This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well. Also available online via ScienceDirect (2006) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. Comprehensively reviews - the strategies, technologies, principles and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

This e-book comprises 8 volumes, with all chapter sections available as PDF or HTML, and includes bibliographical references and index.

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

In this introduction to each of the major sectors of the chemical industry the authors cover the important chemistry, products, processes and relevant statistics. Each contributor draws on his/her extensive industrial experience to give a balanced coverage which is both easy to read and authoritative. New chapters on quality and safety issues, environmental issues and an extended chapter on chlor-alkali, sulphur and nitrogen industries, reflect the importance of these subjects today.