Computational Biomedicine unifies the different strands of a broad-ranging subject to demonstrate the power of a tool that has the potential to revolutionise our understanding of the human body, and the therapeutic strategies available to maintain and protect it.

This volume explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. The first section collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. The second section delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step and readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Performance Computing for Drug Discovery and Biomedicine allows a diverse audience, including computer scientists, computational and medicinal chemists, biologists, clinicians, pharmacologists and drug designers, to navigate the complex landscape of what is currently possible and to understand the challenges and future directions of HPC-based technologies.

This book provides an accessible yet rigorous introduction to topology and homology focused on the simplicial space. It presents a compact pipeline from the foundations of topology to biomedical applications. It will be of interest to medical physicists, computer scientists, and engineers, as well as undergraduate and graduate students interested in this topic. Features: Presents a practical guide to algebraic topology as well as persistence homology Contains application examples in the field of biomedicine, including the analysis of histological images and point cloud data

This two-volume set LNCS 6691 and 6692 constitutes the refereed proceedings of the 11th International Work-Conference on Artificial Neural Networks, IWANN 2011, held in Torremolinos-Málaga, Spain, in June 2011. The 154 revised papers were carefully reviewed and selected from 202 submissions for presentation in two volumes. The first volume includes 69 papers organized in topical sections on mathematical and theoretical methods in computational intelligence; learning and adaptation; bio-inspired systems and neuro-engineering; hybrid intelligent systems; applications of computational intelligence; new applications of brain-computer interfaces; optimization algorithms in graphic processing units; computing languages with bio-inspired devices and multi-agent systems; computational intelligence in multimedia processing; and biologically plausible spiking neural processing.

This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues – often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems.

This proceedings volume details both current and future research and development initiatives in nano-biomedical engineering, arguably the most important technology of the world in the 21st century. It deals with the following four groups of nano-biomedical engineering: nano-biomechanics, nano-bioimaging, nano-biodevices, and nano-biointervention.Consisting of a compilation of studies conducted by group members of the Tohoku University Global Center of Excellence Program, with specially coordinated funding from the Japanese Government, the papers emphasize the integration of research and education collaboration between engineering and medicine, and showcase Japan's top-level research in the field of nano-biomedical engineering./a

This highly anticipated new edition provides a comprehensive account of face recognition research and technology, spanning the full range of topics needed for designing operational face recognition systems. After a thorough introductory chapter, each of the following chapters focus on a specific topic, reviewing background information, up-to-date techniques, and recent results, as well as offering challenges and future directions. Features: fully updated, revised and expanded, covering the entire spectrum of concepts, methods, and algorithms for automated face detection and recognition systems; provides comprehensive coverage of face detection, tracking, alignment, feature extraction, and recognition technologies, and issues in evaluation, systems, security, and applications; contains numerous step-by-step algorithms; describes a broad range of applications; presents contributions from an international selection of experts; integrates numerous supporting graphs, tables, charts, and performance data.

This title is part of a two-volume set that constitute the refereed proceedings of the 10th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2007. Coverage in this first volume includes diffusion tensor imaging and computing, cardiac imaging and robotics, image segmentation and classification, image guided intervention and robotics, innovative clinical and biological applications, brain atlas computing, and simulation of therapy.

This book aims to provide physicians and scientists with the basics of Artificial Intelligence (AI) with a special focus on medical imaging. The contents of the book provide an introduction to the main topics of artificial intelligence currently applied on medical image analysis. The book starts with a chapter explaining the basic terms used in artificial intelligence for novice readers and embarks on a series of chapters each one of which provides the basics on one AI-related topic. The second chapter presents the programming languages and available automated tools that enable the development of AI applications for medical imaging. The third chapter endeavours to analyse the main traditional machine learning techniques, explaining algorithms such as random forests, support vector machines as well as basic neural networks. The applications of those machines on the analysis of radiomics data is expanded in the fourth chapter to allow the understanding of algorithms used to build classifiers for the diagnosis of disease processes with the use of radiomics. Chapter five provides the basics of natural language processing which has revolutionized the analysis of complex radiological reports and chapter six affords a succinct introduction to convolutional neural networks which have revolutionized medical image analysis enabling automated image-based diagnosis, image enhancement (e.g. denoising), protocolling etc. The penultimate chapter provides an introduction to data preprocessing for use in the aforementioned artificial intelligence applications. The book concludes with a chapter demonstrating AI-based tools already in radiological practice while providing an insight about the foreseeable future. It will be a valuable resource for radiologists, computer scientists and postgraduate students working on medical image analysis.

A step-by-step guide to using computational tools to solve problems in cell biology Combining expert discussion with examples that can be reproduced by the reader, A Cell Biologist's Guide to Modeling and Bioinformatics introduces an array of informatics tools that are available for analyzing biological data and modeling cellular processes. You learn to fully leverage public databases and create your own computational models. All that you need is a working knowledge of algebra and cellular biology; the author provides all the other tools you need to understand the necessary statistical and mathematical methods. Coverage is divided into two main categories: Molecular sequence database chapters are dedicated to gaining an understanding of tools and strategies—including queries, alignment methods, and statistical significance measures—needed to improve searches for sequence similarity, protein families, and putative functional domains. Discussions of sequence alignments and biological database searching focus on publicly available resources used for background research and the characterization of novel gene products. Modeling chapters take you through all the steps involved in creating a computational model for such basic research areas as cell cycle, calcium dynamics, and glycolysis. Each chapter introduces a new simulation tooland is based on published research. The combination creates a rich context for ongoing skill and knowledge development in modeling biological research systems. Students and professional cell biologists can develop the basic skills needed to learn computational cell biology. This unique text, with its step-by-step instruction, enables you to test and develop your new bioinformatics and modeling skills. References are provided to help you take advantage of more advanced techniques, technologies, and training.