Comparative Genomics and Proteomics in Drug Discovery gives an overview of how emerging genomic and proteomic technologies are making significant contributions to global drug discovery programs, and in particular the key role that comparative genomics and proteomics play within this strategy. Each chapter is written by respected authorities, with hands-on experience, from both academic and pharmaceutical backgrounds.

Designed as a comprehensive text for students and professionals pursuing careers in the fields of bioinformatics, molecular biology, pharmacy and drug research, the Fifth Edition continues to offer a fascinating and authoritative treatment of the entire spectrum of bioinformatics, covering a wide range of high-throughput technologies. The content can be used for four core courses: bioinformatics fundamentals, genomics, proteomics and drug discovery and design. The Fifth Edition takes a completely new pedagogical approach and the book is divided into eight distinct Units for the ease of learning: Bioinformatics Fundamentals, Sequence Alignment, Phylogenetic Analysis, Genomics, Protein Structure and Function, Drug Discovery Methods, Drug Design and Development and Integrative Topics. Accordingly, all the chapters are revised and updated in the new edition, besides introduction of seven new chapters and another seven completely re-written chapters. As a student-friendly text, it embodies several pedagogical features such as detailed examples, numerous tables, a large number of diagrams, flow charts and web resources. The book in its present edition should prove an invaluable asset to the students and researchers in the fields of bioinformatics, biotechnology, computer-aided drug design, information technology, medical diagnostics, molecular biology and pharmaceutical sciences. NEW TO THE FIFTH EDITION • Re-written chapters — Biological database search and data retrieval, Pair-wise alignment of sequences, PSSMs and Hidden Markov Models, Gene Mapping, Gene Prediction, Protein Structure Overview and Protein Structure Prediction. • Inclusion of new chapters—Scoring Matrices, Gene Sequencing, Regulatory Elements Prediction, Comparative Genomics, Protein Structure Databases, Protein Function Prediction and Potential Drug Targets. KEY FEATURES • Covers the field of bioinformatics in a complete and integrated approach – moving from the fundamentals to theory and practical applications. • State-of-the-art technologies for gene identification, molecular modeling and monitoring of cellular processes. • Data mining, data curation and analysis, classification, interpretation and efficient structure determination of genomes and proteomes. • Companion website provides useful resources for the teachers as well as for the students. So, visit Learning Centre https:// www.phindia.com/bioinformatics_mendiratta_rastogi to have access of Lecture notes, solutions manual, MCQs, problems set for practice, glossary of important terms, etc. TARGET AUDIENCE • UG and PG Students of Bioinformatics, Biotechnology, Molecular Biology and Pharmacy.

This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.

Gazing into crystal balls is beyond the expertise of most scientists. Yet, as we look further into the 21st century, one does not have to be Nostradamus to predict that the current genomics and proteomics "revolution" will have an immense impact on medical bacteriology. This impact is already being re- ized in many academic departments, and although encroachment on routine diagnostic bacteriology, particularly in the hospital setting, is likely to occur at a slower pace, it remains nonetheless inevitable. Therefore, it is important that no one working in bacteriology should find themselves distanced from these fundamental developments. The involvement of all clinical bacteriologists is essential if the significant achievements of genome sequencing and analysis are to be turned into tangible advances, with resulting benefits for patient care and m- agement. It is our hope that Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews will play a part in bringing such a development to fruition. The advances in genomics and proteomics have already given us frequent opportunities to reassess our knowledge and understanding of established b- terial adversaries, and have provided us with the means to identify new foes. The new knowledge gained is enabling us to reconsider, for example, our c- cepts of bacterial pathogenicity, phylogeny and novel targets for antibacterial chemotherapy. These topics, and others, are considered in Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews.

Designed as a text for students and professionals pursuing careers in the fields of molecular biology, pharmacy and bioinformatics, the fourth edition continues to offer a fascinating and authoritative treatment of the entire spectrum of bioinformatics, covering a wide range of high-throughput technologies. In this edition, four new chapters are included and two chapters are updated. As a student-friendly text, it embodies several pedagogic features such as detailed examples, chapter-end problems, numerous tables, a large number of diagrams, flow charts, a comprehensive glossary and an up-to-date bibliography. This book should prove an invaluable asset to students and researchers in the fields of bioinformatics, biotechnology, computer-aided drug design, information technology, medical diagnostics, molecular biology and pharmaceutical industry. NEW TO THE FOURTH EDITION: • Includes four new chapters—Introduction to Biological Databases, Introduction to Phylogenetic, Methods of Phylogenic analysis and RNA Predict. • Updates chapters on Information Search and Data Retrieval and Alignment of Multiple Sequences. • Incorporates Problem Sets containing more than 250 problems and Multiple Choice Questions so that students can test their knowledge and understanding. Key Features • State-of-the-art technologies for gene identification, molecular modeling and monitoring of cellular processes • Data mining, analysis, classification, interpretation and efficient structure determination of genomes and proteomes • Importance of cell cycle for discovering new drug targets and their ligands • Computer-aided drug design and ADME-Tox property prediction Companion website www.phindia.com/rastogi provides useful resources for the teachers as well as for the students.

"The Biotech Investor's Bible" ist der maßgebliche Leitfaden für die Geldanlage in die zunehmend beliebteren, aber außerordentlich schwankungsanfälligen Biotechnologiewerte. Dieses einzigartige Buch erklärt die Grundlagen von Genetik, Patenten und Therapien und zeigt dem Anleger, wie er Biotechnologieunternehmen, deren Spitzentechnologie und neuesten Produkte bewertet. "The Biotech Investor's Bible" bietet eine interessante Zusammenfassung der relativ kurzen Geschichte dieses Industriezweiges und vermittelt einen umfassenden Überblick über verschiedene Branchenbereiche. Technologie und Wissenschaft des Biotechnologiemarktes werden zusammen mit detaillierten Investmentstrategien ausführlich erläutert. Autor George Wolff ist ein erfahrener Experte auf diesem Gebiet. "The Biotech Investor's Bible" ist eine unverzichtbare Lektüre für aktuelle und künftige Biotech-Anleger.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

The volume covers recent research materials from countries like India, USA, Japan, European Union, UK etc. on vegetable Science, Fruit Science, Ornamentals, Spices, Plantation Crops and Postharvest Technology. Contributed by the best teachers and scientists in the field. The volumes expose the readers to the basics of Horticultural practices and phenomena with chapters on: 1. Geographical Indications in horticulture by Elsy, C.R. and Mridula N. 2. Emerging trends in bioinformatics by Keshavachandran, R., Reena, N. and Nancy Thomas. 3. Chemistry of Fragrance by Shamina Azeez. 4. Advances in development of salt and water stress tolerant plants by Vanaja T. 5. Physiology of dormancy by Passam, Harold C and Alexopoulos, Alexios A. 6. Principles of preservation and packing to improve quality and extend shelf life of fresh horticultural produce by Bakshi, A.K. and Aggarwal Poonam. 7. Graft incompatibility by Masayo Kawaguchi, David Backhouse, Acram Taji and Masayuki Oda. 8. Role and symptoms of deficiency of micronutrients in horticultural crops by Nirmala Devi, S. and Sadhan Kumar P.G. 9. History of bioinformatics by Keshavachandran R. and Nancy Thomas. 10. Entomology in India - a historical perspective by Sosamma Jacob. 11. Ecofriendly approaches for the management of pests and disease of horticultural crops by Nakkeeran S., Renuka Devi P and Marimuthu T. 12. HELO priming in vegetable crops by Krishna Kumar K. 13. Controlled atmosphere storage of fruits by Sudhakar Rao, D.V. Gopalakrishna Rao, K.P. and Narayana C.K. 14. Physiology of fruit ripening by Dhillon W.S. and Gill P.P.S. 15. Trade in floriculture by Sheela Jayagopan.

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

The nature of cancer disease, its probable causes, and the molecular and cellular mechanisms through which malignant tumours develop, have only recently begun to be understood in any appreciable detail. Cancer is fundamentally a disease of the genome, arising from dynamic changes occurring within DNA during the lifetime of the cell e.g. deletions, amplifications, point mutations, translocations, that can occur in any cell and that may interact in a variety of cellular pathways. The imbalance in the interplay between genetic and environmental factors can initiate malignancy. The determination of the human genome sequence is acclaimed as one of the great achievements made possible by the rapid progress in the available molecular biology tools achieved during the last few years. The sequence of the human genome promises to unveil invaluable information useful for the development of novel approaches in the diagnosis and treatment of cancer disease. This book includes part of the work of international experts on the most up-to-date developments of various aspects of research on genome and proteome in oncology. The scientists suggest that the genetic key to human complexity lies not in the number of genes but in how gene parts are used to build different products in a process of the mRNA transcript called alternative splicing.