This issue of Neurologic Clinics features a review of clinical neurogenetics as it pertains to the following disorders: Huntington Disease; Autism/ASD;Fragile X Tremor Ataxia Syndrome (FXTAS); Lysosomal Storage Diseases; Psychiatric Disorders; Dominant Spinocerebellar Ataxias; Metabolic Disorders; Friedreich Ataxia; ALS; Dementia; Neuromuscular Disorders; Stroke; Epilepsy; and Dystonia.

Secondary headaches account for about 10% of headaches and require meticulous diagnosis because of their life-threatening potential. The secondary headaches include a diverse and fascinating array of etiologies which can mimic primary headache disorders ranging from the rare to the mundane and from the well established to the highly controversial. This issue of Neurologic Clinics is devoted entirely to secondary headaches with topics that include: Headaches due to nasal and paranasal sinus disease; Headaches due to vascular disorders; Headaches and brain tumors; Low cerebrospinal fluid pressure syndromes; Painful ophthalmologic disorders and eye pain; Idiopathic intracranial hypertension (pseudotumor cerebri); Cough, exertional, and sex headaches; The neck and headaches; Drug-induced headaches; Trigeminal neuralgia and glossopharyngeal neuralgia; Headaches and vasculitis; Tonsilar ectopia and headaches; Post-traumatic headaches; Metabolic headaches; Temporomandibular joint disorders, bruxism, and headaches.

Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS; Potential environmental factors in ALS; Neuropathology; Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS; Symptoms management and end of life care; Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data; Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?; Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.

Congential myopathies, Muscular dystropies, Glycogen storage diseases of muscle, and Idiopathic and Inflammatory myopathies are presented in this volume of Neurologic Clinics. Topics include: Muscle channelopathies; Pompe disease; Congenital myopathies and muscular dystrophies; Duchenne and Becker muscular dystrophies; Distal myopathies; Limb-girdle muscular dystrophy; Fascioscapulomuneral muscular dystrophy; Myotonic dystrophy; Metabolic and mitochondrial myopathies; Sporadic inclusion body myositis; Toxic myopathies; Idiopathic Inflammatory myopathies; Approach to muscle disease.

This issue of Neurologic Clinics, guest edited by Drs. Gary D. Clark and James J. Riviello, will cover key topics in Pediatric Neurology. This issue is one of four selected each year by our series consulting editor, Dr. Randolph W. Evans. Topics discussed in this issue will include: The State of Child Neurology; The Financial Power of Neurology in a Major Children's Hospital; Neurology in a Pandemic; Education: Training the Next Generation of Child Neurologists and Neurodevelopmental Disability Doctors, Student Education and Recruitment; Genetic Testing and Counseling in Child Neurology; Novel Treatments and Clinical Research in Child Neurology; Epilepsy: Novel Surgical Techniques and Monitoring; Epilepsy: Genetics; Epilepsy: Treatment of Epileptic Syndromes; Neuromodulation for Pediatric Epilepsy; Inflammatory Diseases of the Nervous System; Neurooncology; Neurocritical Care and Brain Monitoring; The Brain and Heart Disease in Children; Neurology of Sleep; and Evidence Based Protocols.

Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition updates the first biographical study of important contributors to the field of child neurology, consisting of over 250 biographical sketches written by over 100 physicians specializing in neurology, child neurology, pediatrics and obstetrics. Organized chronologically into six chapters, beginning before 1800 and continuing to the present, Child Neurology traces the emergence of child neurology as a separate specialty from its roots in pediatrics and neurology. With a definitive historical introduction by the editor, Dr. Stephen Ashwal. This new edition will feature a new section on The Dynamic Growth and Expansion of Child Neurology: The Late Twentieth Century (1960 to 2000+) and features about 138 new biographical sketches of leaders in the field during this recent time frame. Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition will be published on behalf of the Child Neurology Society, a professional society that strives to foster recognition and support for children with neurological disorders and to promote and exchange national and international scientific research, education, and training in the field of neurology. - Identifies top contributors to child neurology research from the 1800s to today - Includes 238 biographical sketches of contributors and their scientific research - Contains 138 new biographies on contributors from the late 20th and early 21st centuries - Authored by physicians and published by the Child Neurology Society

Genetic methodologies are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is evolving rapidly and expected to grow in scope as more disorders are linked to specific genetic markers. Part I covers basic genetic concepts and recurring biological themes, and begins the discussion of movement disorders and neurodevelopmental disorders, leading the way for Part II to cover a combination of neurological, neuromuscular, cerebrovascular, and psychiatric disorders. This volume in the Handbook of Clinical Neurology will provide a comprehensive introduction and reference on neurogenetics for the clinical practitioner and the research neurologist. - Presents a comprehensive coverage of neurogenetics - Details the latest science and impact on our understanding of neurological psychiatric disorders - Provides a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

This issue of Neurologic Clinics features a review of the latest therapeutic developments in common and less common neurologic disorders and includes the following articles: Latest Data on Platelet Antiaggregants in Stroke Prevention; New Anticoagulants for Atrial Fibrillation Stroke Prevention; Unanswered Questions in Thrombolytic Therapy for Acute Ischemic Stroke; New Strategies for Endovascular Recanalization of Acute Ischemic Stroke; New Developments in the Treatment of Intracerebral Hemorrhage. What is in the horizon?; New Therapies for Unruptured Intracranial Aneurysms; New and Emergency Therapies for Arteriovenous Malformations; Advances and Controversies in the Management of Cerebral Venous Thrombosis in Adults; Epilepsy: Neurostimulation and New Drug Targets; Surgical Treatment of Parkinson's Disease; Deep Brain Stimulation (DBS) in Non-Parkinsonian Movement Disorders and Emerging Technologies, Targets and Therapeutic Promises in DBS; Multiple Sclerosis. New and Emerging Therapies; Advances in the Medical Management of Myasthenia Gravis; Update in the Treatment of Primary Brain Tumors; and Immunotherapy for Alzheimer’s Disease.

Peripheral Neuropathy is a neurologic disorder characterized by damage to the peripheral nervous system, the part of the nervous system outside the central nervous system that connects it to all parts of the body. Over 100 forms of peripheral neuropathy have been identified. This issue of Neurologic Clinics features 12 articles about this disease that are of most interest to the clinician. Articles include: Diabetic Neuropathy; GBS and Variants; CIDP and Symmetrical Variants; Laboratory Evaluation of Peripheral Neuropathy; Treatment of Painful Peripheral Neuropathy;Cryptogenic Sensory Polyneuropathy; Vasculitic Neuropathy; Hereditary Neuropathy; Entrapment Neuropathy; Multifocal Motor Neuropathy and Multifocal Acquired Demyelinating Sensory and Motor Neuropathy; Nutritional Neuropathies.

Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice. Based on the authors' popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. - Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. - Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. - Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome. - Features a reader-friendly, full-color format, with plentiful diagrams, photographs, and tables. - Includes access to several hundred updated, professional-quality video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses.