The gastrointestinal tract is a series of organs each with distinct mechanical functions. Each organ within the system brings food contents in the gut lumen to the site of absorption through separate mechanical functions. These mechanical functions are generated by a fine-tuned interaction between neuronal networks and active muscle layers. The passive components of the gastrointestinal wall such as the collagen-rich submucosa also play an important role in these mechanical actions. Clinical Mechanics in The Gut provides a thorough understanding of the anatomy and biomechanics of the physiological function and pathophysiology of the gastrointestinal tract. The book first gives an introduction to readers about the physical geometry of the gastrointestinal tract followed by a detailed explanation of biomechanical theory and its application to approximating and modeling gut mechanics. This is expanded further by detailed explanations of gut muscle and motor nerve functions in proceeding chapters. A biomechanical evaluation of disorders of regulatory mechanisms such as achalasia and Hirschsprung disease and disorders of effector mechanisms such as reflux disease, systemic sclerosis of the gastrointestinal tract and colonic diverticular disease are also included. Readers will, therefore, gain an understanding about clinical problems in gastroenterology from a bioengineering and modeling perspective. Clinical Mechanics in The Gut is a useful reference for gastroenterology researchers, biomedical engineers and systems biologists seeking to understand the physiology of the gut and applying this knowledge to surgical procedures, computer-based modeling systems and robotics.

This book is an introduction for students and young doctors at thebeginning of their career in diagnostic ultrasonography. It alsopresents the latest in innovations and techniques in gastrointestinalultrasonography. The reader will find basic aspects of ultrasonographyas well as highly advanced technical and research papers.

Biomechanics of the Gastrointestinal Tract is an up-to-date book for researchers on the study of the mechanical properties and the motor system of the gastrointestinal tract. A well-illustrated book, it provides a comprehensive overview to relevant tissue geometry, morphology and biomechanical theory. Separate chapters cover smooth muscle and nerve function including the application to animal and human studies of motility, symptoms and pain, determination of the true resting state, history-dependent properties, and tissue remodelling in disease. Several methods and diagnostic applications such as determination of in vivo length-tension diagrams and multimodal pain testing are completely new but will undoubtedly be used by many in the future. New non-invasive imaging techniques based on ultrasound, MR- and CT-scanning in combination with balloon distension are emerging as the techniques for future in vivo studies.

Presents the most comprehensive, clinically relevant coverage of nutrition in enteral and tube feeding. This new edition has been completely revamped by a multidisciplinary editorial team to reflect all of the latest technology and nutritional knowledge, as well as the new, collaborative nature of contemporary clinical practice. Delivers 21 brand-new chapters that address recent ASPEN clinical guidelines regarding pharmacotherapeutic issues and enteral formulations, including fluids and electrolytes, genetics, pre-, pro-, and synbiotics, food safety, regulatory issues, and more. This edition offers a new bonus CD-ROM containing review questions and answers and more, and a downloadable image collection of illustrations from the book.

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.

Clinical Gastrointestinal Endoscopy, 2nd Edition, by Drs. Gregory G. Ginsberg, Michael L. Kochman, Ian D. Norton, and Christopher J. Gostout, helps you master the latest endoscopic techniques and achieve optimal outcomes. See how to perform key nuances with procedural videos at www.expertconsult.com in addition to 1,000 photographs, upgraded endoscopic images, and anatomical drawings both in print and online. Written by some of today’s most prestigious specialists and with many new and fully updated chapters, this resource equips you to diagnose and treat the full range of GI disorders with state-of-the-art coverage of bariatric surgery, therapeutic EUS, device-assisted enteroscopy, image-guided therapy, intramural endotherapy, and much more. Get comprehensive details on a wide breadth of topics including anatomy, pathophysiology, and therapeutic management options in addition to the latest GI procedures and technologies. Advance your knowledge on the rapidly evolving state of clinical gastrointestinal endoscopy with expert multimedia guidance from some of today’s most prestigious specialists. Master new procedures with updates on the endoscopic management of bariatric surgery; EUS as a tool to direct endoscopic therapies; device-assisted enteroscopy for deep exploration of the small intestine; image-guided therapy to help detect cancer earlier; intramural endotherapy including the new POEM procedure; and much more. Keep current with both new and emerging technologies including the management of upper gastrointestinal familial adenomatous polyposis syndrome and ampullary tumors; post-bariatric endoscopy and endoscopic therapy; endoluminal bariatric techniques, and intramural/transmural endoscopy. See how to perform key procedures step by step with endoscopic videos at www.expertconsult.com, and access the complete text, online-only references, and all the illustrations. View techniques more clearly with upgraded endoscopic images and step-by-step illustrations in most chapters.

In this issue of Gastroenterology Clinics, guest editor Dr. Laurie Keefer brings her considerable expertise to the topic of Psychogastroenterology. This burgeoning, multidisciplinary field applies psychological science and practice to gastrointestinal health and illness, providing a patient-centered understanding of GI conditions with roots in the biopsychosocial model of illness. In this unique issue, top experts in psychogastroenterology present reviews on key topics across the spectrum of digestive disorders. - Contains 14 practice-oriented topics including stress, resilience, and the brain-gut axis; the future of brain-gut psychotherapies; psychological considerations in the management of food intolerances; working with trauma in the GI setting; addressing disparities in psychogastroenterology care; and more. - Provides in-depth clinical reviews on psychogastroenterology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Transabdominal ultrasound is accepted in clinical practice as a primary imaging procedure in the diagnostic work-up and follow-up of various disorders of the gastrointestinal tract. This book provides a comprehensive overview of ultrasound in the imaging of acute and chronic inflammatory conditions of the gastrointestinal tract as well as of neoplastic and infectious diseases. All authors are considered authorities in their specific fields, and the book includes many high-quality illustrations.

This fifth edition of the Autonomic Failure covers the many recent advances made in our understanding of the autonomic nervous system. There are numerous new chapters and extensive revisions of all other contributions. This volume makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby allowing more effective treatment. It continues to provide a rational guide to aid in the recognition and management of autonomic disorders for practitioners from a variety of fields, including neurology, cardiology, geriatric medicine, diabetology, and internal medicine.