Updated to reflect the notable advances in cardiac computed tomography (CT) imaging, the Second Edition of the best-selling Computed Tomography of the Coronary Arteries provides cardiologists and radiologists with a practical text that explains the basic principles and applications of CT. Written by renowned international experts in the field, this

Most cardiologists and radiologists are not acquainted with CT coronary imaging. This has inspired the compilation of this book, which is the culmination of the collaborated effort of cardiologists and radiologists to draw up a practical CT book explaining the basic principles and applications of CT by use of many illustrations and tables and avoid

Computed tomography (CT) is an increasingly used modality for investigations of patients with suspected coronary artery disease (CAD). Technical advances could improve diagnostic accuracy and lead to clinical workflow improvements. Also, more prognostic information can optimize clinical follow-up strategies and treatments. The general aim of this thesis was to explore the use of CT for CAD investigations. Three studies aimed to examine new technologies, including the evaluation of an on-site, computed tomography-based fractional flow reserve (CT-FFR) software (study I), the evaluation of an AI-based, calcium scoring computed tomography (CSCT) software (study III), and the evaluation of an photon-counting detector (PCD)-CT (study IV). One study aimed to evaluate the long-term prognostic value of coronary computed tomography angiography (CCTA) in symptomatic patients with no history of CAD (study II). The software evaluation studies (study I and III) and the prognostic study (study II) utilized CT data from clinical patients, while the PCD-CT evaluation study (study IV) used CT data from cadaveric specimens. The performances of both software programs were compared with standard references, being represented by fractional flow reserve (FFR) measurements (study I), and coronary artery calcification (CAC) scores from a semi-automatic software (study III), respectively. The PCD-CT performance on CAC quantification was compared with corresponding results from an energy integrating detector (EID)-CT, using micro-CT as the standard reference (study IV). The prognostic study merged registries to identify major adverse cardiac events (MACE), having a follow-up time of up to 7.5 years (study II). The CT-FFR and CSCT software correlation and agreement to corresponding standard references were good and excellent, respectively. Also, both software programs had time-saving potential (study I and III). The CAC quantification was more accurate using PCD-CT than EID-CT (study IV). The prognosis was excellent in patients with normal coronary arteries, and progressively impaired in non-obstructive and obstructive CAD (study II). The results in this thesis convey developmental, technical CT technology advances for CAD investigations. In addition, prognostic follow-up data is communicated. The results may benefit patients by an increased accuracy in the CT evaluation of CAD and can contribute to improve clinical follow-up strategies. Furthermore, the results suggest possibilities to improve the workflow in clinical radiology, which potentially could impact health care costs. Datortomografi (DT) är en kliniskt använd modalitet för utredning av misstänkt kranskärlsjukdom. För att förbättra framtida diagnostik, klinisk effektivitet och uppföljningsstrategier är det av stor vikt med teknisk vidareutveckling, och att erhålla relevant prognostisk information. Syftet med denna avhandling var att studera användandet av DT vid misstänkt kranskärlssjukdom. Tre studier syftade till att utvärdera nya tekniker, vilket innefattade utvärderingar av två nya mjukvaror samt en utvärdering av fotonräknar-DT (FR-DT). En studie syftade till att utvärdera det prognostiska värdet av DT kranskärl. Det första delarbetet utvärderade en mjukvara, som använde data från DT kranskärl för att beräkna tryckfall över misstänkta kranskärlsstenoser. Tiden för att erhålla tryckfallsmätningarna registrerades också. Resultaten av tryckfallsmätningarna jämfördes med en standardreferens, vilken utgjordes av invasiva, kateterburna tryckfallsregistreringar. Det andra delarbetet undersökte prognosen för patienter med olika fynd vid DT kranskärl. Genom registersamkörning erhölls data om kranskärlsrelaterad sjukdom med uppföljningstid på upp till 7.5 år. Det tredje delarbetet utvärderade en AI-mjukvara som utförde automatiska mätningar av kranskärlskalk, baserat på kliniskt utförda DT-undersökningar för detta ändamål (calcium scoring). Tiden för att erhålla mätningarna registrerades också. Resultaten jämfördes med en standardreferens, vilken utgjordes av en konventionell, semi-automatisk metod. Det fjärde delarbetet utvärderade förmågan att kvantifiera kranskärlskalk från avlidna med FRDT. Bilder från både FR-DT och DT användes för kvantifiering av kalkvolym och jämfördes med en standardreferens, vilken utgjordes av micro-DT. Korrelationen och överenstämmelsen mellan mjukvarorna och standardreferenserna var god för tryckfallberäkningarna över kranskärlsförträngningar, och mycket god för AI-baserad mätning av kranskärlskalk. Båda mjukvarorna hade tidsbesparande potential. För patienter med normala kranskärl var prognosen utmärkt, men den försämrades med ökad grad av kranskärlssjukdom. Användande av FR-DT bidrog till en bättre noggrannhet än DT vid kvantifiering av kranskärlskalk. Avhandlingen förmedlar värdet av teknisk utveckling vid utredning med DT för misstänkt kranskärlssjukdom. Dessutom presenteras nya, prognostiska data. Resultaten kan gynna patienten genom skärpt diagnostik och mer effektiva utredningar, vilket kan ge framtida ekonomiska effekter. Därtill kan de prognostiska resultaten bidra till förbättrade, kliniska uppföljningsstrategier.

Recent years have seen a marked increase in cardiovascular computed tomography (CT) imaging, with the technique now integrated into many imaging guidelines, such as those published by ESC and NICE. Rapid clinical and technological progress has created a need for guidance on the practical aspects of CT image acquisition, analysis and interpretation. The Oxford Specialist Handbook of Cardiovascular CT, now revised for the second edition by practising international experts with many years of hands-on experience, is designed to fulfil this need. The Handbook is a practical guide on performing, analysing and interpreting cardiovascular CT scans, covering all aspects from patient safety to optimal image acquisition to differential diagnoses of tricky images. It takes an international approach to both accreditation and certification, highlighting British, European, and American examinations and courses. The format is designed to be accessible and is laid out in easy to navigate sections. It is meant as a quick-reference guide, to live near the CT scanner, workstation, or on the office shelf. The Handbook is aimed at all cardiovascular CT users (Cardiologists, Radiologists and Radiographers), particularly those new to cardiovascular CT, although even the advanced user should find useful tips and tricks within.

Coronary CT angiography has attained increasing scientific attention at academic institutions and has become a highly accurate diagnostic modality. Extending this knowledge into a practice setting is the purpose of "Coronary CT Angiography". This book will assist you in integrating cardiac CT into your daily practice, while also giving an overview of the current technical status and applications. The specific features of scanners from all four main vendors are also presented providing an objective overview of noninvasive coronary angiography using CT.

This new case-based book fills a gap in the literature by guiding the reader through the challenging clinical problems encountered in daily practice. Each case presents the clinician with a complete patient work-up that includes clinical history, radiological and clinical findings, treatment summary and suggested readings. Ideal for radiology and cardiology residents, as well as experienced physicians, this text helps the reader arrive at a diagnosis for each clinical problem presented.

In non-fatal cases, cardiovascular diseases are associated with a decreased quality of life as well as a substantial economic burden to society. Most sudden cardiac events are related to the complications of a non-stenosing marginal plaque. For this reason, the ability to properly identify the atherosclerotic plaque with rapid, non-invasive techniques is of utmost clinical interest in diagnostic workup and therapeutic planning of symptomatic patient. Nowadays CT produces high-quality images of the coronary arteries, in addition to defining their location and the extent of the atherosclerotic involvement. This new edition is enriched with two important additions. Firstly, dedicated chapters on intravascular ultrasound (IVUS), catheter angiography, and nuclear imaging have been included, with some discussions on theoretical techniques such as optical coherence tomography (OCT) and magnetic resonance imaging (MRI). Secondly, a completely new section comprising more than 70 clinical cases remarkably expands the horizons reached by the previous edition. This volume provides general practitioners and cardiologists with a basic understanding of the imaging techniques. For radiologists with no direct experience in cardiac imaging, the book serves as an important source of information on coronary pathophysiology and anatomy.

Written by the world’s foremost authorities, this volume provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. This edition has been thoroughly updated, sharply focused on clinical information, and trimmed to one manageable volume. Coverage begins with a review of risk factors and prevention, emphasizing lipid abnormalities, hypertension, smoking, diabetes, and obesity. Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. Clinical presentations, medical management, and the latest interventional strategies are included.

This is the first monograph to focus exclusively on coronary radiology. It is particularly timely, given that the emergence of computed tomography and magnetic resonance imaging, coupled with improvements in both hard- and software, has made reproducible non-invasive coronary imaging a practical reality. A wide range of topics is addressed, including: quantitative angiography, intravascular and quantitative ultrasound, multislice and electron beam computed tomography, magnetic resonance coronary angiography and use of the coronary calcium score as an independent risk factor. All of the latest developments, such as non-invasive intracoronary thrombus imaging, are covered. Particular care has been taken to consider the common questions confronted in asymptomatic patients. The text is supported by high-quality color images of the coronary and cardiac anatomy.

Cardiovascular and Coronary Artery Imaging, Volume One covers state-of-the-art approaches for automated non-invasive systems in early cardiovascular disease diagnosis. The book includes several prominent imaging modalities, such as MRI, CT and PET technologies. A special emphasis is placed on automated imaging analysis techniques, which are important to biomedical imaging analysis of the cardiovascular system. This is a comprehensive, multi-contributed reference work that details the latest developments in spatial, temporal and functional cardiac imaging. - Takes an integrated approach to cardiovascular and coronary imaging, covering machine learning, deep learning and reinforcement learning approaches - Covers state-of-the-art approaches for automated non-invasive systems for early cardiovascular disease diagnosis - Provides a perspective on future cardiovascular imaging and highlights areas that still need improvement