental findings into a comprehensive approach for anyone involved in research and patient care. While the clinical variability of Wilson Disease poses a challenge from a diagnostic approach, the book uses the translational impact of new research findings to relate to new treatment concepts. Comprehensive chapters include common knowledge, guideline consensus statements, and discussions of clinical evidence. This is a must-have reference for researchers and clinicians in translational research. - Delivers a substantial overview of evidence driven diagnostic pathways and treatment concepts for Wilson disease - Provides an understanding of the translational impact of new research findings in Wilson Disease - Reveals the current controversies in treatment decisions for Wilson disease, providing the best decisions for optimal patient care

The leading cause of death on Planet Earth is Metabolic Syndrome. Some 40% of all Earthlings now suffer from this condition which covers the gamut of Heart Disease, Cancer, Neurodegeneration, Liver disease, and PCOS. What is worth knowing is that ALL of these and related conditions start with Fatigue, known in scientific circles as "energy deficiency." 40% of the Earth's population has a formal clinical diagnosis that their mitochondria cannot make adequate levels of energy. [Cu]re Fatigue is a book devoted to educating the masses and their doctors exactly how and why this is happening. Our mitochondria make energy by a series of enzymes to work synergistically to create ATP, the cellular currency of energy. These mitochondrial enzyme reactions rely on minerals that are easily lost to stress. This book explains these concepts, how these challenges can be overcome and introduces the reader to a simple, proven Root Cause Protocol that is designed to generate more energy and end fatigue. This book is designed for those seeking the truth in human metabolism and those wanting to take back control of their health. It is one part textbook and one part user's guide based on a decade of research and client experience.

In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This book provides an excellent platform for understanding the chemical processes involved in food transformation. Starting with the examination of major food components, such as water, carbohydrates, lipids, proteins and minerals, the author further introduces the biochemistry of digestion and energy metabolism of food ingredients. The last section of the book is devoted to modern food technologies and their future perspectives.

A comprehensive reference for pediatric liver diseases, updated to include innovative advances leading to improved diagnosis and treatment.

Pervasive nutritional deficiency disorders impact overall health, cognitive development, and susceptibility to chronic diseases. The absence of vital nutrients leads to weakened immune systems, stunted growth, cognitive impairments, and increased disease vulnerability. Particularly affecting vulnerable populations such as infants, children, pregnant women, and the elderly, these deficiencies pose risks that extend from compromised academic performance to chronic health issues. Causes and Management of Nutritional Deficiency Disorders delves into the web of nutrition-related challenges, exploring the root causes and effective management strategies that form the backbone of this indispensable resource. The book sheds light on the critical importance of addressing nutritional deficiencies, beginning with the profound impact on physical health. Essential nutrients, from proteins to vitamins and minerals, are dissected in detail, unveiling their pivotal roles in immune system fortification, growth and development, bone health, and cardiovascular well-being.

Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants. - Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology - Explores the role of free radical mediated damage and toxicology - Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures

This contributed volume covers a comprehensive account of the sources, toxic biological as well as environmental impacts, and possible remediation strategies for contamination by heavy metals. In biological systems, toxic metals affect the integrity of cellular organelles and act as carcinogens causing chromosomal aberrations or as systemic toxicants leading to cardiovascular, neurobehavioral, and immunological disorders. In plants, they interfere with photosynthesis, fertility, metabolite, and chlorophyll synthesis. Toxicity induced by heavy metals involves mechanistic approaches that need to be understood properly. They cannot be degraded by biological or chemical means and thus can only be converted to less harmful forms. The conventional detection methods include biosensors, voltammetry, atomic absorption spectrometry, and inductively coupled plasma with atomic emission spectrometry. All such strategies for metal detection and mitigation strategies are covered in this title under one section. This book incorporates classical views along with modern scientific approaches to develop an understanding of the subject matter suitable for academicians, researchers, planners, policymakers, NGOs, and environmental consultancies and raise awareness on this concern. Topics representing diverse sections namely environmental impacts, biological effects, and methods used for detection and remediation have been included to address all possible contemporary issues on the topic in one concise volume.

Providing a comprehensive overview of antioxidants and nutraceuticals, including their sources, mechanisms of action, and health benefits, this new volume first covers the basics of the types of antioxidants as nutraceuticals, including the importance of phytochemical antioxidants and their nutritional and pharmacological intervention in the treatment of disease. It discusses the natural origins of antioxidants, classification, mechanisms of action, calculation of antioxidant potential of nutraceutical substances, safety, toxicity, and their significant involvement in the prevention of many degenerative and chronic diseases.